DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lrit3 and DIP-delta

DIOPT Version :9

Sequence 1:	NP_001274153.1	Gene:	Lrit3 / 242235	MGIID:	2685267	Length:	681	Species:	Mus musculus
Sequence 2:	NP_001097508.2	Gene:	DIP-delta / 5740816	FlyBaseID:	FBgn0085420	Length:	469	Species:	Drosophila melanogaster

Alignment Length:	394	Identity:	75/394 - (19%)
Similarity:	139/394 - (35%)	Gaps:	120/394 - (30%)

- Green bases have known domain annotations that are detailed below.

Mouse   134 LDLHNNRIASVPNEAVRYLRNLTCL---------------DLSSNRL--------TTLPPDFLDS 175
            |.:|.:.|:.:|..::.|..|...|               .:::|.:        ..:||:.||
  Fly    86 LTIHRHVISRIPRYSITYTDNTWLLHVNQAHQDDRGYYMCQVNTNPMISQVGYLQVVVPPNILD- 149

Mouse   176 WSHLAVTPS--------------RSPDFPPRRIILGLQDNPWFCDCHISK----------VIELS 216
               :..|||              |:..||..:||...:|..   :..:.|          |:.|:
  Fly   150 ---IESTPSSVAVRENQNINMTCRADGFPAPKIIWRREDGE---EIAVEKKKKVLVYDADVLPLT 208

Mouse   217 KVTDHAVVLLDPLMVCSEPERFQGILFQRVELEKCLKPSVMMSATKITSALGSNVLLRCDAKGHP 281
            ||:.:.:    ...:|.........:.:|:.|:....|.:.:....:.:..|::|.:.|..:.||
  Fly   209 KVSRNEM----GAYLCIATNGVPPSVSKRIILDVEFSPMIWVPNQLVGAPSGTDVTIDCHTEAHP 269

Mouse   282 TPQLTWTRSDGSTVNYTVIQESPGEGIRWSI----------ISLTSISHKDAGDYRCKAKNLAGI 336
            ...:.|.        |..:...|.:..:...          :::.::.:.|.|:|||.:||..|.
  Fly   270 KAIIYWV--------YNSVMVLPSKKYKTDYTENSYRAHMKLTIRNLQYGDFGNYRCISKNSLGE 326

Mouse   337 SEAVVTVTVVGGVTTTLSPDSSERSPGEPPEQHPQPGLGGSTPPS---------KSWLSPGLTSA 392
            :|..:.|..: .:.:|.|...:..:. |..|.:..|.....|..|         |:.|.||..|:
  Fly   327 TEGSIRVYEI-PLPSTPSKQVTHTTV-ESRENNIIPSSRNDTTKSLQTDVGYAMKNDLYPGSASS 389

Mouse   393 PSYPTPSAALYTSTWSPPPSSLPPIFSAASATTSVQTSISGRTARTSHQPPLLHPGGKSNAKIEK 457
            .|....|                   ||||:::|:|||..              |||.:...:..
  Fly   390 SSSGGSS-------------------SAASSSSSMQTSAL--------------PGGVAGNSLSS 421

Mouse   458 NGRK 461
            .|.|
  Fly   422 MGSK 425

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lrit3	NP_001274153.1	LRR 1. /evidence=ECO:0000255	56..79
		LRR_8	61..117	CDD:290566
		LRR 2. /evidence=ECO:0000255	80..103
		leucine-rich repeat	83..106	CDD:275378
		LRR 3. /evidence=ECO:0000255	104..128
		LRR_8	105..165	CDD:290566	8/45 (18%)
		LRR_4	106..146	CDD:289563	3/11 (27%)
		leucine-rich repeat	107..130	CDD:275378
		LRR_4	129..170	CDD:289563	8/58 (14%)
		LRR 4. /evidence=ECO:0000255	129..151		4/16 (25%)
		leucine-rich repeat	131..154	CDD:275378	5/19 (26%)
		LRR 5. /evidence=ECO:0000255	152..175		6/45 (13%)
		leucine-rich repeat	155..168	CDD:275378	2/35 (6%)
		Ig	254..335	CDD:299845	16/90 (18%)
		IG_like	263..339	CDD:214653	16/85 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	350..391		11/49 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	425..464		9/37 (24%)
		FN3	489..563	CDD:238020
DIP-delta	NP_001097508.2	IG	51..143	CDD:214652	8/56 (14%)
		Ig	145..238	CDD:416386	20/103 (19%)
		Ig strand A	145..149	CDD:409353	1/3 (33%)
		Ig strand A'	154..159	CDD:409353	2/4 (50%)
		Ig strand B	165..172	CDD:409353	1/6 (17%)
		Ig strand C	178..183	CDD:409353	2/4 (50%)
		Ig strand C'	185..187	CDD:409353	1/1 (100%)
		Ig strand D	195..199	CDD:409353	0/3 (0%)
		Ig strand E	203..209	CDD:409353	2/5 (40%)
		Ig strand F	216..223	CDD:409353	1/6 (17%)
		Ig strand G	230..238	CDD:409353	2/7 (29%)
		Ig	242..333	CDD:416386	18/98 (18%)
		Ig strand A'	250..253	CDD:409353	0/2 (0%)
		Ig strand B	259..266	CDD:409353	2/6 (33%)
		Ig strand C	272..277	CDD:409353	1/12 (8%)
		Ig strand C'	281..283	CDD:409353	0/1 (0%)
		Ig strand D	289..293	CDD:409353	0/3 (0%)
		Ig strand E	295..305	CDD:409353	0/9 (0%)
		Ig strand F	314..322	CDD:409353	4/7 (57%)
		Ig strand G	325..334	CDD:409353	2/8 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900