DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KIF4A and Kif4a

DIOPT Version :9

Sequence 1:	NP_036442.3	Gene:	KIF4A / 24137	HGNCID:	13339	Length:	1232	Species:	Homo sapiens
Sequence 2:	XP_006257175.1	Gene:	Kif4a / 84393	RGDID:	620526	Length:	1231	Species:	Rattus norvegicus

Alignment Length:	1234	Identity:	1068/1234 - (86%)
Similarity:	1142/1234 - (92%)	Gaps:	5/1234 - (0%)

- Green bases have known domain annotations that are detailed below.

Human     1 MKEEVKGIPVRVALRCRPLVPKEISEGCQMCLSFVPGEPQVVVGTDKSFTYDFVFDPSTEQEEVF 65
            ||||||||||||||||||||.|||:||||.|||||||||||||||||||||||||||||||||||
  Rat     1 MKEEVKGIPVRVALRCRPLVSKEINEGCQTCLSFVPGEPQVVVGTDKSFTYDFVFDPSTEQEEVF 65

Human    66 NTAVAPLIKGVFKGYNATVLAYGQTGSGKTYSMGGAYTAEQENEPTVGVIPRVIQLLFKEIDKKS 130
            ||||||||||||||||||||||||||||||||||||||||||::..:||||||||||||||:||:
  Rat    66 NTAVAPLIKGVFKGYNATVLAYGQTGSGKTYSMGGAYTAEQEHDSAIGVIPRVIQLLFKEINKKT 130

Human   131 DFEFTLKVSYLEIYNEEILDLLCPSREKA-QINIREDPKEGIKIVGLTEKTVLVALDTVSCLEQG 194
            |||||||||||||||||||||||.||||| |||||||||||||||||||||||||.|||||||||
  Rat   131 DFEFTLKVSYLEIYNEEILDLLCSSREKASQINIREDPKEGIKIVGLTEKTVLVASDTVSCLEQG 195

Human   195 NNSRTVASTAMNSQSSRSHAIFTISLEQRKKSDKNSSFRSKLHLVDLAGSERQKKTKAEGDRLKE 259
            ||.||||||||||||||||||||||:|||||:|||||||||||||||||||||||||||||||||
  Rat   196 NNCRTVASTAMNSQSSRSHAIFTISIEQRKKNDKNSSFRSKLHLVDLAGSERQKKTKAEGDRLKE 260

Human   260 GININRGLLCLGNVISALGDDKKGGFVPYRDSKLTRLLQDSLGGNSHTLMIACVSPADSNLEETL 324
            ||||||||||||||||||||||||.||||||||||||||||||||||||||||||||||||||||
  Rat   261 GININRGLLCLGNVISALGDDKKGNFVPYRDSKLTRLLQDSLGGNSHTLMIACVSPADSNLEETL 325

Human   325 NTLRYADRARKIKNKPIVNIDPQTAELNHLKQQVQQLQVLLLQAHGGTLPGSITVEPSENLQSLM 389
            |||||||||||||||||:|||||.|||||||||||||||||||||||||||:|.|:|||||||||
  Rat   326 NTLRYADRARKIKNKPIINIDPQAAELNHLKQQVQQLQVLLLQAHGGTLPGNINVKPSENLQSLM 390

Human   390 EKNQSLVEENEKLSRGLSEAAGQTAQMLERIILTEQANEKMNAKLEELRQHAACKLDLQKLVETL 454
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||:|||||.|||
  Rat   391 EKNQSLVEENEKLSRGLSEAAGQTAQMLERIILTEQANEKMNAKLEELRQHAACKVDLQKLAETL 455

Human   455 EDQELKENVEIICNLQQLITQLSDETVACMAAAIDTAVEQEAQVETSPETSRSSDAFTTQHALRQ 519
            ||||:|||:||||||||.|.:||||.||||.|.||||.|.:.|.::||:||||||.|:|||||||
  Rat   456 EDQEVKENIEIICNLQQAIARLSDEAVACMTATIDTAGEVDTQEQSSPDTSRSSDVFSTQHALRQ 520

Human   520 AQMSKELVELNKALALKEALARKMTQNDSQLQPIQYQYQDNIKELELEVINLQKEKEELVLELQT 584
            |||||||:||||.||||||||:||||||:||||||:|||||||.|||||::||||||||||||||
  Rat   521 AQMSKELIELNKELALKEALAKKMTQNDNQLQPIQFQYQDNIKNLELEVLSLQKEKEELVLELQT 585

Human   585 AKKDANQAKLSERRRKRLQELEGQIADLKKKLNEQSKLLKLKESTERTVSKLNQEIRMMKNQRVQ 649
            ||||.|||||||||||||||||||||:|||||:||||||||||:||.||||||||||||||||||
  Rat   586 AKKDVNQAKLSERRRKRLQELEGQIAELKKKLHEQSKLLKLKETTELTVSKLNQEIRMMKNQRVQ 650

Human   650 LMRQMKEDAEKFRQWKQKKDKEVIQLKERDRKRQYELLKLERNFQKQSNVLRRKTEEAAAANKRL 714
            |||||||||||||||||:|||||||||||||||||||||||||||||||||||||||||||||||
  Rat   651 LMRQMKEDAEKFRQWKQQKDKEVIQLKERDRKRQYELLKLERNFQKQSNVLRRKTEEAAAANKRL 715

Human   715 KDALQKQREVADKRKETQSRGMEGTAARVKNWLGNEIEVMVSTEEAKRHLNDLLEDRKILAQDVA 779
            |||||||:|||:||||||||||||||||:|:||||||||||||||||||||||||:|||||||||
  Rat   716 KDALQKQKEVAEKRKETQSRGMEGTAARMKSWLGNEIEVMVSTEEAKRHLNDLLEERKILAQDVA 780

Human   780 QLKEKKESGENPPPKLRRRTFSLTEVRGQVSESEDSITKQIESLETEMEFRSAQIADLQQKLLDA 844
            |||||:||||||||||||||||..||.||.|.:||||:|||||||:|:|.|||||||||||||||
  Rat   781 QLKEKRESGENPPPKLRRRTFSRDEVHGQDSGAEDSISKQIESLESELELRSAQIADLQQKLLDA 845

Human   845 ESEDRPKQRWENIATILEAKCALKYLIGELVSSKIQVSKLESSLKQSKTSCADMQKMLFEERNHF 909
            ||||:|||||||||||||||||:|||:|||||||||||||||.|.|||.||.::|||||||:|||
  Rat   846 ESEDQPKQRWENIATILEAKCAIKYLVGELVSSKIQVSKLESGLSQSKASCIEVQKMLFEEQNHF 910

Human   910 AEIETELQAELVRMEQQHQEKVLYLLSQLQQSQMAEKQLEESVSEKEQQLLSTLKCQDEELEKMR 974
            |:|||||:.||||:|||||||||||||||||.|:.||||||||||||||||||||||:|||.||:
  Rat   911 AKIETELKEELVRVEQQHQEKVLYLLSQLQQCQVTEKQLEESVSEKEQQLLSTLKCQEEELRKMQ 975

Human   975 EVCEQNQQLLRENEIIKQKLTLLQVASRQK-HLPKDTLLSPDSSFEYVPPKPKPSRVKEKFLEQS 1038
            ||||||||||:||..|||||.||||.|::| ||.::.|.||||||||:||||||.|:|||..|:|
  Rat   976 EVCEQNQQLLQENSAIKQKLNLLQVVSKEKPHLVRNILQSPDSSFEYIPPKPKPFRIKEKCPEKS 1040

Human  1039 MDIEDLKYCSEHSVNEHEDGDGDDDEGDDEEWKPTKLVKVSRKNIQGCSCKGWCGNKQCGCRKQK 1103
            ..||||:|.||.||.|.|:.|.||..  ||||.||||||||:|||||||||||||||||||||||
  Rat  1041 FAIEDLQYYSETSVAEEENEDSDDHA--DEEWIPTKLVKVSKKNIQGCSCKGWCGNKQCGCRKQK 1103

Human  1104 SDCGVDCCCDPTKCRNRQQGKDSLGTVERTQDSEGSFKLEDPTEVTPGLSFFNPVCATPNSKILK 1168
            |||...|.|||||||||...:|:...:|..||||.|||||||||||.|||||||||.||:|||||
  Rat  1104 SDCNGACSCDPTKCRNRHHSQDNSDVIELNQDSENSFKLEDPTEVTSGLSFFNPVCTTPSSKILK 1168

Human  1169 EMCDVEQVLSKKTPPAPSPFDLPELKHVATEYQENKAPGKKKKRALASNTSFFSGCSPIEEEAH 1232
            ||||.:|||.:: |...|..|..|||.:|:|.|||||.|||||||||||||||||||||:||:|
  Rat  1169 EMCDADQVLLRQ-PDFASSSDHLELKPIASETQENKAMGKKKKRALASNTSFFSGCSPIQEESH 1231

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KIF4A	NP_036442.3	KISc_KIF4	8..337	CDD:276823	312/329 (95%)
		SMC_prok_B	<375..714	CDD:274008	301/338 (89%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	496..515		11/18 (61%)
		Smc	558..>918	CDD:224117	323/359 (90%)
		Required for the interaction with PRC1. /evidence=ECO:0000269\|PubMed:15297875	663..1232		459/569 (81%)
		Nuclear localization signal. /evidence=ECO:0000269\|PubMed:11736643	793..798		4/4 (100%)
		Globular	1000..1232		163/232 (70%)
		Pre-SET	<1078..1120	CDD:368254	36/41 (88%)
		CRD, required for [4Fe-4S] cluster binding and localization to the spindle midzone and midbody during anaphase and telophase. /evidence=ECO:0000269\|PubMed:29848660	1086..1144		41/57 (72%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1122..1142		8/19 (42%)
Kif4a	XP_006257175.1	KISc_KIF4	8..338	CDD:276823	312/329 (95%)
		KISc	9..344	CDD:214526	317/334 (95%)
		HCR	390..1057	CDD:284517	571/666 (86%)
		COG4985	<494..638	CDD:227318	121/143 (85%)
		Cas1_I-II-III	<681..>744	CDD:294435	60/62 (97%)
		Pre-SET	<1070..1120	CDD:282838	43/49 (88%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83677929
Domainoid	1	1.000	1454	1.000	Domainoid score	I636
eggNOG	1	0.900	-	-		E2759_KOG0244
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H69022
Inparanoid	1	1.050	2075	1.000	Inparanoid score	I1306
NCBI	1	1.000	-	-
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D17141at9347
OrthoFinder	1	1.000	-	-		FOG0003140
OrthoInspector	1	1.000	-	-		otm52507
orthoMCL	1	0.900	-	-		OOG6_100464
Panther	1	1.100	-	-	LDO	PTHR47969
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2108
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	17.260