DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4a2 and Cyp4g1

DIOPT Version :9

Sequence 1:	XP_038965182.1	Gene:	Cyp4a2 / 24306	RGDID:	2479	Length:	517	Species:	Rattus norvegicus
Sequence 2:	NP_525031.1	Gene:	Cyp4g1 / 30986	FlyBaseID:	FBgn0010019	Length:	556	Species:	Drosophila melanogaster

Alignment Length:	550	Identity:	160/550 - (29%)
Similarity:	252/550 - (45%)	Gaps:	98/550 - (17%)

- Green bases have known domain annotations that are detailed below.

  Rat    29 LVLFKAVQFYLRRQWLLKALEKFPSTPSHWLWGH-----NLKDREFQQV-LTWVEKFPGACLQWL 87
            ||.....:::.|.....:.:...||.|...:.|.     .|.:.|...| |.::.|:......||
  Fly    35 LVAMALYEYWRRNSREYRMVANIPSPPELPILGQAHVAAGLSNAEILAVGLGYLNKYGETMKAWL 99

  Rat    88 SGSTARVLLYDPDYVKVVLG----RSDPKPYQSLAPWIGYGLLLLNGKKWFQHRRMLTPAFHYDI 148
             |:...|.|.:|..::::|.    .:..:.|:...||.|.|||:.||..|..||:|:.|.||..|
  Fly   100 -GNVLLVFLTNPSDIELILSGHQHLTKAEEYRYFKPWFGDGLLISNGHHWRHHRKMIAPTFHQSI 163

  Rat   149 LKPYVKIMAD-SVSIM----LDKWEKLDDQDHPLEIFHYVSLMTLDTVMKCAFSHQGSVQLDVNS 208
            ||.:|....| |.:::    |:..:..|..|       |:|..|:|.::..|   .|..:|...:
  Fly   164 LKSFVPTFVDHSKAVVARMGLEAGKSFDVHD-------YMSQTTVDILLSTA---MGVKKLPEGN 218

  Rat   209 RS--YTKAVEDLNNLIFFRVRSAFYGNSIIYNMSSDGRLSRRACQIAHEHTGSVFLLPAFLSLSD 271
            :|  |.:||.|:.::|..|.....|....||..:.......|...|             .|.::.
  Fly   219 KSFEYAQAVVDMCDIIHKRQVKLLYRLDSIYKFTKLREKGDRMMNI-------------ILGMTS 270

  Rat   272 GVIKTRKAQLQNE-----EELQ------KARKKRHL-DFLD-------------ILLFAKMEDGK 311
            .|:|.||...|.|     ||:.      .|.||..| |.||             .||.|.:|..|
  Fly   271 KVVKDRKENFQEESRAIVEEISTPVASTPASKKEGLRDDLDDIDENDVGAKRRLALLDAMVEMAK 335

  Rat   312 S----LSDEDLRAEVDTFMFEGHDTTASGISWVFYALATHPEHQERCREEVQSILGDG--TSVTW 370
            :    .:::|:..||:|.||||||||::|.|:....:..|.:.|.:...|.::|.||.  ...|:
  Fly   336 NPDIEWNEKDIMDEVNTIMFEGHDTTSAGSSFALCMMGIHKDIQAKVFAEQKAIFGDNMLRDCTF 400

  Rat   371 DHLDQMPYTTMCIKEALRLYSPVPSVSRELSSPVTFPDG-RSIPKGIRVTILIYGLHHNPSYWPN 434
            ....:|.|....|.|.||||.|||.::|.|...:....| .::|||..|.:|.|.:|..|..:||
  Fly   401 ADTMEMKYLERVILETLRLYPPVPLIARRLDYDLKLASGPYTVPKGTTVIVLQYCVHRRPDIYPN 465

  Rat   435 PKVFDPSRFSPD--SPRHSHAYLPFSGGARNCIGKQFAMNELKVAVALTLLR------------F 485
            |..|||..|.|:  :.||.::::|||.|.|:|:|:::||.:|||.:: |::|            |
  Fly   466 PTKFDPDNFLPERMANRHYYSFIPFSAGPRSCVGRKYAMLKLKVLLS-TIVRNYIVHSTDTEADF 529

  Rat   486 ELLPDPTRIPVPMPRLVLKSKNGIHLRLKK 515
            :|..|          ::||.:||.::.|:|
  Fly   530 KLQAD----------IILKLENGFNVSLEK 549

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4a2	XP_038965182.1	CYP4B-like	69..512	CDD:410771	149/500 (30%)
Cyp4g1	NP_525031.1	p450	58..518	CDD:278495	148/484 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920