Protein Alignment C4a and Tep3

DIOPT Version :9

• Sequence 1: NP_113692.2
• Gene: C4a / 24233
• RGDID: 620005
• Length: 1737
• Species: Rattus norvegicus
• Sequence 2: NP_523507.2
• Gene: Tep3 / 34045
• FlyBaseID: FBgn0041181
• Length: 1469
• Species: Drosophila melanogaster
• Alignment Length: 1678
• Identity: 400/1678 - (23%)
• Similarity: 643/1678 - (38%)
• Gaps: 401/1678 - (23%)

  Rat    25 LFSPSVVNLGTPLSVGVQLLDAPAGQEVK----GSVYLRNPTSGPCSPKKDFKLSSGNDF--VLL 83
            :.:|:.:...:...|.|.|.:||.....|    ||.|            .|||......|  .||
  Fly    33 IIAPNTLRPNSQFHVAVSLHNAPESATFKVGILGSSY------------TDFKTVELRPFSTQLL 85

  Rat    84 RLEVPLKDVRSCGLFGLRRAPHIQLVAHSPWLKNTASKATETQGVNLLFSSRRGHIFVQTDQPIY 148
            ..|:|           ..|....:|.|..   ........|||   |.|.|::..:.||||:.||
  Fly    86 HFEIP-----------ALRTDRYRLTAEG---LGGVQFTNETQ---LHFESKQHTVLVQTDKSIY 133

  Rat   149 NPGQRVRYRVFALDQKMRPST--DTLTVTVENSHGLRVRK-KEVFAPTSIFQDDFIIPDISEPGT 210
            .||..|.|||..||..::|:.  ..:.|.:::|....:|. |::....||:.::..:.|....||
  Fly   134 KPGDLVHYRVLILDANLKPARGYGRVHVDIKDSGDNIIRSYKDIRLTNSIYSNELRLSDSPRFGT 198

  Rat   211 WKISARFSDGLESNRSTHFEVKKYVLPNFEVKLTPWKPYILTVPSYRE-EIQLDVQARYVYGKPV 274
            |.|....||   ...:..||:..::||.|.|.:...|..|     |:: :|...|:|.|.:|:|:
  Fly   199 WSIVVDVSD---QEHTQTFEILDHILPKFVVDIDTPKHAI-----YKDGKIAATVRAHYAFGQPI 255

  Rat   275 QGVA----YTRFALMDEQGKKSFLRGLETQTKL-VEGQTHISISRDQFQAALGKVNTEI---GDL 331
            .|.|    |..|.    ...:.|:..|.|:..: ::|..:....          :..|:   .|.
  Fly   256 VGEATLSIYPTFF----GSLQPFVNDLITRKVVPIDGNAYFEFD----------IENELHLKQDY 306

  Rat   332 EGLRLYAAVAVIESPGGEMEEAELTSWPFVSSAFSLDLSHTK-------QHLVPGAPFLLQALVR 389
            |  |.|...|::       ||....|....|:..:|.|:|.:       .:.:||.||...|.:.
  Fly   307 E--RQYLLDALV-------EEKSTGSVQNYSTVLTLHLNHYRVEAVKVPSYYIPGVPFEATARIA 362

  Rat   390 EMSGSEASDVPVKVSATLLS--GSDSKVLDFQQNTNGIGQVSFSIHVPPTITEL----RLLVSAG 448
            ...|.:..|...:::|.|.:  ||.........:.:..|::.....||  |.:.    .::|...
  Fly   363 RNDGGQLRDFNPQITAYLTNVYGSSEMYNRTAYSLDASGEIKMKFTVP--IGDRDEFHSIIVDYQ 425

  Rat   449 SLYPAVAKLTVQAPPSR---GPGFLSIEPLDLRSPRVGDTFVLSLRTVGIPMPTFSHYYYMIISR 510
            .:...|.|:     ||:   ...:::.:.|:.| |.|.....:.:|:    .....::.|.::.|
  Fly   426 GVISEVGKI-----PSKHLHSKNYITAKVLNDR-PTVNQEISVVVRS----FAPIKYFMYQVVGR 480

  Rat   511 GQIMAMSREPRRALTSISVLVDHHLAPSFY----FVAYFYHQGLPVANSLLINVQPGDC---EGK 568
            |.|: :||.           ||  :||..:    |:|.|  ..:|.||.|:..|..|:.   |..
  Fly   481 GDII-LSRN-----------VD--VAPGTFHTIKFLASF--AMMPRANLLVYTVIDGEFVYDEQV 529

  Rat   569 LEL--------KVDGAKEYRNGDSMKLQLQTDSEALVALGAVDTALYAVGGRSHKPLDMSKVFEV 625
            ::|        :||.......|..:.:.:.|...:.|.|..||.  .|...||...|...::.:.
  Fly   530 IQLEENLLNAVQVDAPIRAPPGQDIDIGISTKPYSYVGLMLVDQ--NANDLRSGHDLTHKRLMDA 592

  Rat   626 MNSYNLGCGPGGGDDALQVFQTAGLAFSDGDRLTQTKENLSCPKEKKSRQKRNVNFQKAIS---- 686
            :.||.|.          .|....|....:...:|.:..:....||.:|    |....:.:|
  Fly   593 LRSYELS----------DVNTPMGSPGKESGVITMSNTDYFIEKEAES----NPALDREVSTGPE 643

  Rat   687 -EKLGQYSSPDTKRCCQDGMTKLPMARTCEQRAARVPQPACREPFLSCCKFAEDLRRNQTRSQAG 750
             :||......|.....:..:..||..:. ....:..|:|....|           |.:..|..|
  Fly   644 EDKLTTVRKTDIGPAHKIEVNTLPPGKG-RYAFSYTPKPFWHNP-----------RVHVMRDPA- 695

  Rat   751 LARAQDMLQEEDLIDEDDILVRSFFPENWLWR--VEPVDRSKLLTVWLPDSLTTWEIHGVSLSKS 813
                                      :.||:.  ....|....:...:|..:|:|.:...:|...
  Fly   696 --------------------------DTWLFLNISASSDGRNSIHRRIPSEMTSWVVSAFALDPV 734

  Rat   814 KGLCVAKPT-RVRVFREFHLHLRLPISVRRFEQLELRPVLYNYLSEDVTVSV------------H 865
            .||.::.|. ::..::||::...||.|::|.|.:.:..|::|....|:.|.|            .
  Fly   735 NGLGLSPPNGKLEAYKEFYISTELPYSIKRDELIAIPFVVHNNRDSDLNVEVTFYNSALDFDFPQ 799

  Rat   866 VSP-------VEGLCLAGGGLLAQQ-VSVPAGSARPVAFSVVPTAAASIPLKVVARGSFTIGDAV 922
            :.|       ||        |..:: :.||..|||.|:|.|.|.....:.:|.:|..| ..||.|
  Fly   800 LDPKATNQPKVE--------LYRRRSLQVPGRSARSVSFIVTPKRVGPLLVKAMAASS-QAGDTV 855

  Rat   923 SKILQIEKEGAIHREE----IVYNLDPLNNLGRSLEIPGSSDPNVIPDGDFSSFVRVTASEPLET 983
            .:.|.:|..||:.|..    ...|.:..|....::.:|    .|.||:.     .|:..|...:.
  Fly   856 EQNLLVEHPGAMERINRGFLFELNSNAQNRRNVTIAVP----RNAIPES-----TRIEVSAVGDL 911

  Rat   984 LGSEGALSPGGVASLLRLPRGCAEQTMIYLAPTLTASHYLDRTEQWSKLPPETKDHAVDLIQKGH 1048
            :||    ..|.:.||:.||.||.||||:...|.|....||.|..|   |.||.:..|.:.:..|:
  Fly   912 IGS----LVGNLDSLILLPTGCGEQTMVNFVPNLIVLRYLGRLRQ---LTPEVELRATNNLAIGY 969

  Rat  1049 MRIQQFRKKDGSFGAW---LHRDSSTWLTAFVLKILSLAQEQIGDSPEKLQETAGWLLGQQLDDG 1110
            .||..:|.::|:|.|:   :.| |||||||:|.:.|..|..........||:...:|...|..:|
  Fly   970 QRILYYRHENGAFSAFGLDIKR-SSTWLTAYVARSLRQAAPFTQVDSNVLQKALTYLGSVQSANG 1033

  Rat  1111 SFHDPCPVIHRGMQGGLVGTDETVALTAFVVIALHHGLAVFQDENSQQLKKRVEASITKANSFLG 1175
            .|.:...|..|      .| |:.::|||||.:||...:.::.:..:         :|.||..|:
  Fly  1034 GFEERGDVFER------FG-DDGISLTAFVTLALMENVDLYPEYRN---------NINKALDFI- 1081

  Rat  1176 QKASAGLLGA---HASAITAYALTLTKASEDLRNVAHNSLMAMAEETGENLYWGSAIGSQDNVVS 1237
               :.||.|:   ||.||..|  .|::|:.:.:......|.:||.......:|
  Fly  1082 ---TRGLDGSSNLHAMAIGTY--VLSRANHNAKAAFLQRLDSMATNKDGLKWW------------ 1129

  Rat  1238 STPAPRNPSEPVPQAPALW--------IETTAYGLLHLLLREGKGEMADKVATWLTHQGSFQGGF 1294
                  |.:.|..:..:.|        ||.:||..|.||.....|: |..|..||..|.:.:|||
  Fly  1130 ------NKTAPAGEQQSPWYNATRSVNIEISAYAALALLENNLVGD-ALPVLNWLMDQRNPKGGF 1187

  Rat  1295 RSTQDTVVTLDALSAYWIASHTTEEKALNVTLSSMGRNGYKSHLLQLNNHQVKGLEEELKFSLGS 1359
            .::|||||.|.||..:       .|:     .||.|.|      ||:..|..:|.|        :
  Fly  1188 VASQDTVVGLQALLMF-------AER-----FSSQGNN------LQIGFHYGEGAE--------T 1226

  Rat  1360 TINVKVGGNSKGTLKILRTYNVLDMKNTTCQDLRIEVTVTGYVEYTREANEDYEYDYDMPAA--- 1421
            .|||    |::.:|.:.......::||       :.|:.||  .....|...|.|:.::.:|
  Fly  1227 IINV----NAENSLALQTVELPNNLKN-------LSVSATG--RGMALAQVSYTYNTNVTSAWPR 1278

  Rat  1422 --DDPSVHSQPVTPLQLFEGRRSRRRREAP-----------KAADEQESRVQYTVCIWRNGNLGL 1473
              .||:|:                |...|.           ....|.|.|
  Fly  1279 FVLDPTVN----------------RNSHADYLHLSACASFVSVVGENEQR--------------- 1312

  Rat  1474 SGMAIADITLLSGFQALRADLEKLTSLSDRYVSHFETDGPH--VLLYFDSVPTTRECVGFGALQE 1536
            |.||:.::.|.|||...|..|..|.| |:| :...||...:  |::|||.:.....|....|.:.
  Fly  1313 SNMAVMEVHLPSGFVVDRDTLPTLES-SER-IKKVETQNRNTKVVIYFDYLDRREVCPTLHAYKT 1375

  Rat  1537 VAVGLVQPASAVLYDYYSPDHKCSVFYAAPTKSKLLSTLCS----ADVCQCAE 1585
            |.|...:|.:.|:||||....:...||.|| ||.:.. :|.    .|:|:.||
  Fly  1376 VKVTKHRPVAVVMYDYYDSARRARQFYRAP-KSNICD-ICEHANCGDLCEKAE 1426

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
C4a	NP_113692.2	A2M_N	139..231	CDD:280081	29/94 (31%)
		A2M_N_2	475..608	CDD:285005	34/147 (23%)
		ANATO	684..752	CDD:237984	12/72 (17%)
		A2M	779..866	CDD:278630	22/101 (22%)
		complement_C3_C4_C5	991..1310	CDD:239226	101/332 (30%)
		A2M_comp	1046..1312	CDD:284982	80/279 (29%)
		A2M_recep	1474..1563	CDD:284981	29/90 (32%)
		NTR_complement_C4	1581..1735	CDD:239639	3/5 (60%)
Tep3	NP_523507.2	A2M_N	124..215	CDD:280081	28/93 (30%)
		A2M_N_2	448..573	CDD:285005	33/145 (23%)
		A2M	697..787	CDD:278630	21/89 (24%)
		A2M_2	918..1203	CDD:239227	100/329 (30%)
		A2M_comp	967..1200	CDD:284982	78/274 (28%)
		A2M_recep	1313..1402	CDD:284981	29/90 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343879
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2373
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177369at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11412
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.850