DRSC/TRiP Functional Genomics Resources

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Protein Alignment C3 and Tep3

DIOPT Version :9

Sequence 1:NP_058690.2 Gene:C3 / 24232 RGDID:2232 Length:1663 Species:Rattus norvegicus
Sequence 2:NP_523507.2 Gene:Tep3 / 34045 FlyBaseID:FBgn0041181 Length:1469 Species:Drosophila melanogaster


Alignment Length:1618 Identity:370/1618 - (22%)
Similarity:645/1618 - (39%) Gaps:316/1618 - (19%)


- Green bases have known domain annotations that are detailed below.


  Rat    12 LLLLLASSLLALGSP--MYSIITPNVLRLESEETFILEAHDAQGDVPVTVTVQDFLKKQVLTSEK 74
            :|:|:.:.||...|.  :||||.||.||..|:....:..|:|    |.:.|.:..:.....|..|
  Fly    13 VLILVTACLLCQTSAQGLYSIIAPNTLRPNSQFHVAVSLHNA----PESATFKVGILGSSYTDFK 73

  Rat    75 TV-LTGATGHLNRVSIKIPASKEFNADKGHKYVTVVANFGATVVEKAVLVSFQSGY--LFIQTDK 136
            || |...:..|  :..:|||.:.      .:|.......|.........:.|:|..  :.:||||
  Fly    74 TVELRPFSTQL--LHFEIPALRT------DRYRLTAEGLGGVQFTNETQLHFESKQHTVLVQTDK 130

  Rat   137 TIYTPGSTVFYRIFTVDNNLLPV---GKTVVIVIETPDGVPIK--RDILSSHNQY-GILPLSWNI 195
            :||.||..|.||:..:|.||.|.   |:..|.:.::.|.: |:  :||..:::.| ..|.||   
  Fly   131 SIYKPGDLVHYRVLILDANLKPARGYGRVHVDIKDSGDNI-IRSYKDIRLTNSIYSNELRLS--- 191

  Rat   196 PELVNMGQWKIRAFYEHAPKQTFSAEFEVKEYVLPSFEVLVEPTEKFYYIDDPKGLEVSITARFL 260
             :....|.|.|   ......|..:..||:.:::||.|.|.::..:...|.|..  :..::.|.:.
  Fly   192 -DSPRFGTWSI---VVDVSDQEHTQTFEILDHILPKFVVDIDTPKHAIYKDGK--IAATVRAHYA 250

  Rat   261 YGK-------------------------------NVDGTAFVIFGVQDEDKKISLAQSLTRVLIE 294
            :|:                               .:||.|:..|.:::|   :.|.|...|..:.
  Fly   251 FGQPIVGEATLSIYPTFFGSLQPFVNDLITRKVVPIDGNAYFEFDIENE---LHLKQDYERQYLL 312

  Rat   295 DGSGEAVLSRKVLMDGVRPSSPEALVGKSLYVSVTVILHSGSDMVEAERSGIPIVTSPYQIHFTK 359
            |...|                 |...|.....|..:.||                .:.|::...|
  Fly   313 DALVE-----------------EKSTGSVQNYSTVLTLH----------------LNHYRVEAVK 344

  Rat   360 TPKFFKPAMPFDLMVFVTNPDGSPARRV-PVVTQGSDAQALTQDDGVAKLSVNTPNN-------R 416
            .|.::.|.:||:....:...||...|.. |.:|     ..||...|.:::...|..:       :
  Fly   345 VPSYYIPGVPFEATARIARNDGGQLRDFNPQIT-----AYLTNVYGSSEMYNRTAYSLDASGEIK 404

  Rat   417 QPLTITVRTKKEG---IPDARQATRTMQAQPYSTMHNSNNYLHLSVSRVELKPGDNLNVNFHLRT 478
            ...|:.:..:.|.   |.|.:.....:...|...:| |.||:...|.      .|...||..:..
  Fly   405 MKFTVPIGDRDEFHSIIVDYQGVISEVGKIPSKHLH-SKNYITAKVL------NDRPTVNQEISV 462

  Rat   479 DAGQEAKIRYYTYLVMNKGKLLKAGRQVREPGQDLVVLSLPITPEFIPSFRL-----VAYYTLIG 538
            .....|.|:|:.|.|:.:|.::.:......||....:       :|:.||.:     :..||:|.
  Fly   463 VVRSFAPIKYFMYQVVGRGDIILSRNVDVAPGTFHTI-------KFLASFAMMPRANLLVYTVID 520

  Rat   539 ANGQREVVADSVWVDVKDSCVGTLVVKGDPRDNRQPAPGHQTTLRIEGNQGARVGLVAVDKGVFV 603
            .    |.|.|...:.::::.:..:.|....|    ..||....:.|.....:.|||:.||:....
  Fly   521 G----EFVYDEQVIQLEENLLNAVQVDAPIR----APPGQDIDIGISTKPYSYVGLMLVDQNAND 577

  Rat   604 LNKKNKLTQSKIWDVV---EKADIGCTPGSGKNYAGVFMDAGLTF------KTNQGLQTDQREDP 659
            |...:.||..::.|.:   |.:|:....||....:||...:...:      ::|..|..:....|
  Fly   578 LRSGHDLTHKRLMDALRSYELSDVNTPMGSPGKESGVITMSNTDYFIEKEAESNPALDREVSTGP 642

  Rat   660 ECAKPAARRRRSVQLMERRMDKAGQYTDKGLRKCCEDGMRDIPM---KYSCQRRARLITQGESCL 721
            |..|....|:                ||.|.....|  :..:|.   :|                
  Fly   643 EEDKLTTVRK----------------TDIGPAHKIE--VNTLPPGKGRY---------------- 673

  Rat   722 KAFMDCCNYITKLREQHRRDHVLGLARSDVDEDIIPEEDIISRSHFPESWLWTIEELKEPEKNGI 786
             ||    :|..|....:.|.||:   |...|                 :||:.........:|.|
  Fly   674 -AF----SYTPKPFWHNPRVHVM---RDPAD-----------------TWLFLNISASSDGRNSI 713

  Rat   787 STKVMNIFLKDSITTWEILAVSLSDKKGICVADPY-EITVMQDFFIDLRLPYSVVRNEQVEIRAV 850
            ..::     ...:|:|.:.|.:|....|:.::.|. ::...::|:|...||||:.|:|.:.|..|
  Fly   714 HRRI-----PSEMTSWVVSAFALDPVNGLGLSPPNGKLEAYKEFYISTELPYSIKRDELIAIPFV 773

  Rat   851 LFNYREQEKLKVRVELLHN------PAFCSMAT--AKKRYY--QTIEIPPKSSVAVPYVIVPLKI 905
            :.|.|:.: |.|.|...::      |.....||  .|...|  :::::|.:|:.:|.:::.|.::
  Fly   774 VHNNRDSD-LNVEVTFYNSALDFDFPQLDPKATNQPKVELYRRRSLQVPGRSARSVSFIVTPKRV 837

  Rat   906 GLQEVEVKAAVFNHFISDGVKKILKVVPEGM--RVNKTVAVRTLDPEHLGQGGVQREDVPAADLS 968
            |  .:.|||...:....|.|::.|.|...|.  |:|:....      .|......|.:|..|...
  Fly   838 G--PLLVKAMAASSQAGDTVEQNLLVEHPGAMERINRGFLF------ELNSNAQNRRNVTIAVPR 894

  Rat   969 DQVPDTDSETRILLQGTPVAQMAEDAVDGERLKHLIVTPSGCGEQNMIGMTPTVIAVHYLDQTEQ 1033
            :.:|::   |||  :.:.|..:....|.  .|..||:.|:|||||.|:...|.:|.:.||.:..|
  Fly   895 NAIPES---TRI--EVSAVGDLIGSLVG--NLDSLILLPTGCGEQTMVNFVPNLIVLRYLGRLRQ 952

  Rat  1034 WEKFGLEKRQEALELIKKGYTQQLAFKQPSSAYAAF--NNRPPSTWLTAYVVKVFSLAANLIAID 1096
            ...   |....|...:..||.:.|.::..:.|::||  :.:..||||||||.:....||....:|
  Fly   953 LTP---EVELRATNNLAIGYQRILYYRHENGAFSAFGLDIKRSSTWLTAYVARSLRQAAPFTQVD 1014

  Rat  1097 SQVLCGAVKWLILEKQKPDGVFQEDGPVIHQEMIGGFRNTKEADVSLTAFVLIALQEARDICEGQ 1161
            |.||..|:.:| ...|..:|.|:|.|.|        |....:..:||||||.:||.|..|:....
  Fly  1015 SNVLQKALTYL-GSVQSANGGFEERGDV--------FERFGDDGISLTAFVTLALMENVDLYPEY 1070

  Rat  1162 VNSLPGSINKAGEYLEASYLNLQRPYTVAIAGYALALMN-KLEEPYLTKF--LNTAKDRNRW--- 1220
            .|    :||||.:::..........:.:||..|.|:..| ..:..:|.:.  :.|.||..:|   
  Fly  1071 RN----NINKALDFITRGLDGSSNLHAMAIGTYVLSRANHNAKAAFLQRLDSMATNKDGLKWWNK 1131

  Rat  1221 -EEPGQQ---------LYNVEATSYALLALLLLKDFDSVPPVVRWLNEQRYYGGGYGSTQATFMV 1275
             ...|:|         ..|:|.::||.||||.........||:.||.:||...||:.::|.|.:.
  Fly  1132 TAPAGEQQSPWYNATRSVNIEISAYAALALLENNLVGDALPVLNWLMDQRNPKGGFVASQDTVVG 1196

  Rat  1276 FQALAQYQTDVPDHKDLNMDVSLHLPSRSSPTVFRLLWESGSLLRSEETKQN-EGFSLTAKGKGQ 1339
            .|||..:........: |:.:..|. ...:.|:..:..|:...|::.|...| :..|::|.|:|.
  Fly  1197 LQALLMFAERFSSQGN-NLQIGFHY-GEGAETIINVNAENSLALQTVELPNNLKNLSVSATGRGM 1259

  Rat  1340 GTLSVVTVYHAKVKGKATCKKFDLRVTIKPAPETAKKPQDAKSSMI-LDICTRYLGDVD-----A 1398
            ....|...|:..|  .:...:|.|..|:.         :::.:..: |..|..::..|.     :
  Fly  1260 ALAQVSYTYNTNV--TSAWPRFVLDPTVN---------RNSHADYLHLSACASFVSVVGENEQRS 1313

  Rat  1399 TMSILDISMMTGFIPDTNDLELLSSGVDRYISKYEMDKAFSNKNT-LIIYLEKISHSEEDCLSFK 1462
            .|:::::.:.:||:.|.:.|..|.|  ...|.|.|.    .|:|| ::||.:.:.. .|.|.:..
  Fly  1314 NMAVMEVHLPSGFVVDRDTLPTLES--SERIKKVET----QNRNTKVVIYFDYLDR-REVCPTLH 1371

  Rat  1463 VHQFFNVGLIQPGSVKVYSYYNLEESCTRFYHPEKDDGMLSKLCHN----EMCRCAEE 1516
            .::...|...:|.:|.:|.||:......:||...|.:  :..:|.:    ::|..||:
  Fly  1372 AYKTVKVTKHRPVAVVMYDYYDSARRARQFYRAPKSN--ICDICEHANCGDLCEKAEK 1427

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
C3NP_058690.2 A2M_N 129..224 CDD:280081 30/102 (29%)
A2M_N_2 457..603 CDD:285005 31/150 (21%)
ANATO 678..747 CDD:237984 13/71 (18%)
A2M 770..866 CDD:278630 25/96 (26%)
complement_C3_C4_C5 996..1282 CDD:239226 94/303 (31%)
A2M_comp 1051..1282 CDD:284982 77/248 (31%)
A2M_recep 1398..1493 CDD:284981 23/95 (24%)
NTR_complement_C3 1513..1661 CDD:239638 2/4 (50%)
Interaction with CFP/properdin. /evidence=ECO:0000250|UniProtKB:P01024 1634..1659
Tep3NP_523507.2 A2M_N 124..215 CDD:280081 29/98 (30%)
A2M_N_2 448..573 CDD:285005 30/145 (21%)
A2M 697..787 CDD:278630 24/95 (25%)
A2M_2 918..1203 CDD:239227 94/300 (31%)
A2M_comp 967..1200 CDD:284982 75/245 (31%)
A2M_recep 1313..1402 CDD:284981 23/95 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166343887
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2373
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11412
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
54.840

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