Protein Alignment Atp1a1 and Atpalpha

DIOPT Version :10

• Sequence 1: NP_036636.1
• Gene: Atp1a1 / 24211
• RGDID: 2167
• Length: 1023
• Species: Rattus norvegicus
• Sequence 2: NP_732572.1
• Gene: Atpalpha / 48971
• FlyBaseID: FBgn0002921
• Length: 1041
• Species: Drosophila melanogaster
• Alignment Length: 1032
• Identity: 766/1032 - (74%)
• Similarity: 893/1032 - (86%)
• Gaps: 14/1032 - (1%)

  Rat     6 GR-DKYEPAAV--------SEHGDKKSK-----KAKKERDMDELKKEVSMDDHKLSLDELHRKYG 56
            || |.|..|.|        :..|..||:     |..|:.::|:||:|:.:|.||:|.:||::::.
  Fly    10 GRADSYRVATVIATDDDNRTADGQYKSRRKMPAKVNKKENLDDLKQELDIDFHKISPEELYQRFQ 74

  Rat    57 TDLSRGLTPARAAEILARDGPNALTPPPTTPEWVKFCRQLFGGFSMLLWIGAILCFLAYGIRSAT 121
            |....||:.|:|.|.|.||||||||||..||||||||:.|||||:|||||||||||:||.|:::|
  Fly    75 THPENGLSHAKAKENLERDGPNALTPPKQTPEWVKFCKNLFGGFAMLLWIGAILCFVAYSIQAST 139

  Rat   122 EEEPPNDDLYLGVVLSAVVIITGCFSYYQEAKSSKIMESFKNMVPQQALVIRNGEKMSINAEDVV 186
            .|||.:|:||||:|||||||:||.||||||:|||||||||||||||.|.|||.|||:::.|||:|
  Fly   140 SEEPADDNLYLGIVLSAVVIVTGIFSYYQESKSSKIMESFKNMVPQFATVIREGEKLTLRAEDLV 204

  Rat   187 VGDLVEVKGGDRIPADLRIISANGCKVDNSSLTGESEPQTRSPDFTNENPLETRNIAFFSTNCVE 251
            :||:||||.|||||||:|||.|...||||||||||||||:|..:||:||||||:|:||||||.||
  Fly   205 LGDVVEVKFGDRIPADIRIIEARNFKVDNSSLTGESEPQSRGAEFTHENPLETKNLAFFSTNAVE 269

  Rat   252 GTARGIVVYTGDRTVMGRIATLASGLEGGQTPIAEEIEHFIHLITGVAVFLGVSFFILSLILEYT 316
            |||:|:|:..||.|||||||.|||||:.|:||||:||.|||||||||||||||:||:::.||.|.
  Fly   270 GTAKGVVISCGDHTVMGRIAGLASGLDTGETPIAKEIHHFIHLITGVAVFLGVTFFVIAFILGYH 334

  Rat   317 WLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTL 381
            ||:|||||||||||||||||||||||||||||||||.||||||||||||||||||||||||||||
  Fly   335 WLDAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMASKNCLVKNLEAVETLGSTSTICSDKTGTL 399

  Rat   382 TQNRMTVAHMWFDNQIHEADTTENQSGVSFDKTSATWFALSRIAGLCNRAVFQANQENLPILKRA 446
            ||||||||||||||||.||||||:||||.:|:||..:.||||||.|||||.|:..|:.:||||:.
  Fly   400 TQNRMTVAHMWFDNQIIEADTTEDQSGVQYDRTSPGFKALSRIATLCNRAEFKGGQDGVPILKKE 464

  Rat   447 VAGDASESALLKCIEVCCGSVMEMREKYTKIVEIPFNSTNKYQLSIHKNPNASEPKHLLVMKGAP 511
            |:|||||:|||||:|:..|.||.:|::..||.|:|||||||||:|||:..:.::|::||||||||
  Fly   465 VSGDASEAALLKCMELALGDVMNIRKRNKKIAEVPFNSTNKYQVSIHETEDTNDPRYLLVMKGAP 529

  Rat   512 ERILDRCSSILLHGKEQPLDEELKDAFQNAYLELGGLGERVLGFCHLLLPDEQFPEGFQFDTDEV 576
            ||||:|||:|.::|||:.||||:|:||.|||:|||||||||||||..:||.:::|.||:|:||::
  Fly   530 ERILERCSTIFINGKEKVLDEEMKEAFNNAYMELGGLGERVLGFCDFMLPSDKYPNGFKFNTDDI 594

  Rat   577 NFPVDNLCFVGLISMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETV 641
            |||:|||.||||:||||||||||||||.|||||||||||||||||||||||||.|||||||||||
  Fly   595 NFPIDNLRFVGLMSMIDPPRAAVPDAVAKCRSAGIKVIMVTGDHPITAKAIAKSVGIISEGNETV 659

  Rat   642 EDIAARLNIPVNQVNPRDAKACVVHGSDLKDMTSEELDDILRYHTEIVFARTSPQQKLIIVEGCQ 706
            ||||.||||||::||||:|||.||||::|:|::|::||:||||||||||||||||||||||||||
  Fly   660 EDIAQRLNIPVSEVNPREAKAAVVHGAELRDVSSDQLDEILRYHTEIVFARTSPQQKLIIVEGCQ 724

  Rat   707 RQGAIVAVTGDGVNDSPALKKADIGVAMGIVGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDN 771
            |.||||||||||||||||||||||||||||.||||||||||||||||||||||||||||||||||
  Fly   725 RMGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDN 789

  Rat   772 LKKSIAYTLTSNIPEITPFLIFIIANIPLPLGTVTILCIDLGTDMVPAISLAYEQAESDIMKRQP 836
            ||||||||||||||||:|||.||:.:||||||||||||||||||||||||||||.||:|||||.|
  Fly   790 LKKSIAYTLTSNIPEISPFLAFILCDIPLPLGTVTILCIDLGTDMVPAISLAYEHAEADIMKRPP 854

  Rat   837 RNPKTDKLVNERLISMAYGQIGMIQALGGFFTYFVILAENGFLPFHLLGIRETWDDRWINDVEDS 901
            |:|..|||||.|||||||||||||||..|||.||||:|||||||..|.|||:.||.:.:||:.||
  Fly   855 RDPFNDKLVNSRLISMAYGQIGMIQAAAGFFVYFVIMAENGFLPKKLFGIRKMWDSKAVNDLTDS 919

  Rat   902 YGQQWTYEQRKIVEFTCHTAFFVSIVVVQWADLVICKTRRNSVFQQGMKNKILIFGLFEETALAA 966
            |||:|||..||.:|:|||||||:||||||||||:||||||||:|||||:|..|.|||..||.|||
  Fly   920 YGQEWTYRDRKTLEYTCHTAFFISIVVVQWADLIICKTRRNSIFQQGMRNWALNFGLVFETVLAA 984

  Rat   967 FLSYCPGMGAALRMYPLKPTWWFCAFPYSLLIFVYDEVRKLIIRRRPGGWVEKETYY 1023
            ||||||||...|||||||..|||.|.|::|.||:|||.|:..:||.||||:|:||||
  Fly   985 FLSYCPGMEKGLRMYPLKLVWWFPAIPFALAIFIYDETRRFYLRRNPGGWLEQETYY 1041

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Atp1a1	NP_036636.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..38		14/45 (31%)
		ATPase-IIC_X-K	29..1023	CDD:273445	753/993 (76%)
		Phosphoinositide-3 kinase binding	82..84		1/1 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	216..235		13/18 (72%)
		Mediates interaction with SCN7A. /evidence=ECO:0000250|UniProtKB:Q8VDN2	596..717		104/120 (87%)
Atpalpha	NP_732572.1	ATPase-IIC_X-K	45..1041	CDD:273445	754/995 (76%)