Protein Alignment C4a and Tep2

DIOPT Version :9

• Sequence 1: NP_113692.2
• Gene: C4a / 24233
• RGDID: 620005
• Length: 1737
• Species: Rattus norvegicus
• Sequence 2: NP_523506.1
• Gene: Tep2 / 34044
• FlyBaseID: FBgn0041182
• Length: 1420
• Species: Drosophila melanogaster
• Alignment Length: 1691
• Identity: 417/1691 - (24%)
• Similarity: 692/1691 - (40%)
• Gaps: 431/1691 - (25%)

  Rat    29 SVVNLGTPLS-------VGVQLLDAPAGQEVKGSVYLRNPTSGPC-SPKKDFKL---SSGN-DFV 81
            |||..||..|       |.|...|.|:  ::|.|:      :||. :..|..:|   |:.| :|.
  Fly    24 SVVGPGTLRSNSKYNVVVSVHKADGPS--QIKVSL------NGPSYNETKQIELPPMSTQNVEFE 80

  Rat    82 LLRLEVPLKDVRSCGLFGLRRAPHIQLVAHSPWLKNTASKATETQGVNLLFSSRRGHIFVQTDQP 146
            :.:|.....::.:.|:.|:             ..||:         ..|.::.::..:|||||:.
  Fly    81 VPKLATGNYNLSAEGVSGV-------------VFKNS---------TKLNYADKKPSVFVQTDKA 123

  Rat   147 IYNPGQRVRYRVFALDQKMRPSTDTLTVTVENSHGLRVRKK---EVFAPTSIFQDDFIIPDISEP 208
            .|.|...|::|:..||:..||:.....::|....|.:.|.|   :|.....:|..:..:.:....
  Fly   124 TYKPADLVQFRILFLDENTRPAKIEKPISVIIIDGAQNRIKQLSDVKLTKGVFSGELQLSEQPVL 188

  Rat   209 GTWKISARFSDGLESNRST-HFEVKKYVLPNFEVKLTPWKPYILTVPSYREEIQLDVQARYVYGK 272
            ||||||... ||  .||.| .|||.|||||.|||.:...|..::.    .:.|:..::|:|.|||
  Fly   189 GTWKISVSV-DG--DNRETKSFEVDKYVLPKFEVIVDTPKAVVIA----DKVIKATIRAKYTYGK 246

  Rat   273 PVQGVA-------YTRFALMDEQGKKSFLRGLETQTKLVEGQTHISI------SRDQFQAALGKV 324
            ||:|.|       |..|..::..|.|      :.:|..|:|:.|:..      .|.|:
  Fly   247 PVKGKATVSMERSYGYFGDLNANGNK------QEKTIDVDGKGHVEFDIIHWAQRGQY------- 298

  Rat   325 NTEIGDLEGLRLYAAVAVIESPGGEMEEAELTSWPFVSSAFSLDLSHTKQHLVPGAPFLLQALVR 389
                  |..::|:|.|.  |...|..:.|..|. ......:|::.....:|......|:.|.:|:
  Fly   299 ------LPPIKLFAVVT--EELTGNKQNATATV-VLHQQRYSIEPYERPEHFEANKSFIYQVVVK 354

  Rat   390 EMSGSEASDVPVKVSA-TLLSGSDSKVLDFQQ-------------NTNGIGQVSFSIHVPPTITE 440
            .:.||     ||..|| .:..|.|.....|.:             |.|||  .:|::.:|.:.:.
  Fly   355 NVDGS-----PVTNSAKNVKIGFDKSYSYFHEPSPKTRINFEAPVNENGI--ATFNVRLPDSDSR 412

  Rat   441 -LRLLVSAGSLYPAVAKLT--VQAPPSRGPGFLSIEPLDLRSPRVGDTFVLSLRTVGI-PMPTFS 501
             .|:..|.......:..::  ...|.||.|  |.|: ::.:.||:|:.  :|...|.| .:|
  Fly   413 YYRIFASFDGSENTIGSISKFEPTPMSREP--LKIQ-VNTKKPRLGEQ--VSFDVVSIEDLP--- 469

  Rat   502 HYYYMIISRGQIMAMSREPRRALTSISVLVD---------HHLAPSFYFVAYFYHQGLPVANSLL 557
            ::.|.|::||.::            :|..||         ....|:|..|        |.|...:
  Fly   470 YFVYTIVARGNVI------------LSDYVDVPDGQKTYTVKFTPTFSMV--------PKATIYV 514

  Rat   558 INVQPGDCEGKLELKVDGAKEYRN------------GDSMKLQLQTDSEALVALGAVDTALYAVG 610
            ..|...|.:.: |..:|..||:.|            .:.:||:::||:::.|.|..||.::..:
  Fly   515 YYVVNNDLQFE-EKTIDFEKEFSNSIDVSAPTNAKPSEEVKLRIKTDADSFVGLLGVDQSVLLL- 577

  Rat   611 GRSHKPLDMSKVFEVMNSYNL------GCG--PGGGDDALQVFQTAGLAFSDGDRLTQTKENLSC 667
             :|...|....:|..:|.|..      |.|  ||         ||:||       :|.|
  Fly   578 -KSGNDLSQDDIFNSLNIYQTSTPWMNGYGRYPG---------QTSGL-------VTLT------ 619

  Rat   668 PKEKKSRQKRNVNFQKAISEKLGQYSSPDTKRCCQDGMTKLPMARTCEQRAARVPQPACREPFLS 732
                      |.|:         .|::           ..|.|:...|         ..|.|:::
  Fly   620 ----------NANY---------PYNT-----------GPLVMSYVFE---------GSRHPWIT 645

  Rat   733 CCKFAEDLRRNQTRSQAGLARA-QDMLQEEDLIDE--DDILVRSFFPENWLWRVEPVDRSKL-LT 793
            ..::...:|.:.....:.|::: .|...:|.|:.:  ....:|..|||.|.:  |.|...:. ||
  Fly   646 RPRYRVGIRGDSGDRISFLSQSLNDRNLKEILLKQTPQRTTIRKEFPETWFF--ENVGEEEFTLT 708

  Rat   794 VWLPDSLTTWEIHGVSLSKSKGLCVAK-PTRVRVFREFHLHLRLPISVRRFEQLELRPVLYNYLS 857
            ..:||::|:|.:.|.||:.:.|:.:.| |:::|||:.|.:...||.||:|.|.:.:..|::|||.
  Fly   709 KKIPDTITSWVVTGFSLNPTSGIALTKNPSKIRVFQPFFVSTNLPYSVKRGEVIAIPVVIFNYLD 773

  Rat   858 E--DVTVSVHVSPVE-GLCLAGGGLL---------AQQVSVPAGSARPVAFSVVPTAAASIPLKV 910
            :  |..|.:..|..| ....|...:|         .::|::||.|.:.|:|.:.|.......||:
  Fly   774 KTLDADVVMDNSDQEYEFTEATNEVLEKAIDEVRRVKRVTIPANSGKSVSFMIRPKNVGFTTLKI 838

  Rat   911 VARGSFTIGDAVSKILQIEKEGA--IHREEIVYNLDPLNNLGRSLEIPGSSDPN-VIPDGDFSSF 972
            .|..:.. |||:.:.|::|.||.  .....:..||.....:.:||:   :..|| |:|..:|..|
  Fly   839 TATSALA-GDAIHQKLKVEPEGVTLFENRAVFINLKDQPEMSQSLD---ADIPNEVVPQSEFIEF 899

  Rat   973 VRVTASEPLETLGSEGALSP--GGVASLLRLPRGCAEQTMIYLAPTLTASHYLDRTEQWSKLPPE 1035
                     ..:|.  .|.|  ..:.:|:|:|.||.||.|:...|.:....||:.|.:  || |.
  Fly   900 ---------SVVGD--LLGPTLQNLDNLVRMPYGCGEQNMVNFVPNILVLKYLEVTGR--KL-PS 950

  Rat  1036 TKDHAVDLIQKGHMRIQQFRKKDGSFGAWLHRDS--STWLTAFVLKILSLAQEQIGDSPEKLQET 1098
            .:..|...::.|:.|...::..|||:.|:...|:  ||||||:|::....|.......|:.:...
  Fly   951 VESKARKFLEIGYQRELTYKHDDGSYSAFGKSDASGSTWLTAYVMRSFHQAGTYTDIDPKVITAG 1015

  Rat  1099 AGWLLGQQLDDGSFHDPCPVIHRGMQGGLVGTDETVALTAFVVIALHHGLAVFQDENSQQLKKRV 1163
            ..:|:.:|.:.|.|.:...:.....|..|       |||:||::|..        ||.:.:.| .
  Fly  1016 LDFLVSKQKESGEFPEVGKLFDNANQNPL-------ALTSFVLLAFF--------ENHELIPK-Y 1064

  Rat  1164 EASITKANSFLGQKASAGLLGAHASAITAYALTLTKASEDLRNVAHNSLMAMAEETGENLYWGSA 1228
            :::|.||..::.::|.. ....::.||.|.||.|.|..:..:.:|  .|.::|.:..:.::|..|
  Fly  1065 QSAIKKAVRYVAEEADK-TDDQYSLAIAAVALQLAKHPQSEKVIA--KLESVARKENDRMWWSKA 1126

  Rat  1229 ---IGSQDNVVSSTPAPRNPSEPVPQAPALWIETTAYGLLHLLLREGKGEMADKVATWLTHQGSF 1290
               .|....|....|...:            :|.|:|.|| .||.:...|.|..:..||..|.:.
  Fly  1127 TESTGEDGRVFHWKPRSND------------VEITSYVLL-ALLEKDPAEKALPIIKWLISQRNS 1178

  Rat  1291 QGGFRSTQDTVVTLDALSAYWIASHTTEEKALNVTLSSMGRNGYKSHLLQLNNHQVKGLEEELKF 1355
            .|||.||||||:.|.||:.:                      .||:.
  Fly  1179 NGGFSSTQDTVIGLQALTKF----------------------AYKTG------------------ 1203

  Rat  1356 SLGSTINVKV--GGNSKGTLK-------ILRTYNVLDMKNTTCQDLRIEVTVTGYVEYTREANED 1411
            |...|::::.  .|.||.|:|       :|:|:   |:..:|   .:::.|..|    |..|...
  Fly  1204 SGSGTMDIEFSSAGESKNTIKVNPENSLVLQTH---DLPKST---RKVDFTAKG----TGSAMVQ 1258

  Rat  1412 YEYDYDMPAAD-DPSVHSQPV---TPLQL-----------FEGRRSRRRREAPKAADEQESRVQY 1461
            ..|.|::...: .||....|.   ||.||           .|        :|.|..|
  Fly  1259 LSYRYNLAEKEKKPSFKVTPTVKDTPNQLLIVDVCAEYVPLE--------DADKDKD-------- 1307

  Rat  1462 TVCIWRNGNLGLSGMAIADITLLSGFQALRADLEKLTSLSDRYVSHFETDGPH--VLLYFDSV-P 1523
                        |.||:.:|.|.|||......|.|:.:: || |...||....  |::||||: |
  Fly  1308 ------------SNMAVMEIALPSGFVGDSTSLGKIQAV-DR-VKRVETKNSDSTVVVYFDSLTP 1358

  Rat  1524 TTRECVGFGALQEVAVGLVQPASAVLYDYYSPDHKCSVFYAAPTKSKLLSTLCSADVCQ---CAE 1585
            ....|:...|.:..||...:|||..|||||..:.|.:.:|      ::.|:||  |:|:   |.|
  Fly  1359 GDVRCLPLEASKAHAVAKQKPASVSLYDYYDTERKATEYY------QVKSSLC--DICEGADCGE 1415

  Rat  1586 G 1586
            |
  Fly  1416 G 1416

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
C4a	NP_113692.2	A2M_N	139..231	CDD:280081	31/95 (33%)
		A2M_N_2	475..608	CDD:285005	34/154 (22%)
		ANATO	684..752	CDD:237984	7/67 (10%)
		A2M	779..866	CDD:278630	31/90 (34%)
		complement_C3_C4_C5	991..1310	CDD:239226	91/325 (28%)
		A2M_comp	1046..1312	CDD:284982	74/270 (27%)
		A2M_recep	1474..1563	CDD:284981	34/91 (37%)
		NTR_complement_C4	1581..1735	CDD:239639	4/9 (44%)
Tep2	NP_523506.1	A2M_N	115..209	CDD:280081	31/96 (32%)
		A2M_N_2	445..576	CDD:285005	35/157 (22%)
		A2M	694..782	CDD:278630	31/89 (35%)
		A2M_2	909..1198	CDD:239227	90/323 (28%)
		A2M_comp	961..1199	CDD:284982	74/291 (25%)
		A2M_recep	1308..1398	CDD:284981	34/91 (37%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343880
Domainoid	1	1.000	50	1.000	Domainoid score	I11352
eggNOG	1	0.900	-	-		E1_COG2373
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177369at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11412
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.850