DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4b1 and Cyp4ae1

DIOPT Version :9

Sequence 1:	NP_058695.2	Gene:	Cyp4b1 / 24307	RGDID:	2480	Length:	511	Species:	Rattus norvegicus
Sequence 2:	NP_525044.1	Gene:	Cyp4ae1 / 31193	FlyBaseID:	FBgn0015036	Length:	496	Species:	Drosophila melanogaster

Alignment Length:	514	Identity:	165/514 - (32%)
Similarity:	267/514 - (51%)	Gaps:	50/514 - (9%)

- Green bases have known domain annotations that are detailed below.

  Rat    19 VVILMV------IVLKLFSLLLR--RQKLARAMDSFPGPPTHWLFGHALEIQKL---GSLDKVVS 72
            :|:|:|      :|..||.|.|:  |..|...:.|....|   |.|.|.:::..   ...||...
  Fly     2 LVVLLVALLVTRLVASLFRLALKELRHPLQGVVPSVSRVP---LLGAAWQMRSFQPDNLHDKFAE 63

  Rat    73 WAQQFPHAHPLWFGQFVGFLNIY--EPDYAKA-VYSRGDPKAADVYDFFLQWIGKGLLVLDGPKW 134
            :.::|..:   :.|..:|.:.:.  ||.:..| :..:...|...:|.....|:|.|||:..|.:|
  Fly    64 YVKRFGRS---FMGTVLGHVVMVTAEPRHIDALLQGQHQLKKGTMYFALRGWLGDGLLLSRGKEW 125

  Rat   135 FQHRKLLTPGFHYDVLKPYVAIFAESTRMMLDKWEKKASENKSFDIFCDVGHMALDTLMKCTFGK 199
            ...||::||.||:.:|:.:|.:|...:.:::::....:..|:..:|:..||..|||.:.:...|.
  Fly   126 HTMRKIITPTFHFSILEQFVEVFDRQSSILVERLRTLSYGNEVVNIYPLVGLAALDIITETAMGV 190

  Rat   200 GDSGLGHRDNSYYLAVSDLTLLMQQRIDSFQYHNDF-----IYWLTPHGRRFLRACKIA-HDHTD 258
            .....| .|:....||.|||.::..|.  .:.|..|     :.|  |.|.|..:|..|. |:.|:
  Fly   191 NVDAQG-ADSEVVHAVKDLTNILATRF--MRPHLLFPHLFRLCW--PSGFRKQQAGVICLHEFTN 250

  Rat   259 EVIRQRKAALQDEKERKKIQQRRHLDFLDILLGVRDESGIKLSDAELRAEVDTFMFEGHDTTTSG 323
            .:|.||:..|..|..:.|..:...|  ||.||....: |..|:|.::|.||:||:|||||||||.
  Fly   251 GIIEQRRRLLAREANQDKPTKPHAL--LDTLLRATVD-GQPLTDKQIRDEVNTFIFEGHDTTTSA 312

  Rat   324 ISWFLYCMALYPEHQQLCREEVRGILGDQDSFQ---WDDLAKMTYLTMCMKECFRLYPPVPQVYR 385
            :|:.||.::.:...||...||:|...| ||.|:   ..|.|.:.||:..:||..|||||:|.|.|
  Fly   313 VSFCLYLLSRHEAVQQKLFEELRMHYG-QDLFRGVILSDFATLPYLSCVVKESLRLYPPIPAVAR 376

  Rat   386 QLNKPVTFVDGRSLPAGSLISLHIYALHRNSTVWPDPEVFDPLRFSPENAAGRHPFAFMPFSAGP 450
            .|.|.:. :|...:|.|:.:.:.::.|.|:..::.||.||.|.|...|.|....|::::||||||
  Fly   377 CLEKDLV-IDEGYIPVGTNVVVLLWQLLRDEAIFTDPLVFQPERHLGEEAPRLSPYSYIPFSAGP 440

  Rat   451 RNCIGQQFAMNEMKVVTALCLLRFEF-----SLDPSKMPIKVPQLILRSKNGIHLYLKP 504
            ||||||:||:.|||.:....:..::.     .::||   ||:   :||||:|:::.|:|
  Fly   441 RNCIGQKFALLEMKTMVTKVIRHYQLLPMGADVEPS---IKI---VLRSKSGVNVGLRP 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4b1	NP_058695.2	p450	47..500	CDD:278495	152/472 (32%)
Cyp4ae1	NP_525044.1	p450	35..486	CDD:278495	152/472 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348659
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.740