DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Slc5a12 and CG32669

DIOPT Version :9

Sequence 1:	NP_001003915.1	Gene:	Slc5a12 / 241612	MGIID:	2138890	Length:	623	Species:	Mus musculus
Sequence 2:	NP_727460.1	Gene:	CG32669 / 326229	FlyBaseID:	FBgn0052669	Length:	604	Species:	Drosophila melanogaster

Alignment Length:	561	Identity:	205/561 - (36%)
Similarity:	317/561 - (56%)	Gaps:	41/561 - (7%)

- Green bases have known domain annotations that are detailed below.

Mouse     8 AWDYVVFAGLFVISSGIGVFFAIKERKKTTSREFLVGGRQMSFGPVALSLTASFMSAVTVLGTPA 72
            ||||.:.|.:.:||..||:::.....|::|:.|:|:..|.|:..|||.||.||||||||:||...
  Fly     6 AWDYTILAVVLIISVAIGIYYRFVGGKQSTTTEYLLADRSMNVAPVAFSLMASFMSAVTILGVSM 70

Mouse    73 EVYRFGASFFLFLISYVFVVFFTSELFLPVFYRSGITSTYEYLQLRFNKPVRYAATIIYIVQTIL 137
            |.|::|..|.:..:|||......:.|.:|||||....|.||||:|||....|.||::.:.:|.:|
  Fly    71 ENYQYGTMFVVINLSYVLSTPVAAYLIIPVFYRLKTASVYEYLELRFGYATRLAASLSFSLQMVL 135

Mouse   138 YTGVVVYAPALALNQVTGFNLWASVFATGIVCTFYCSLGGLKAVVWTDAFQMVVMIVGFLTVLIQ 202
            |.|:|||||||||..|||.:...|:...|:|||||.:|||:|||:.||.:|.::|.....:|:|.
  Fly   136 YMGIVVYAPALALEAVTGLSQVFSIVIVGVVCTFYATLGGMKAVLITDIYQSLLMFAAVFSVIIC 200

Mouse   203 GSNHVGGFNNVLEKAGNGSRLHIVDFDVDPLRRHTFWTITIGGTFTWLGVYGVNQSTIQRCISCK 267
            .....|....:...|....|:::.:|.|||..|||::|..:||..|:|.:|||||:.:||.::.|
  Fly   201 AWVKAGSLEVIWRVAQENGRINLTNFSVDPTERHTWFTQILGGCATYLAIYGVNQTQVQRLMAVK 265

Mouse   268 TEKHAKLALYFNLLGLWIIVACAVFSGLIMYSHFKDCDPWTSGVISAPDQLMPYFVMEIFATMPG 332
            :...|:.||::.|..|.::.....||||.:|.:::||||...|.:::.||:||.||::......|
  Fly   266 SLSAARAALWWCLPILCLLSLSTCFSGLCIYWYYRDCDPLLEGRVNSRDQVMPLFVVDTMGEYTG 330

Mouse   333 LPGLFVACAFSGTLSTVAASINALATVTFEDFVK---SCFPH--LSDKLSTWISKGLCILFGIMC 392
            |.||||:..|..:|||:::.|::||.||.||::|   ||...  |:|:.:.|.||.|.:.||.:|
  Fly   331 LAGLFVSGIFCASLSTISSIISSLAAVTLEDYLKPLVSCCAKRTLTDRQTLWYSKLLSLFFGALC 395

Mouse   393 TSMAVVASLMGSVVQAP----GIVSQERAITGSFQRNLASVCYGVSIWKL-IMGALGGLLTGITL 452
            ..||.:|..:|.::||.    ||:.  ..:.|.|       ..|:.:.|. ..||:||||..:..
  Fly   396 IGMAFMAGSIGGLLQAALSIFGIIG--GPLLGLF-------TLGMYVTKANEKGAIGGLLISLAF 451

Mouse   453 SFWVAIGSFIYPAPESKTLPLPLSTEHCVELNITTTVAPQISSRPVLADT-------WYSLSYLY 510
            .||:..|.     |:...:.|.:||..|   .:..:.|..|..:.|:|..       .|.:||::
  Fly   452 CFWIGFGQ-----PKPPLVSLDMSTAGC---PVDRSFARDIFLKTVIAVAEEEHYFYLYRISYMW 508

Mouse   511 FSAVGCLGCIAAGIIISFL-------TGKQRGKDIDPLLIR 544
            ::|:|.|.....|.::|:|       ..::..:|.|..||:
  Fly   509 YAALGFLITFFGGWLLSWLFALLKWDNNRRIYQDADCTLIK 549

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Slc5a12	NP_001003915.1	SLC5-6-like_sbd	3..531	CDD:294310	201/546 (37%)
CG32669	NP_727460.1	SLC5sbd_NIS-SMVT	7..527	CDD:271383	199/536 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	366	1.000	Domainoid score	I922
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	431	1.000	Inparanoid score	I1711
Isobase	1	0.950	-	0	Normalized mean entropy	S4392
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000151
OrthoInspector	1	1.000	-	-		mtm8902
orthoMCL	1	0.900	-	-		OOG6_101204
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6277
SonicParanoid	1	1.000	-	-		X112
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.740