DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4a2 and Cyp4d2

DIOPT Version :9

Sequence 1:	XP_038965182.1	Gene:	Cyp4a2 / 24306	RGDID:	2479	Length:	517	Species:	Rattus norvegicus
Sequence 2:	NP_001284806.1	Gene:	Cyp4d2 / 31192	FlyBaseID:	FBgn0011576	Length:	501	Species:	Drosophila melanogaster

Alignment Length:	469	Identity:	163/469 - (34%)
Similarity:	257/469 - (54%)	Gaps:	46/469 - (9%)

- Green bases have known domain annotations that are detailed below.

  Rat    70 QQVLTWVE----KFPGACLQWLSGSTARVLLYDPDYVKVVLGR----SDPKPYQSLAPWIGYGLL 126
            :|::.:|:    |:......|:....| |...||..::.||..    :....|:.|..|:|.|||
  Fly    52 EQIMDFVKKNQRKYGRLYRVWILHQLA-VFSTDPRDIEFVLSSQQHITKNNLYKLLNCWLGDGLL 115

  Rat   127 LLNGKKWFQHRRMLTPAFHYDILKPYVKIMADSVSIMLDKWEKLDDQDHPLEIFHYVSLMTLDTV 191
            :..|:||...|:::||.||:.||:.:|:|.....::|:::.:...|...|:.||..:.|..||.:
  Fly   116 MSTGRKWHGRRKIITPTFHFKILEQFVEIFDQQSAVMVEQLQSRADGMTPINIFPVICLTALDII 180

  Rat   192 MKCAFSHQGSVQLDVNSRSYTKAVEDLNNLIFFRVRSAFYGNSIIYNMS--SDGRLSRRACQIAH 254
            .:.|...:.:.|.:.| ..|.:||.|:.|::..|...|:.....|:.::  ::.:...:|.::.|
  Fly   181 AETAMGTKINAQKNPN-LPYVQAVNDVTNILIKRFIHAWQRVDWIFRLTQPTEAKRQDKAIKVMH 244

  Rat   255 EHTGSVFLLPAFLSLSDGVIKTRKAQLQN-------EEELQKARKKRHLDFLDILLFAKMEDGKS 312
            :.|             :.:|:.|:..|.|       |||:....:||.:..||:||.:.: ||..
  Fly   245 DFT-------------ENIIRERRETLVNNSKETTPEEEVNFLGQKRRMALLDVLLQSTI-DGAP 295

  Rat   313 LSDEDLRAEVDTFMFEGHDTTASGISWVFYALATHPEHQERCREEVQSILGDG--TSVTWDHLDQ 375
            |||||:|.|||||||||||||.|.||:..|.::.|||.|:|.::|::.:||:.  :.||...|.:
  Fly   296 LSDEDIREEVDTFMFEGHDTTTSAISFCLYEISRHPEVQQRLQQEIRDVLGEDRKSPVTLRDLGE 360

  Rat   376 MPYTTMCIKEALRLYSPVPSVSRELSSPVTFPDGRSIPKGIRVTILIYGLHHNPSYWPNPKVFDP 440
            :.:....|||:|||:.|||.:.|..:..|.. .|:.||.|...|:.|:.|..:|.|:.:|..|.|
  Fly   361 LKFMENVIKESLRLHPPVPMIGRWFAEDVEI-RGKHIPAGTNFTMGIFVLLRDPEYFESPDEFRP 424

  Rat   441 SRFSPDSPR-HSHAYLPFSGGARNCIGKQFAMNELKVAVALTLLRFELLPDPTRIPVPMPR---- 500
            .||..|.|: |.:||:|||.|.|||||::|||.|:|..|:..|..|||||     ..|.||
  Fly   425 ERFDADVPQIHPYAYIPFSAGPRNCIGQKFAMLEMKSTVSKLLRHFELLP-----LGPEPRHSMN 484

  Rat   501 LVLKSKNGIHLRLK 514
            :||:|.||:||.||
  Fly   485 IVLRSANGVHLGLK 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4a2	XP_038965182.1	CYP4B-like	69..512	CDD:410771	160/465 (34%)
Cyp4d2	NP_001284806.1	p450	32..495	CDD:278495	159/464 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348472
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.650