DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Acadm and Mcad

DIOPT Version :9

Sequence 1:	NP_058682.2	Gene:	Acadm / 24158	RGDID:	2012	Length:	421	Species:	Rattus norvegicus
Sequence 2:	NP_648149.1	Gene:	Mcad / 38864	FlyBaseID:	FBgn0035811	Length:	419	Species:	Drosophila melanogaster

Alignment Length:	419	Identity:	291/419 - (69%)
Similarity:	337/419 - (80%)	Gaps:	11/419 - (2%)

- Green bases have known domain annotations that are detailed below.

  Rat     2 AAALRRGYKVLRSVSHFECRAQHTKPSLKQEPGLGFSFELTEQQKEFQTIARKFAREEIIPVAPD 66
            |.|||:    |.|.|.......|..|:       |.||.|||.|.:.|.:||||.||||||||..
  Fly     9 APALRQ----LVSQSRAYAAVSHVSPN-------GTSFALTEDQLQLQELARKFTREEIIPVAAQ 62

  Rat    67 YDKSGEYPFPLIKRAWELGLINTHIPESCGGLGLGTFDACLITEELAYGCTGVQTAIEANSLGQM 131
            ||||||||:|:||:||||||:|.|||...|||.|..|..||..|||||||||:.||:||:.|||.
  Fly    63 YDKSGEYPWPIIKKAWELGLMNNHIPADIGGLDLDVFTTCLSAEELAYGCTGIMTALEASGLGQT 127

  Rat   132 PVIIAGNDQQKKKYLGRMTEQLMMCAYCVTEPSAGSDVAGIKTKAEKKGDEYVINGQKMWITNGG 196
            |||::||.:||||||||:.|:.::.|||||||.|||||:||||:|||||||:|||||||||||||
  Fly   128 PVILSGNKEQKKKYLGRLLEEPLVAAYCVTEPGAGSDVSGIKTRAEKKGDEWVINGQKMWITNGG 192

  Rat   197 KANWYFVLTRSNPDPKVPASKAFTGFIVEADTPGIHIGKKELNMGQRCSDTRGITFEDVRVPKEN 261
            .|||||||.|:|||||.|.||||||||||.|:||:..|:||||||||.|||||||||||||||||
  Fly   193 VANWYFVLARTNPDPKCPPSKAFTGFIVERDSPGLTPGRKELNMGQRASDTRGITFEDVRVPKEN 257

  Rat   262 VLIGEGAGFKIAMGAFDRTRPTVAAGAVGLAQRALDEATKYALDRKTFGKLLVEHQGVSFLLAEM 326
            ||||||||||||||.||:|||.|||||||||||.||||.||||:|||||..:..||.|.|:||:|
  Fly   258 VLIGEGAGFKIAMGTFDKTRPPVAAGAVGLAQRCLDEALKYALERKTFGVPIAYHQAVQFMLADM 322

  Rat   327 AMKVELARLSYQRAAWEVDSGRRNTYFASIAKAFAGDIANQLATDAVQIFGGYGFNTEYPVEKLM 391
            |:.||.:||:::.:|||:|.||||:|:|||||..|.|:||::|:||||||||.|||:||||||||
  Fly   323 AIGVETSRLAWRLSAWEIDQGRRNSYYASIAKCHAADMANKIASDAVQIFGGNGFNSEYPVEKLM 387

  Rat   392 RDAKIYQIYEGTAQIQRLIIAREHIEKYK 420
            ||||||||||||:|||||||:|...|..|
  Fly   388 RDAKIYQIYEGTSQIQRLIISRNMYEAAK 416

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Acadm	NP_058682.2	CaiA	39..420	CDD:224871	279/380 (73%)
		MCAD	41..418	CDD:173846	277/376 (74%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:P41367	278..281		1/2 (50%)
Mcad	NP_648149.1	CaiA	35..411	CDD:224871	278/375 (74%)
Mcad	NP_648149.1	MCAD	37..414	CDD:173846	277/376 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	222	1.000	Domainoid score	I2514
eggNOG	1	0.900	-	-		E1_COG1960
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3
Inparanoid	1	1.050	586	1.000	Inparanoid score	I964
OMA	1	1.010	-	-		QHG56625
OrthoDB	1	1.010	-	-		D281661at33208
OrthoFinder	1	1.000	-	-		FOG0005377
OrthoInspector	1	1.000	-	-		oto98245
orthoMCL	1	0.900	-	-		OOG6_101120
Panther	1	1.100	-	-	LDO	PTHR48083
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3813
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.840