DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Chrnb1 and nAChRbeta1

DIOPT Version :9

Sequence 1:	NP_001382047.1	Gene:	Chrnb1 / 24261	RGDID:	2349	Length:	504	Species:	Rattus norvegicus
Sequence 2:	NP_523927.2	Gene:	nAChRbeta1 / 38545	FlyBaseID:	FBgn0000038	Length:	521	Species:	Drosophila melanogaster

Alignment Length:	508	Identity:	191/508 - (37%)
Similarity:	291/508 - (57%)	Gaps:	64/508 - (12%)

- Green bases have known domain annotations that are detailed below.

  Rat    24 SEAEGQLLKKLFSDYDSSVRPAQEVGDRVGVSIGLTLAQLISLVRENEKDEEMSTKVYLDLEWTD 88
            ||.|.:|::.||..|:..:||.|.:..:|||..||...|||::   |||::.|.:.|:|.|.|.|
  Fly    25 SEDEERLVRDLFRGYNKLIRPVQNMTQKVGVRFGLAFVQLINV---NEKNQIMKSNVWLRLVWYD 86

  Rat    89 YRLSWDPAEHDGIESLRVTAESVWLPDVVLLNNNDGNFDVALDINVVVSFEGSVRWQPPGLYRSS 153
            |:|.||.|::.||..||:..:.||.||:||.||.|||::|....||::...|.|.|.||.:|:||
  Fly    87 YQLQWDEADYGGIGVLRLPPDKVWKPDIVLFNNADGNYEVRYKSNVLIYPTGEVLWVPPAIYQSS 151

  Rat   154 CSIQVTYFPFDWQNCTMVFSSYSYDSSEVSLKTGPDPDGQERQEIYIHEGTFIENGQWEIIHKPS 218
            |:|.|||||||.|.|.|.|.|::::..:|||       .....:.::....:.::|.|:||..|:
  Fly   152 CTIDVTYFPFDQQTCIMKFGSWTFNGDQVSL-------ALYNNKNFVDLSDYWKSGTWDIIEVPA 209

  Rat   219 RLIHLPGDRRGGKEGHREEVIFYLIIRRKPLFYLVNVIAPCILITLLAIFVFYLPPDAGEKMGLS 283
            .|....||.....|   .::.||:|||||.|||.||:|.|.:||:.|.:.|||||.:||||:.|.
  Fly   210 YLNVYEGDSNHPTE---TDITFYIIIRRKTLFYTVNLILPTVLISFLCVLVFYLPAEAGEKVTLG 271

  Rat   284 IFALLTLTVFLLLLADKVPETSLAVPIIIKYLMFTMILVTFSVILSVVVLNLHHRSPHTHQMPFW 348
            |..||:|.|||||::..:|.|||.:|:|.|||:||.|:.|.|::::|:::|.:.|.|.||:||.:
  Fly   272 ISILLSLVVFLLLVSKILPPTSLVLPLIAKYLLFTFIMNTVSILVTVIIINWNFRGPRTHRMPMY 336

  Rat   349 VRQIFIHKLPPYLGLKRPKPER----DQLP------EPHHSF-SPRS--------GWGRGTDEYF 394
            :|.||:|.||.:|.:|||:..|    .::|      .||.|: ||..        |..:...|..
  Fly   337 IRSIFLHYLPAFLFMKRPRKTRLRWMMEMPGMSMPAHPHPSYGSPAELPKHISAIGGKQSKMEVM 401

  Rat   395 ----IRKPPCDFLFPKLNR-------------FQPESPAPDLRRFIDGPPRAVGLPQELREVISS 442
                :..|.|     |:||             .:.||.:.|          ::.|..|..:...:
  Fly   402 ELSDLHHPNC-----KINRKVNSGGELGLGDGCRRESESSD----------SILLSPEASKATEA 451

  Rat   443 ISYMARQLQEQEDHDALKEDWQFVAMVVDRLFLWTFIVFTSVGTLVIFLDATY 495
            :.::|..|:.::.:...:|||::||||:|||.|:.|.:.|:.||:.|.:||.:
  Fly   452 VEFIAEHLRNEDLYIQTREDWKYVAMVIDRLQLYIFFIVTTAGTVGILMDAPH 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Chrnb1	NP_001382047.1	LGIC_ECD_nAChR_B1	27..248	CDD:349825	88/220 (40%)
		Neur_chan_memb	255..490	CDD:397193	92/270 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	365..384		9/29 (31%)
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:273305	189/502 (38%)
		Neur_chan_LBD	28..236	CDD:280998	88/220 (40%)
		Neur_chan_memb	243..498	CDD:280999	92/269 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	4	3.770