DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cel and Nlg3

DIOPT Version :9

Sequence 1:	NP_058693.2	Gene:	Cel / 24254	RGDID:	2331	Length:	612	Species:	Rattus norvegicus
Sequence 2:	NP_001036685.2	Gene:	Nlg3 / 40912	FlyBaseID:	FBgn0083963	Length:	1159	Species:	Drosophila melanogaster

Alignment Length:	716	Identity:	186/716 - (25%)
Similarity:	286/716 - (39%)	Gaps:	179/716 - (25%)

- Green bases have known domain annotations that are detailed below.

  Rat    15 LAAACAAKLGAVYTEGGFVEGVNKKLSLLGGDSVDIFKGIPFATAKT----LENPQRHPGWQGTL 75
            |.|..::::  :.|..|.:.||..:|.....|.|:.::|||:|:...    ...|.....|.|..
  Fly   149 LPAQLSSRI--INTRNGAISGVIVQLDGRHLDPVEAYRGIPYASPPVGNLRFMPPVSAAMWSGVK 211

  Rat    76 KATDFKKRCLQATITQDDTYGQ--------------------------EDCLYLNIWVP------ 108
            ||..|...|.|..   .|.:.:                          ||||||||:||
  Fly   212 KADRFSPVCPQRL---PDIHNETAALERMPKGRLEYLKRLLPYLQNQSEDCLYLNIYVPIQVGSR 273

  Rat   109 --QGRKQVSH-------------------------------DLPVMVWIYGGAFLMGSGQGANFL 140
              .|....|.                               ..||:|:::|.::...||..
  Fly   274 DSSGSSSSSSAGSSSSGSGGSSSSSSSSSTSSSSAGSGSPAKYPVLVFVHGESYEWNSGNP---- 334

  Rat   141 KNYLYDGEEIATRGNVIVVTFNYRVGPLGFLSTGD---ANLPGNFGLRDQHMAIAWVKRNIAAFG 202
                |||..:|:.|.::|||.|||:|.||||:...   :.||.|:||.|...|:.|:|.||||||
  Fly   335 ----YDGSVLASYGQILVVTINYRLGVLGFLNANTDRYSKLPANYGLMDIIAALHWLKENIAAFG 395

  Rat   203 GDPDNITIFGESAGAASVS--LQTLSPYNKGLIRRAISQSGVALSPWAIQENPLFWAKTIAKKVG 265
            |||::||:.|...|||.|.  :.:::.....|..|||..||..|:||::..||..:|..:|..|.
  Fly   396 GDPNSITLAGHGTGAACVHFLISSMAVPEGLLFNRAILMSGSGLAPWSLVSNPAKYAAIVAHHVN 460

  Rat   266 CPTE-DTAKMAGCLKITDPRALTLAYRLPLKSQEYPIVHYLAFIPVVD------GDFIPDDPINL 323
            |.:: ..|.:..||:   .:.|.....:|::..|:.    .||.|.:|      ||::|..|.:.
  Fly   461 CASDLPHAHLMKCLR---EKTLDQLLSVPIRPPEFG----FAFGPSIDGVVIDGGDYVPPAPGSP 518

  Rat   324 YDNA-ADIDYLAGINDMDGHL----------------FATVDVPAIDKAKQ-----DVTE-EDFY 365
            ...| |.....|| |.:.|..                ...:...||:|..:     .||. |.|:
  Fly   519 AAQAQAQASTAAG-NGLGGEAGIAAAGGWGTPGQLENIVLMRKTAINKLSRYDLMAGVTRAEAFF 582

  Rat   366 RLVSGHT-----------VAKGLKGTQATFDI----------YTESWAQDPSQE--NMKKTVVAF 407
            ...||..           :.|.......||.:          ||: | :.|.|.  |::...:..
  Fly   583 SFNSGDVQYGIEADRRSRILKAYVRNTYTFHLNEIFATIVNEYTD-W-ERPVQHPINIRDETLEA 645

  Rat   408 ETDILFLIPTEMALAQHRAHAKSAKTYSYLFSHPSRMPIYPKWMGADHADDLQYVFGKPFATPL- 471
            .:|...:.|....:..|.|..::  :|.|:|.:.:|...||:..|..|.:||.|:||.|.....
  Fly   646 LSDAQVVAPAAQTVDLHSADHRN--SYLYVFDYQTRFGDYPQRQGCIHGEDLPYIFGAPLVGGFN 708

  Rat   472 ----GYRAQDRTVSKAMIAYWTNFAKSGDPN----------MGNSPVPT-HWYPYTTENGNYLDI 521
                .|...:.::|:.::.||:||.::|:||          ...|...| .|..|.:.:..||:.
  Fly   709 HFTRNYTKTEISLSEVVMFYWSNFVRTGNPNEQMETEHGSRQERSRYKTIEWTAYESVHKKYLNF 773

  Rat   522 NKKITSTSMKEHLREKFLKFWAVTFEMLPTVVGDHTPP------EDDSEAAPVPPTDDSQVVPVP 580
            :   |...:|.|.|...|.||......|....||:.|.      :||.|...:|  .|:.|.|:.
  Fly   774 D---TKPKLKNHYRAHRLSFWLNLIPDLHKPGGDNVPAAHHQLHDDDDEDNNIP--SDASVKPLN 833

  Rat   581 P 581
            |
  Fly   834 P 834

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cel	NP_058693.2	COesterase	26..542	CDD:278561	170/658 (26%)
		Aes	<118..>247	CDD:223730	54/133 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	553..612		11/35 (31%)
		4 X 11 AA tandem repeats, O-glycosylated region	556..599		9/32 (28%)
Nlg3	NP_001036685.2	COesterase	151..791	CDD:278561	171/667 (26%)
Nlg3	NP_001036685.2	Aes	<313..>410	CDD:223730	43/104 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR43903
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910