DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp1a1 and Cyp303a1

DIOPT Version :9

Sequence 1:	NP_036672.3	Gene:	Cyp1a1 / 24296	RGDID:	2458	Length:	524	Species:	Rattus norvegicus
Sequence 2:	NP_001285977.1	Gene:	Cyp303a1 / 49165	FlyBaseID:	FBgn0001992	Length:	503	Species:	Drosophila melanogaster

Alignment Length:	512	Identity:	142/512 - (27%)
Similarity:	219/512 - (42%)	Gaps:	91/512 - (17%)

- Green bases have known domain annotations that are detailed below.

  Rat    37 VPKGLKSPPGPWGLPFIGHVLTLGK--------------------NPHLSLTKLSQQYGDVLQIR 81
            |.|..:.||||...|.:|..|.:.:                    ||:       ..||    ::
  Fly    21 VRKPKRFPPGPAWYPIVGSALQVSQLRCRLGMFCKVIDVFARQYVNPY-------GFYG----LK 74

  Rat    82 IGSTPVVVLSGLNTIKQALVKQGDDFKGRPDLYSFTLIANGQSMTFNP------DSGPLWAARRR 140
            ||...||:....:.|.:.:.  .:|..||||...:.|      .|||.      ..|.:|..:||
  Fly    75 IGKDKVVIAYTNDAISEMMT--NEDIDGRPDGIFYRL------RTFNSRLGVLLTDGEMWVEQRR 131

  Rat   141 LAQNALKSFSIASDPTL-----ASSCYLEEHVSKEAEYLISKFQKLMAEVGHFDPFKYLVVSVAN 200
            .....||:|..|....:     .::|.|::        |..|..|...:....:......|.|.|
  Fly   132 FILRHLKNFGFARSGMMDIVHNEATCLLQD--------LKDKVLKSGGKQTRIEMHDLTSVYVLN 188

  Rat   201 VICAICFGRRYDHDDQELLSIVNLSNE-FGEVTGSGYPADFIPILRYL-PN-SSLDAFKDLNKKF 262
            .:..:..||||:....|:..::....| |..:...|......|:||:: || |..:.|.:.::..
  Fly   189 TLWCMLSGRRYEPGSPEITQLLETFFELFKNIDMVGALFSHFPLLRFIAPNFSGYNGFVESHRSL 253

  Rat   263 YSFMKKLIKEH---YRTFEKGHIRDITDSLIEHCQDRRLDENANVQLSDDKVITIVFDLFGAGFD 324
            |:||.|.|:.|   |:.:::.  ||:.||.: ..||...||..  ..||..::.|..|:|.||.:
  Fly   254 YTFMSKEIELHRLTYKNYDEP--RDLMDSYL-RAQDEGNDEKG--MFSDQSLLAICLDMFLAGSE 313

  Rat   325 TITTAISWSLMYLVTNPRIQRKIQEELDTVIGRDRQPRLS-DRPQLPYLEAFILETFRHSSFVPF 388
            |...::.:..|:||..|.||.:..:|:..|:|.:|.|..| ||.:|||.||..||..|......|
  Fly   314 TTNKSLGFCFMHLVLQPEIQERAFQEIKEVVGLERIPEWSRDRTKLPYCEAITLEAVRMFMLHTF 378

  Rat   389 TIPHSTIRDTSLNGFYIPKGHCV-------FVNQWQVNHDQELWGDPNEFRPERFLTSSGTLDKH 446
            .|||..:.||.|:|:.|||...|       .:|...       :.||..|.|:|:|     .|.|
  Fly   379 GIPHRAVCDTRLSGYEIPKDTMVIACFRGMLINPVD-------FPDPESFNPDRYL-----FDGH 431

  Rat   447 LS--EKVILFGLGKRKCIGETIGRLEVFLFLAILLQQMEFNVSPGEKVDMTPAYGLT 501
            |.  |....||.|:.:|:|:.:||..:|:|...:||..:....||:..:..|..|.|
  Fly   432 LKLPEAFNPFGFGRHRCMGDLLGRQNLFMFTTTVLQNFKMVAIPGQVPEEVPLEGAT 488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp1a1	NP_036672.3	Mitochondrial targeting signal. /evidence=ECO:0000269\|PubMed:19401463, ECO:0000269\|PubMed:9348277	33..44		2/6 (33%)
Cyp1a1	NP_036672.3	CYP1A	74..509	CDD:410769	131/455 (29%)
Cyp303a1	NP_001285977.1	p450	28..480	CDD:278495	137/495 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920