DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Atp4b and GABA-B-R1

DIOPT Version :9

Sequence 1:	NP_036642.2	Gene:	Atp4b / 24217	RGDID:	2178	Length:	294	Species:	Rattus norvegicus
Sequence 2:	NP_001246033.1	Gene:	GABA-B-R1 / 34878	FlyBaseID:	FBgn0260446	Length:	841	Species:	Drosophila melanogaster

Alignment Length:	193	Identity:	39/193 - (20%)
Similarity:	72/193 - (37%)	Gaps:	37/193 - (19%)

- Green bases have known domain annotations that are detailed below.

  Rat    48 YVVMTGLFALCIYVLM--QTIDP---YTPDYQDQLKSP-----GVTLRPDVYGERGLQISYNISE 102
            |.:::||.::.:.:|:  |..||   |...:  .|:.|     .:.:||::.       ......
  Fly   582 YTMVSGLLSIDLVILLSWQIFDPLQRYLETF--PLEDPVSTTDDIKIRPELE-------HCESQR 637

  Rat   103 NSSWAGLTHTLHS-------FLAGYTPASQQDSINCSSEKYFFQETFSAPNHTKFSCKFTADMLQ 160
            ||.|.||.:....       |||..|.:.:...||.|  :|.....:    :....|..||.:..
  Fly   638 NSMWLGLVYGFKGLILVFGLFLAYETRSIKVKQINDS--RYVGMSIY----NVVVLCLITAPVGM 696

  Rat   161 NCSGLVDPSFGFEEGKPCFIIKMNRIVKFLPS-----NNTAPRVDCTFQDDPQKPRKDIEPLQ 218
            ..:...|.||.|......|...::.::.|:|.     .:...:.:..:..|....::|.|..|
  Fly   697 VIASQQDASFAFVALAVIFCCFLSMLLIFVPKVIEVIRHPKDKAESKYNPDSAISKEDEERYQ 759

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atp4b	NP_036642.2	Na_K_ATPase_bet	2..294	CDD:273446	39/193 (20%)
Atp4b	NP_036642.2	immunoglobulin-like. /evidence=ECO:0000250	194..294		4/25 (16%)
GABA-B-R1	NP_001246033.1	PBP1_GABAb_receptor	34..437	CDD:107361
		ANF_receptor	52..415	CDD:279440
		7tm_3	476..730	CDD:278433	35/162 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3927
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900