DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp11b2 and Cyp301a1

DIOPT Version :9

Sequence 1:	NP_036670.2	Gene:	Cyp11b2 / 24294	RGDID:	2454	Length:	502	Species:	Rattus norvegicus
Sequence 2:	NP_610796.1	Gene:	Cyp301a1 / 36378	FlyBaseID:	FBgn0033753	Length:	553	Species:	Drosophila melanogaster

Alignment Length:	508	Identity:	113/508 - (22%)
Similarity:	204/508 - (40%)	Gaps:	92/508 - (18%)

- Green bases have known domain annotations that are detailed below.

  Rat    26 LGTTATLAPKTLKPFEAIPQYSRNKWLKMIQILREQGQENLHLEMHQAFQELGPIFRHSA--GGA 88
            ||.|..|.|       .|.||:.:...|:..:|.::               .|.|.|...  |..
  Fly    84 LGNTWRLMP-------IIGQYTISDVAKISSLLHDR---------------YGRIVRFGGLIGRP 126

  Rat    89 QIVSVMLPEDAEKLHQVESILPRRMHLEPWVAHRELRGLRR-------GVFLLNGADWRFNRLKL 146
            .::.:...::.||.::.|...|.|..:...|.::.:  :|:       ||..::|..||..|.::
  Fly   127 DLLFIYDADEIEKCYRSEGPTPFRPSMPSLVKYKSV--VRKDFFGDLGGVVGVHGEPWREFRSRV 189

  Rat   147 NPNVLSPKAVQNFVPMVDEVARDFLEALKKKVRQNARGSLTMDVQQSLFNYTIEASNFALFGERL 211
            ...||....::.::..::.:..|||...:..:.:|.  .|..|....:..:::|.........||
  Fly   190 QKPVLQLSTIRRYLQPLEVITEDFLVRCENLLDENQ--ELPEDFDNEIHKWSLECIGRVALDTRL 252

  Rat   212 GLLGHDLNPGS--LKFIHALHSMFKSTTQLLFLPRSLTRWTSTRVWKEHFDAWDVISEYANRCIW 274
            |.|..:|.|.|  .:.|.|.....::.. .|.|.....|:..|.:|..:....:.......:.|.
  Fly   253 GCLESNLKPDSEPQQIIDAAKYALRNVA-TLELKAPYWRYFPTPLWTRYVKNMNFFVGVCMKYIQ 316

  Rat   275 KVHQELRLGSSQTYSG----IVAALITQGALPLDAIKANSMELTAGSVDTTAIPLVMTLFELARN 335
            ...:.|:.......:|    :...:::|....:..|.|  ::|....:||.::.:...|::||..
  Fly   317 SATERLKTQDPSLRAGEPSLVEKVILSQKDEKIATIMA--LDLILVGIDTISMAVCSMLYQLATR 379

  Rat   336 PDVQQALRQETLAAEASIAANPQKAMSDLPL------LRAALKETLRLYP--VGGFLERILNSDL 392
            |..||.:.:|.    ..:..:|...:: :||      |:..:||..|:|.  :|.  .|.|..|.
  Fly   380 PVDQQKVHEEL----KRLLPDPNTPLT-IPLLDQMHHLKGFIKEVFRMYSTVIGN--GRTLMEDS 437

  Rat   393 VLQNYHVPAGTLVLLYLYSMGRNPAVFP-----RPERYM-------PQRWLE--------RKRSF 437
            |:..|.||.|.            .||||     ..|.|:       |:|||:        :...|
  Fly   438 VICGYQVPKGV------------QAVFPTIVTGNMEEYVTDAATFRPERWLKPQHGGTPGKLHPF 490

  Rat   438 QHLAFGFGVRQCLGRRLAEVEMLLLLHHMLKTFQVETLRQEDVQMAYRFVLMP 490
            ..|.:|:|.|.|||||.|::||.:||..:|:.:::| ...:.:..|..|:..|
  Fly   491 ASLPYGYGARMCLGRRFADLEMQILLAKLLRNYKLE-YNHKPLDYAVTFMYAP 542

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp11b2	NP_036670.2	p450	44..498	CDD:278495	107/490 (22%)
Cyp301a1	NP_610796.1	p450	76..530	CDD:299894	110/494 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820