DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4a2 and Cyp4ac2

DIOPT Version :9

Sequence 1:	XP_038965182.1	Gene:	Cyp4a2 / 24306	RGDID:	2479	Length:	517	Species:	Rattus norvegicus
Sequence 2:	NP_608917.3	Gene:	Cyp4ac2 / 33755	FlyBaseID:	FBgn0031694	Length:	511	Species:	Drosophila melanogaster

Alignment Length:	546	Identity:	147/546 - (26%)
Similarity:	254/546 - (46%)	Gaps:	96/546 - (17%)

- Green bases have known domain annotations that are detailed below.

  Rat    18 FFQGAFLLSLFLVLFKAVQFYLRRQWLLKAL-------------EKFPSTPSHWLWGHNLKDREF 69
            |.:..|...|.:.:|:.:..:|.|.:.:.:|             .|....||...:|:|.....|
  Fly     2 FLEVLFAAPLVIFIFRKLWAHLNRTYFILSLCKRIRTEDGSLLESKIYVAPSKTRFGNNFDLVNF 66

  Rat    70 --QQVLTWVE----KFPGACLQWLSGSTARVLLYDPDYVKVVLGRS----DPKPYQSLAPWIGYG 124
              :.:..::.    |..|....|.........:...:..:.:|..|    ....|:.|.|::|.|
  Fly    67 TSESIFNFMRDASAKAKGRNYLWYFFHAPMYNIVRAEEAEEILQSSKLITKNMIYELLKPFLGEG 131

  Rat   125 LLLLNGKKWFQHRRMLTPAFHYDILKPY-----------VKIMADSVSIMLDKWEKLDDQDHPLE 178
            ||:...:||...|:.||||||:.:|:.:           ||::..||::             .||
  Fly   132 LLISTDQKWHSRRKALTPAFHFKVLQSFLIIFKEECNKLVKVLHQSVNM-------------ELE 183

  Rat   179 IFHYVSLMTLDTVMKCAFSHQGSVQLDVNSRS--YTKAVEDLNNLIFFRVRSAFYGNSIIYNMSS 241
            :...:...||:.|.:.|.    .|:||..|..  |.:::..:..::..|:.:.|:.|.:.:.:..
  Fly   184 LNQVIPQFTLNNVCETAL----GVKLDDLSEGIRYRQSIHAIEEVMQQRLCNPFFYNIVYFFLFG 244

  Rat   242 DGRLSRRACQIAHEHTGSVFLLPAFLSLSDGVIKTRKA-----QLQNEEELQKARKKRHLDFLDI 301
            |.|......:||||             .|..:|:.|::     ||..|:|.   .||:....||.
  Fly   245 DYRKQVNNLKIAHE-------------FSSNIIEKRRSLFKSNQLGQEDEF---GKKQRYAMLDT 293

  Rat   302 LLFAKMEDGKSLSDEDLRAEVDTFMFEGHDTTASGISWVFYALATHPEHQERCREEVQSILGDGT 366
            ||.|: .||: :..:.:..||:||||||:|||::.:.:....||.|.:.|::|.||::.:..|..
  Fly   294 LLAAE-ADGQ-IDHQGICDEVNTFMFEGYDTTSTCLIFTLLMLALHEDVQKKCYEEIKYLPDDSD 356

  Rat   367 SVTWDHLDQMPYTTMCIKEALRLYSPVPSVSRE-LSSPVTFPDGRSIPKGIRVTILIYGLHHNPS 430
            .::....:::.|....|||:|||:..||.:.|. :...|.  :|..:||..::.|.:|.:..:..
  Fly   357 DISVFQFNELVYMECVIKESLRLFPSVPFIGRRCVEEGVV--NGLIMPKNTQINIHLYEIMRDAR 419

  Rat   431 YWPNPKVFDPSRFSPDSP--RHSHAYLPFSGGARNCIGKQFAMNELKVAVALTLLRFELLP---- 489
            ::.|||:|.|.||.|::.  ||..|::|||.|.|||||::||:.|:||.:|..:..|::||
  Fly   420 HFSNPKMFQPDRFFPENTVNRHPFAFVPFSAGQRNCIGQKFAILEIKVLLAAVIRNFKILPVTLL 484

  Rat   490 DPTRIPVPMPRLVLKSKNGIHLRLKK 515
            |.           |..:|||.||.|:
  Fly   485 DD-----------LTFENGIVLRTKQ 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4a2	XP_038965182.1	CYP4B-like	69..512	CDD:410771	132/477 (28%)
Cyp4ac2	NP_608917.3	p450	57..505	CDD:278495	137/491 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348502
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.850