DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Adrb2 and Octbeta1R

DIOPT Version :9

Sequence 1:	NP_036624.2	Gene:	Adrb2 / 24176	RGDID:	2060	Length:	418	Species:	Rattus norvegicus
Sequence 2:	NP_001262843.1	Gene:	Octbeta1R / 42652	FlyBaseID:	FBgn0038980	Length:	508	Species:	Drosophila melanogaster

Alignment Length:	393	Identity:	139/393 - (35%)
Similarity:	204/393 - (51%)	Gaps:	39/393 - (9%)

- Green bases have known domain annotations that are detailed below.

  Rat    31 AWVVGMAILMSVIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGASHIL 95
            |.|.....::..|:||.:.||:|||.::.:..:|:.:||||:.|||.||:::.|..:.|.||.::
  Fly   105 ALVFVKCFIIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMI 169

  Rat    96 MKMWNFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYVAITSPFKYQSLLTKNKARVVILMVWIV 160
            ...|.||:..|:.|.|.||...||||..||.|:||||.||..|..|..::|:.:..:::||||:.
  Fly   170 SGKWMFGSVMCDMWNSFDVYFSTASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLS 234

  Rat   161 SGLTSFLPIQMHWYRATHKQAIDCYAKET--CCDFFTNQAYAIASSIVSFYVPLVVMVFVYSRVF 223
            ..|.|||||...||..|....   |.|..  .|:|..|:||||.||.:||::|.:||:.:|.|::
  Fly   235 PALLSFLPICSGWYTTTENYK---YLKSNPHICEFKVNKAYAIVSSSMSFWIPGIVMLSMYYRIY 296

  Rat   224 QVAKRQLQKIDKSEG-----RFHAQNLSQVEQDGRSGHGLRRSSKFCLKEHKALKTLGIIMGTFT 283
            |.|.||.:.:.:|:.     ..|.| :||:.:...|....:.:.....:|.||.:||||||..|.
  Fly   297 QEADRQERLVYRSKVAALLLEKHLQ-ISQIPKPRPSIQVEQSTISTMRRERKAARTLGIIMSAFL 360

  Rat   284 LCWLPFFIVNIVHVIRANLI-PKEVYILLNWLGYVNSAFNPLIYCR-SPDFRIAFQELLCLRRSS 346
            :||||||:..||..:..:.| |:.:..:|.|:||.|||.||:||.. :.|||.||::.|    .|
  Fly   361 ICWLPFFLWYIVSSLCDSCITPRLLVGILFWIGYFNSALNPIIYAYFNRDFRAAFKKTL----KS 421

  Rat   347 SKTYGNGYSSNSNGRTD----------YTGEQSAYQLGQEKENELLCEEAPGMEGFVNCQGTVPS 401
            ...|...:.....||.|          ..|...|.:.|.            |.....||..:..|
  Fly   422 LFPYAFYFCRRGRGRDDDRDLEFGGPSRRGTNGAQRTGS------------GSAEMANCVNSTAS 474

  Rat   402 LSI 404
            ..|
  Fly   475 SEI 477

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Adrb2	NP_036624.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23
		7tm_4	48..340	CDD:304433	120/300 (40%)
		7tm_1	50..326	CDD:278431	113/283 (40%)
		PDZ-binding	415..418
Octbeta1R	NP_001262843.1	7tm_4	112..>231	CDD:304433	47/118 (40%)
Octbeta1R	NP_001262843.1	7tm_1	124..404	CDD:278431	113/283 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	230	1.000	Domainoid score	I2359
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm44908
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24248
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X822
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	6.010