DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4a2 and Cyp4d1

DIOPT Version :9

Sequence 1:	XP_038965182.1	Gene:	Cyp4a2 / 24306	RGDID:	2479	Length:	517	Species:	Rattus norvegicus
Sequence 2:	NP_476907.2	Gene:	Cyp4d1 / 31188	FlyBaseID:	FBgn0005670	Length:	512	Species:	Drosophila melanogaster

Alignment Length:	530	Identity:	167/530 - (31%)
Similarity:	284/530 - (53%)	Gaps:	61/530 - (11%)

- Green bases have known domain annotations that are detailed below.

  Rat    21 GAFLLS-LFLVLFKAVQFYLRRQWLLKALEKFPSTP-------SHWLWG---HNLKDREFQQVLT 74
            ||.|.| ||:.|   :.::|:.:.|:..:...|..|       .|...|   |.:..:.|:.:.|
  Fly     6 GAILASALFVGL---LLYHLKFKRLIDLISYMPGPPVLPLVGHGHHFIGKPPHEMVKKIFEFMET 67

  Rat    75 W----VEKFPGACLQWLSGSTARVLLYDPDYVKVVLG--RSDPK--PYQSLAPWIGYGLLLLNGK 131
            :    |.|.      || |....||:.:|..|:||||  |.:.|  .|::|.||:..|||:..|:
  Fly    68 YSKDQVLKV------WL-GPELNVLMGNPKDVEVVLGTLRFNDKAGEYKALEPWLKEGLLVSRGR 125

  Rat   132 KWFQHRRMLTPAFHYDILKPYVKIMADSVSIMLDKWE--KLDDQDHPLEIFHYVSLMTLDTVMKC 194
            ||.:.|:::|||||:.||..:|::.......:|...|  :|...|....::.:::|.|:||:.:.
  Fly   126 KWHKRRKIITPAFHFKILDQFVEVFEKGSRDLLRNMEQDRLKHGDSGFSLYDWINLCTMDTICET 190

  Rat   195 AFSHQGSVQLDVNSRSYTKAVEDLNNLIFFRVRSAFYGNSIIYNMSSDGRLSRRACQIAHEHTGS 259
            |.....:.|.:.:| .|.:||:.::.::..|:.:..|...:.|.::...|..::|..:.|:.|
  Fly   191 AMGVSINAQSNADS-EYVQAVKTISMVLHKRMFNILYRFDLTYMLTPLARAEKKALNVLHQFT-- 252

  Rat   260 VFLLPAFLSLSDGVIKTRKAQLQNEEELQKARK-------KRHLDFLDILLFAKMEDGKSLSDED 317
                       :.:|..|:.:|..|...|::..       ||.:.||||||.:.: |.:.||:.|
  Fly   253 -----------EKIIVQRREELIREGSSQESSNDDADVGAKRKMAFLDILLQSTV-DERPLSNLD 305

  Rat   318 LRAEVDTFMFEGHDTTASGISWVFYALATHPEHQERCREEVQSILGD--GTSVTWDHLDQMPYTT 380
            :|.|||||||||||||:|.:.:.||.:|||||.|::|.||::|::|:  .|.|:::.|:|:.|..
  Fly   306 IREEVDTFMFEGHDTTSSALMFFFYNIATHPEAQKKCFEEIRSVVGNDKSTPVSYELLNQLHYVD 370

  Rat   381 MCIKEALRLYSPVPSVSRELSSPVTFPDGRSIPKGIRVTILIYGLHHNPSYWPNPKVFDPSRF-- 443
            :|:||.||:|..||.:.|::...... :|:.||.|..:.|....|......:..|.:|.|.||
  Fly   371 LCVKETLRMYPSVPLLGRKVLEDCEI-NGKLIPAGTNIGISPLYLGRREELFSEPNIFKPERFDV 434

  Rat   444 -SPDSPRHSHAYLPFSGGARNCIGKQFAMNELKVAVALTLLRFEL--LPDPTRIPVPMPRLVLKS 505
             :.....:.:||:|||.|.|||||::|||.|:|..||..|..:|:  :.|.:..||.:..|:|::
  Fly   435 VTTAEKLNPYAYIPFSAGPRNCIGQKFAMLEIKAIVANVLRHYEVDFVGDSSEPPVLIAELILRT 499

  Rat   506 KNGIHLRLKK 515
            |..:..::::
  Fly   500 KEPLMFKVRE 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4a2	XP_038965182.1	CYP4B-like	69..512	CDD:410771	153/466 (33%)
Cyp4d1	NP_476907.2	p450	35..507	CDD:278495	158/494 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348474
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.750