Protein Alignment FTSJ1 and R74.7

DIOPT Version :10

• Sequence 1: NP_001428126.1
• Gene: FTSJ1 / 24140
• HGNCID: 13254
• Length: 337
• Species: Homo sapiens
• Sequence 2: NP_497843.1
• Gene: R74.7 / 175543
• WormBaseID: WBGene00011281
• Length: 337
• Species: Caenorhabditis elegans
• Alignment Length: 304
• Identity: 168/304 - (55%)
• Similarity: 217/304 - (71%)
• Gaps: 25/304 - (8%)

Human     1 MGRTSKDKRDVYYRLAKENGWRARSAFKLLQLDKEFQLFQGVTRAVDLCAAPGSWSQVLSQKIGG 65
            ||:||:||||:||||||||.|||||||||:|:|.|||:.:||.|||||||||||||||||:::..
 Worm     1 MGKTSRDKRDIYYRLAKENKWRARSAFKLMQIDDEFQILKGVRRAVDLCAAPGSWSQVLSKRLYE 65

Human    66 QG-SGHVVAVDLQAMAPLPGVVQIQGDITQLSTAKEIIQHFKGCPADLVVCDGAPDVTGLHDVDE 129
            :. ...:||:|||.|||:|||:|:|||||.:.||.::|:||.|..:|:|:|||||||||:|.:||
 Worm    66 EDQEAKIVAIDLQPMAPIPGVIQLQGDITSVDTANQVIKHFSGEKSDIVICDGAPDVTGIHSLDE 130

Human   130 YMQAQLLLAALNIATHVLKPGGCFVAKIFRGRDVTLLYSQLQVFFSSVLCAKPRSSRNSSIEAFA 194
            :|||:|:|||.||.:||||.||.|:|||||.|:.:|||:|::.:|..|..|||||||.||.|||.
 Worm   131 FMQAELILAAFNITSHVLKEGGNFLAKIFRSRNSSLLYAQMKKYFKKVYLAKPRSSRQSSCEAFV 195

Human   195 VCQGYDPPEGFIPDLSKPLLD----HSYDPDFNQLDGPTRIIVPFVTCGDLSSYDSDRSYPLDL- 254
            :|..|.|||||:|.:.|..||    .:..||.  :||       ||||||||.:||::|||||:
 Worm   196 LCLDYSPPEGFVPTMGKTSLDATDASAISPDI--IDG-------FVTCGDLSGWDSEKSYPLDID 251

Human   255 ----------EGGSEYKYTPPTQPPISPPYQEACTLKRKGQLAK 288
                      |....|::....|||..|.|:.|...|:.|..||
 Worm   252 ACFPKGEIDEEQKKRYEFKDVVQPPTDPAYKAALDKKKSGVFAK 295

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FTSJ1	NP_001428126.1	Required for binding to WDR6. /evidence=ECO:0000269|PubMed:32558197	221..240		7/18 (39%)
R74.7	NP_497843.1	RlmE	6..200	CDD:440062	123/193 (64%)