DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Camk2b and CaMKI

DIOPT Version :9

Sequence 1:	XP_006251232.1	Gene:	Camk2b / 24245	RGDID:	2262	Length:	666	Species:	Rattus norvegicus
Sequence 2:	NP_524622.1	Gene:	CaMKI / 43792	FlyBaseID:	FBgn0016126	Length:	405	Species:	Drosophila melanogaster

Alignment Length:	382	Identity:	145/382 - (37%)
Similarity:	206/382 - (53%)	Gaps:	36/382 - (9%)

- Green bases have known domain annotations that are detailed below.

  Rat    12 DEYQLYEDIGKGAFSVVRRC-VKLCTGHEYAAKIINTKKLSARDHQKLEREARICR--------- 66
            ::|.|:..:|.||||.||.. .|...|..:|.|||:.|.|..:: :.||.|.|:.|
  Fly    29 EKYNLHGLLGTGAFSEVRLAESKDSPGEHFAVKIIDKKALKGKE-ESLENEIRVLRRFSANHFDG 92

  Rat    67 ------LLKHSNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVL 125
                  .|.|.|||:|.::..::...|||.:||||||||:.||.:..|:|.||||.|:||||||.
  Fly    93 KCLNGTRLTHPNIVQLLETYEDKSKVYLVMELVTGGELFDRIVEKGSYTEKDASHLIRQILEAVD 157

  Rat   126 HCHQMGVVHRDLKPENLLLASKCKGAAVKLADFGLA-IEVQGDQQAWFGFAGTPGYLSPEVLRKE 189
            :.|:.|||||||||||||..|....:.:.::||||: :|..|....   ..|||||::||||.::
  Fly   158 YMHEQGVVHRDLKPENLLYYSPDDDSKIMISDFGLSKMEDSGIMAT---ACGTPGYVAPEVLAQK 219

  Rat   190 AYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLT 254
            .|||.||:|:.|||.||||.|||||:||:...|:.||..|.::|.||.||.::..||:.|..::.
  Fly   220 PYGKAVDVWSIGVISYILLCGYPPFYDENDANLFAQILKGDFEFDSPYWDEISESAKHFIKNLMC 284

  Rat   255 INPAKRITAHEALKHPWVCQRSTVASMMHRQETV-ECLKKFNARRKLKGAILTTML--------- 309
            :...||.|..:||.|.|:......:..:|  .|| |.|||..|:.:.|.|.....:
  Fly   285 VTVEKRYTCKQALGHAWISGNEASSRNIH--GTVSEQLKKNFAKSRWKQAYYAATVIRQMQRMAL 347

  Rat   310 ---ATRNFSVGRQTTAPATMSTAASGTTMGLVEQAKSLLNKKADGVKPQTNSTKNSS 363
               :..||.....:...:|..|||:|.....|..::..:...|..:.....||..:|
  Fly   348 NSNSNANFDSSNSSNQDSTTPTAATGAWTSNVLSSQQSVQSHAQEMNKSGGSTNAAS 404

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Camk2b	XP_006251232.1	STKc_CaMKII	12..303	CDD:270988	132/308 (43%)
Camk2b	XP_006251232.1	CaMKII_AD	534..661	CDD:285524
CaMKI	NP_524622.1	STKc_CaMKI	27..301	CDD:270985	122/275 (44%)
CaMKI	NP_524622.1	S_TKc	31..302	CDD:214567	122/274 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D330091at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X46
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920