DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ada and Adgf-E

DIOPT Version :9

Sequence 1:	NP_569083.1	Gene:	Ada / 24165	RGDID:	2031	Length:	352	Species:	Rattus norvegicus
Sequence 2:	NP_610977.1	Gene:	Adgf-E / 36627	FlyBaseID:	FBgn0033952	Length:	539	Species:	Drosophila melanogaster

Alignment Length:	335	Identity:	85/335 - (25%)
Similarity:	139/335 - (41%)	Gaps:	71/335 - (21%)

- Green bases have known domain annotations that are detailed below.

  Rat    47 RNIIGMDKPLSLPDFLAKF-----DYYMPAIAGCREAIKRIAYEFVEMKAKEGVVYVEVR-YSPH 105
            |:::|:   ..|.|.|.::     |||..|:.           ||.    .:||.|:||| ..|.
  Fly   226 RHMMGI---FGLLDGLLQYAPVWGDYYYNALK-----------EFY----ADGVQYLEVRSVLPQ 272

  Rat   106 LLANSKVDPIPWNQAEGDLTPD-EVVDLVNQGLQ--EGEQAFGIKVRSILCCMRH-QPSWSPEVL 166
            |.:           .:|...|. |.|.:....|:  :.|....|..:.|...:|| ||....|.:
  Fly   273 LYS-----------LDGSRMPKRETVQIYKDTLERFKKEHPGFIDSKLIYAPIRHVQPELVGEYI 326

  Rat   167 ELCKKYHQK---TVVAMDLAGDETIEGSSLFPGHVEAYEGA----VKDGIHRTVHAGEVG--SAE 222
            :.|.:.:::   .||..||.|.|.:       ||..:...|    :.|.||...|||:..  .:.
  Fly   327 KECTELNKEFPSFVVGFDLVGQEDV-------GHPLSNFAAELLKLPDHIHFYFHAGQTNWYGSH 384

  Rat   223 VVREAVD--ILKTERVGHGYHTIEDEALYNRLLKE-NMHFEVCPWSSYLTGAWNPKTTHAVVRFK 284
            |.:..:|  :|.|:|:|||| ||....:..||.|. |:..||||.|:.:....:...:|......
  Fly   385 VDQNLLDAIVLGTKRIGHGY-TITKHPVLMRLAKYLNIALEVCPVSNQVLQLGSDYRSHPAATLI 448

  Rat   285 DDQANYSLNSDDPLIFKST-VDTDYQM-------VKKDMGFTEEEFKRLNINAAKSSFLPEDEKK 341
            .:.....:.|..|..:::. :..|:.|       :..|:.|    .||...|:.|.|.|.::.|.
  Fly   449 AENVPMVIASGSPGFWRAAPLSHDFYMAFLGIAPMNADLKF----LKRTAKNSIKYSSLKDEAKA 509

  Rat   342 ELLERLYKEY 351
            |.:|:..|::
  Fly   510 EAMEKWKKQW 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ada	NP_569083.1	metallo-dependent_hydrolases	9..347	CDD:294200	84/329 (26%)
Adgf-E	NP_610977.1	A_deaminase_N	46..125	CDD:285627
		adm_rel	52..527	CDD:273620	85/335 (25%)
		ADGF	105..519	CDD:238646	85/333 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1816
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810