DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4a2 and Cyp4p3

DIOPT Version :9

Sequence 1:	XP_038965182.1	Gene:	Cyp4a2 / 24306	RGDID:	2479	Length:	517	Species:	Rattus norvegicus
Sequence 2:	NP_610473.1	Gene:	Cyp4p3 / 35948	FlyBaseID:	FBgn0033397	Length:	515	Species:	Drosophila melanogaster

Alignment Length:	542	Identity:	152/542 - (28%)
Similarity:	262/542 - (48%)	Gaps:	86/542 - (15%)

- Green bases have known domain annotations that are detailed below.

  Rat    23 FLLSLFLVLFKAVQFYLRRQW-----------------------LLKALEKFPSTPSHWLWGHNL 64
            :|:..|:||.:.: :.|.|.:                       |:|....|.:  |..|:|
  Fly     5 WLVGAFIVLIQWI-YRLNRDYCILGFFAKRIRTKNGQNPESIAPLVKGSTIFAN--SFDLYG--- 63

  Rat    65 KDRE--FQQVLTWVEKFPGACLQWLSGSTARVLLYDPDYVKVVLGRSDPK------PYQSLAPWI 121
            ||..  |:......:|...:..::..| ||...:.|.|..:.||  :||.      .|..|.|::
  Fly    64 KDHSGVFEHSRDCAKKLGKSYAEYAMG-TAIYNVIDADSAERVL--NDPNLINKGTIYDFLHPFL 125

  Rat   122 GYGLLLLNGKKWFQHRRMLTPAFHYDILKPYVKIMADSVSIMLDKWEKLDDQDHPLEIFHYVSLM 186
            ..|||...||||...|:||:|.||::||..:.:|........|::::..|:.  .:.:...:...
  Fly   126 RTGLLTSTGKKWHARRKMLSPTFHFNILNQFQEIFITESLKFLEQFKGNDEA--IISLNEVIPRF 188

  Rat   187 TLDTVMKCAFSHQGSVQLDVNSRS---YTKAVEDLNNLIFFRVRSAFYGNSIIYNMSSDGRLSRR 248
            ||:::.:.|.    .|:||..:..   |.:....:......|:.:....:..::.|.::...: .
  Fly   189 TLNSICETAM----GVKLDEMAEKGDRYRENFRQIEECFIRRMSNPLLWSDTLFKMFAEKDYA-S 248

  Rat   249 ACQIAHEHTGSVFLLPAFLSLSDGVIKTRKAQLQN-----------EEELQKARKKRHLDFLDIL 302
            |..:.|             ..|..:|..|:.||.:           |:||..::|:  ...||.|
  Fly   249 ALDVVH-------------GFSSEIIAKRRDQLNDEIDSRGNTQTAEDELFTSKKR--FAMLDTL 298

  Rat   303 LFAKMEDGKSLSDE-DLRAEVDTFMFEGHDTTASGISWVFYALATHPEHQERCREEVQSILGDGT 366
            :.|: :||  |.|. .:..||||.||||:|||:.|:.:....::.:||.||:|.:|:|:.:.|..
  Fly   299 ILAE-KDG--LIDHIGICEEVDTLMFEGYDTTSIGLMFGLMNMSLYPEEQEKCYQEIQANIDDEL 360

  Rat   367 SV-TWDHLDQMPYTTMCIKEALRLYSPVPSVSRELSSPVTFPDGRSIPKGIRVTILIYGLHHNPS 430
            :: ....|:::......|||.:||:..||::.||.:......:|..:|||.::.:.::.:|.||.
  Fly   361 NILNIGQLNKLKNLEYFIKETMRLFPSVPAMGRETTRETELSNGLILPKGSQIFVHVFDIHRNPE 425

  Rat   431 YWPNPKVFDPSRFSPDSP--RHSHAYLPFSGGARNCIGKQFAMNELKVAVALTLLRFELLP--DP 491
            ||.:|:.|.|.||.|::.  ||::||:|||.|.|||||::|||.|:|..:...|.:|::||  ||
  Fly   426 YWDSPEEFRPERFLPENSQNRHTYAYIPFSAGQRNCIGQKFAMQEMKTLMVALLKQFQILPEIDP 490

  Rat   492 TRIPVPMPRLVLKSKNGIHLRL 513
            ..| |....|.|::||.||::|
  Fly   491 KTI-VFQTGLTLRTKNQIHVKL 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4a2	XP_038965182.1	CYP4B-like	69..512	CDD:410771	137/468 (29%)
Cyp4p3	NP_610473.1	p450	54..505	CDD:278495	139/484 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348504
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.850