Protein Alignment C4a and Tep1

DIOPT Version :9

• Sequence 1: NP_113692.2
• Gene: C4a / 24233
• RGDID: 620005
• Length: 1737
• Species: Rattus norvegicus
• Sequence 2: NP_523578.1
• Gene: Tep1 / 34937
• FlyBaseID: FBgn0041183
• Length: 1354
• Species: Drosophila melanogaster
• Alignment Length: 1560
• Identity: 363/1560 - (23%)
• Similarity: 611/1560 - (39%)
• Gaps: 398/1560 - (25%)

  Rat   115 LKNTASKATETQ-GVNLLFSSRRGHIFVQTDQPIYNPGQRVRYRVFALDQKMRPSTDTLTVTVEN 178
            ||...|...|.| ...|.|:.....:::|:|:..|.||.::::||..||:..||:.....:.:|.
  Fly    91 LKVMGSGGIEFQNSTKLSFAPDLNWLYIQSDKATYKPGDKIQFRVLFLDKNTRPAVIDKPIKIEI 155

  Rat   179 SHG---LRVRKKEVFAPTSIFQDDFIIPDISEPGTWKISARFSDGLESNRSTHFEVKKYVLPNFE 240
            ..|   |....|::.....::..:..:.|....|.|.::|...|  |...:....|.|||:|.||
  Fly   156 RDGDQNLIKSWKDIKPAKGVYSGELQLSDRPVLGNWTVTATVQD--EGKVTNVLVVDKYVVPKFE 218

  Rat   241 VKLTPWKPYILTVPSYREEIQLDVQARYVYGKPVQG-VAYTRFALMDEQGKKSFLRGLETQTKL- 303
            |.:...|    .|.:....|:..::|||.:.|||:| |..|             :.|..|:..|
  Fly   219 VVVLTAK----NVAASAGYIRATIKARYTFKKPVKGHVVAT-------------IEGSSTEQSLP 266

  Rat   304 VEGQTH----ISISRDQFQAALGKVNTEIGDLE--GLRLYAAVAVIESPGGEMEEAELTSWPFVS 362
            ::|:.:    ||.:..:.......|..|:.|::  |    .|...:.....::|:   ..||
  Fly   267 IDGEVNVEFPISATAKRLLKITAIVTEELTDIKHNG----TAYVTVHQHRHKLED---LFWP--- 321

  Rat   363 SAFSLDLSHTKQHLVPGAPFLLQALVREMSGSEASDVPVKVSATLLSGSDSKVLDF-----QQNT 422
                       .|..||.....:.:||.:.||...|             .||:::|     |.:.
  Fly   322 -----------THYRPGVSSEFKTVVRNLDGSPVMD-------------SSKMVNFNVLCCQVSK 362

  Rat   423 NGIGQVSFSI---HVP-PTITELRLLVS----AGSLYPAVAKLTVQAPPSRGPGFLSIEPL---- 475
            |....:..||   |:. |...:..|:.|    |.::...:.||.              :||
  Fly   363 NFSASLQNSIATEHIMLPETCQSCLVTSTFDTAENIERYIYKLN--------------KPLMIAI 413

  Rat   476 DLRSPRVGDTFVLSLRTVGIPMPTFSHYYYM-IISRGQI-MAMSREPRRALTSISVLVDHHLAPS 538
            :.:.|:     :..|..:.|...|:..|:.: :::||.| :::.:|.:....|..:    ...|:
  Fly   414 NTKKPQ-----LRKLLKINIISDTYLPYFILTVVARGNIVLSLFQEMKEKKKSQEI----EFEPT 469

  Rat   539 FYFV---AYFYH---QGLPVANSLLINVQPGDCEGKLELKVDGAKEYRNGDSMKLQLQTDSEALV 597
            |..|   ..|.|   .|:.:::...:::: .|.|..:|:..  ..|....|.:.|:::|:..:.|
  Fly   470 FALVPQATIFVHYIIDGVLMSDEKTVDIE-RDFENTIEILT--TNEALPRDEVSLKVKTNPHSFV 531

  Rat   598 ALGAVDTALYAVGGRSHKPLDMSKVFEVMNSYNLGCGPGGGDDALQVFQTAGLAFSDGDRLTQTK 662
            .|..||.::..:  ||...|:...:...:.:|:                      :|...||..
  Fly   532 GLLGVDQSVLLL--RSGNDLNRDLILNNLATYS----------------------TDLVILTNA- 571

  Rat   663 ENLSCPKEKKSRQKRNVNFQKAISEKLGQYSSPDTKRCCQDGMTKLPMARTC---EQRAARVPQP 724
                           |:|..::..   |.|::|....|     |...:.||.   |......|.|
  Fly   572 ---------------NINIYRSSG---GCYTNPGYTNC-----TGSLIGRTMFKNEPTKNSGPVP 613

  Rat   725 ACREPFLSCCKFAEDLRRNQTRSQAGLARAQDMLQEEDLIDEDDILVRSFFPENWLW-RVEPV-- 786
            ..                ..||:||.|..                 ||..|||.||: .:..|
  Fly   614 IV----------------GSTRAQASLPP-----------------VRKLFPETWLFSNITDVGA 645

  Rat   787 DRSKLLTVWLPDSLTTWEIHGVSLSKSKGLCVAK-PTRVRVFREFHLHLRLPISVRRFEQLELRP 850
            :...::...:||:||:|.|.|.|||...||.|.: |:|:|||:.|.:...||.||:|.|.:.:..
  Fly   646 NGEYIIKETVPDTLTSWVITGFSLSPQSGLAVTRNPSRIRVFQPFFITTNLPYSVKRGEVIAIPV 710

  Rat   851 VLYNYLSEDVTVSVHVSPVEGLC------------LAGGGLLAQQVSVPAGSARPVAFSVVPTAA 903
            :::|||..||...|.:...:|..            ...|....:.:.:||.:.|.::|.:.|...
  Fly   711 IVFNYLGMDVKAKVLMDNSDGQYEFIETTNKNVSQYLRGVRRKKTLWIPANTGRGISFMIRPKKV 775

  Rat   904 ASIPLKVVARGSFTIGDAVSKILQIEKEGA--IHREEIVYNLDPLNNLGRSLEIPGSS-----DP 961
            ....||:.|...:. ||.:.:||::|.:|.  ...:.::.|:..||.  |||..|..:     ..
  Fly   776 GLTTLKITAISKYA-GDRLHQILKVEADGVQKYVNKAVLINVQRLNR--RSLAPPEKTIIIEKAD 837

  Rat   962 NVIPDGDFSSFVRVTASEPLETLGSEGALSPGGVASLLRLPRGCAEQTMIYLAPTLTASHYL--- 1023
            |||...:...|         |..|:..|.....:..|:.||.||.||.|....|::.|..||
  Fly   838 NVIEGSETVEF---------EVCGTSQAPQLEHLDDLVHLPCGCGEQNMFNFVPSILALSYLKAK 893

  Rat  1024 DRTEQWSKLPPETKDHAVDLIQKGHMRIQQFRKKDGSFGAWLHRDS--STWLTAFVLKILSLAQE 1086
            :|.:|      |.::.|...::.|:.....:::.||||.||...|:  ||||||:|::....|.:
  Fly   894 NRQDQ------EIENKAKRYVETGYQIELNYKRNDGSFSAWGQHDALGSTWLTAYVIRSFHQAAK 952

  Rat  1087 QIGDSPEKLQETAGWLLGQQLDDGSFHDPCPVIHRGMQGGLVGTDETVALTAFVVIALHHGLAVF 1151
            .|......|.....:|:.:|..||.|.:...|||......|       |||:||:      |..|
  Fly   953 YIDIDKNVLVAGLDFLVSRQSTDGKFKELGMVIHNSHGSPL-------ALTSFVL------LTFF 1004

  Rat  1152 QDENSQQLKKRVEASITKANSFLGQKASAGLLGAHAS------AITAYALTLTKASEDLRNV--A 1208
            ::|......|.|   |.:|..|:       :...|.|      ||.|.||:|.:.    ||.  .
  Fly  1005 ENEEYMPKYKHV---IDRAVEFV-------VTEVHQSNEPYDLAIAALALSLARN----RNAYKV 1055

  Rat  1209 HNSLMAMAEETGENLYWGSAIGSQDNVVSSTPAPRNPSEPVPQAPALWIETTAYGLLHLLLREGK 1273
            .:.|..:|...|::.:|   .|| |...||.                 :|||:|.||.||    :
  Fly  1056 LDKLDKLATRRGDHKWW---TGS-DKCKSSE-----------------VETTSYVLLALL----E 1095

  Rat  1274 GEMADK---VATWLTHQGSFQGGFRSTQDTVVTLDALSAYWIASHTTEEKALNVTLSSMGRNGYK 1335
            ..::|:   :..||..:.:..|||.|:|||||.:.||:.|.:.||.:.| |:::....:  |..|
  Fly  1096 HNISDEPKPIVDWLISKRNSNGGFVSSQDTVVGIMALTKYELQSHASTE-AIDIEFWHL--NEDK 1157

  Rat  1336 SHLLQLNNHQVKGLEEELKFSLGSTINVKVGGNSKGTLKILRTYNVLDMKNTTCQDLRIEVTVTG 1400
            .|:.....::.|....:|.   .:|..||:....:|..::..||.
  Fly  1158 KHVRVTKENEFKVQTHQLP---ENTNEVKLLAKGQGRAQVQLTYR-------------------- 1199

  Rat  1401 YVEYTREANEDYEYDYDMPAADDPSVHSQPVTPLQLFEGRRSRRRR--------EAPKAADEQES 1457
            |...|:||...::....:                     ::|.:.|        ..|.||.|:..
  Fly  1200 YNVATKEARPSFKLTTTV---------------------KKSHKGRLILGICGTYTPIAASERNK 1243

  Rat  1458 RVQYTVCIWRNGNLGLSGMAIADITLLSGFQALRADLE---KLTSLSDRYVSHFET--DGPHVLL 1517
                           .:.||:..:.|.||:.   .|:|   .:.::||  |...||  :...|.:
  Fly  1244 ---------------TTNMALMQVQLPSGYV---CDIEPFADIEAISD--VKRVETKNEDTEVHI 1288

  Rat  1518 YFDSV-PTTRECVGFGALQEVAVGLVQPASAVLYDYYSPDHKCSVFYAAPTKSKLLSTLCSADVC 1581
            ||:.: |..|:|:...|:...||..::|:...|||||:.:...:.||...|      :||  |:|
  Fly  1289 YFEKLSPGDRKCLTLEAIYTHAVANLKPSWVRLYDYYATERSATEFYHVDT------SLC--DIC 1345

  Rat  1582  1581
              Fly  1346  1345

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
C4a	NP_113692.2	A2M_N	139..231	CDD:280081	21/94 (22%)
		A2M_N_2	475..608	CDD:285005	28/144 (19%)
		ANATO	684..752	CDD:237984	14/70 (20%)
		A2M	779..866	CDD:278630	34/90 (38%)
		complement_C3_C4_C5	991..1310	CDD:239226	97/334 (29%)
		A2M_comp	1046..1312	CDD:284982	82/278 (29%)
		A2M_recep	1474..1563	CDD:284981	27/94 (29%)
		NTR_complement_C4	1581..1735	CDD:239639	1/1 (100%)
Tep1	NP_523578.1	A2M_N	116..201	CDD:280081	20/86 (23%)
		A2M_N_2	411..542	CDD:285005	27/142 (19%)
		A2M	634..726	CDD:278630	34/91 (37%)
		A2M_2	859..1135	CDD:239227	97/333 (29%)
		A2M_comp	910..1135	CDD:284982	81/276 (29%)
		A2M_recep	1245..1335	CDD:284981	27/94 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343878
Domainoid	1	1.000	50	1.000	Domainoid score	I11352
eggNOG	1	0.900	-	-		E1_COG2373
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177369at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11412
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.850