DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4a2 and Cyp4ac3

DIOPT Version :9

Sequence 1:	XP_038965182.1	Gene:	Cyp4a2 / 24306	RGDID:	2479	Length:	517	Species:	Rattus norvegicus
Sequence 2:	NP_608918.1	Gene:	Cyp4ac3 / 33756	FlyBaseID:	FBgn0031695	Length:	509	Species:	Drosophila melanogaster

Alignment Length:	473	Identity:	136/473 - (28%)
Similarity:	230/473 - (48%)	Gaps:	78/473 - (16%)

- Green bases have known domain annotations that are detailed below.

  Rat    80 PGACLQWLSGSTARV--------LLYDPDYVKVVLGRSDPKPYQS------------LAPWIGYG 124
            |.....::..|||:.        .|:.|:| .:|......:.:||            :.|::|.|
  Fly    67 PANIFSYIRESTAKANGQNYIWNFLFAPEY-NIVRAEDAEEIFQSTKITTKNMSYELIRPFLGDG 130

  Rat   125 LLLLNGKKWFQHRRMLTPAFHYDILKPYVKIMADSVSIMLDKWEKLDDQD--HPLEIFHYVSLMT 187
            ||:...:||...|:.||||||::||:.::.|..:...    |:.|:.|::  ..||:...:...|
  Fly   131 LLISIDQKWHTRRKTLTPAFHFNILQSFLSIFKEESK----KFIKILDKNVGFELELNQIIPQFT 191

  Rat   188 LDTVMKCAFSHQGSVQLDVNS--RSYTKAVEDL---------NNLIFFRVRSAFYGNSIIYNMSS 241
            |:.:.:.|.    .|:||..|  ..|.||:.|.         |.|:||......:|:...|:
  Fly   192 LNNICETAL----GVKLDDMSEGNEYRKAIHDFEIVFNQRMCNPLMFFNWYFFLFGDYKKYS--- 249

  Rat   242 DGRLSRRACQIAHEHTGSVFLLPAFLSLSDGVIKTRKAQLQNEE--ELQKARKKRHLDFLDILLF 304
                  |..:..|             ..|.|:|:.::.|.:.::  ::.:..||:....||.||.
  Fly   250 ------RILRTIH-------------GFSSGIIQRKRQQFKQKQLGQVDEFGKKQRYAMLDTLLA 295

  Rat   305 AKMEDGKSLSDEDLRAEVDTFMFEGHDTTASGISWVFYALATHPEHQERCREEVQSILGDGTSVT 369
            |:.| || :..:.:..||:||||.|:|||::.:.:....||.|.:.||||.||:|.:..|...|:
  Fly   296 AEAE-GK-IDHQGICDEVNTFMFGGYDTTSTSLIFTLLLLALHADVQERCYEELQDLPEDIDEVS 358

  Rat   370 WDHLDQMPYTTMCIKEALRLYSPVPSVSRELSSPVTFPDGRSIPKGIRVTILIYGLHHNPSYWPN 434
            ....:::.:....|||:|||:...|.:.|..... :..:|..:||..:::|.||.:..:..::|.
  Fly   359 MFQFNELIHLECVIKESLRLFPSAPIIGRTCIEE-SVMNGLVLPKNAQISIHIYDIMRDARHFPK 422

  Rat   435 PKVFDPSRFSPDSP--RHSHAYLPFSGGARNCIGKQFAMNELKVAVALTLLRFELLPDPTRIPVP 497
            |..|.|.||.|::.  ||..|::|||.|.|||||::|.:.|:||.:|..:..|:||| .|::.
  Fly   423 PNQFLPERFLPENSVNRHPFAFVPFSAGPRNCIGQKFGVLEIKVLLAAVIRNFKLLP-ATQLE-- 484

  Rat   498 MPRLVLKSKNGIHLRLKK 515
                .|..:|||.||.::
  Fly   485 ----DLTFENGIVLRTQQ 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4a2	XP_038965182.1	CYP4B-like	69..512	CDD:410771	134/468 (29%)
Cyp4ac3	NP_608918.1	p450	51..504	CDD:278495	136/473 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348503
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.850