DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KIF4A and klp-19

DIOPT Version :9

Sequence 1:	NP_036442.3	Gene:	KIF4A / 24137	HGNCID:	13339	Length:	1232	Species:	Homo sapiens
Sequence 2:	NP_499742.1	Gene:	klp-19 / 176750	WormBaseID:	WBGene00002229	Length:	1083	Species:	Caenorhabditis elegans

Alignment Length:	1258	Identity:	359/1258 - (28%)
Similarity:	595/1258 - (47%)	Gaps:	238/1258 - (18%)

- Green bases have known domain annotations that are detailed below.

Human    10 VRVALRCRPLVPKEISEGCQMCLSFVPGEPQVVVGTDKSFTYDFVFDPSTEQEEVFNTAVAPLIK 74
            :||.:|.||:..:|..||...|:.|.....|:|:....:||:|.||..:::||.|:.|...||:.
Worm     7 LRVVVRARPMNGRETKEGASRCVQFYENTKQIVINESATFTFDAVFADTSDQESVYETTALPLLD 71

Human    75 GVFKGYNATVLAYGQTGSGKTYSMGGAYTAEQEN----EPTVGVIPRVIQLLFKEI-DKKSDFEF 134
            .:|.|:||||||||||||||||:||     .::|    |...|:|||::..||:.| :.::...|
Worm    72 RIFAGFNATVLAYGQTGSGKTYTMG-----TEDNVGTDEMRRGIIPRLVSALFQRIMNTEAPESF 131

Human   135 TLKVSYLEIYNEEILDLLCPSREKAQINIREDPKEGIKIVGLTEKTVLVALDTVSCLEQGNNSRT 199
            .:.||..|:|.:.:.|||.|  :|.::|:..|.| ...:|.||...|:.....:..|..|.:.||
Worm   132 AVTVSMFEVYGDNVYDLLRP--DKVKLNVHGDEK-NCTVVNLTAVPVIDLKGALKQLAVGCHYRT 193

Human   200 VASTAMNSQSSRSHAIFTISLEQRKKSDKNSSFRSKLHLVDLAGSERQKKTKAEGDRLKEGININ 264
            .|.||||:.||||||:||:.:|:...::.:|:|.:||.|||||||||.|||:|||:|:|||||||
Worm   194 KAETAMNAMSSRSHAVFTVFVEKTATAECDSAFSAKLQLVDLAGSERLKKTEAEGNRMKEGININ 258

Human   265 RGLLCLGNVISALGDDKKGGFVPYRDSKLTRLLQDSLGGNSHTLMIACVSPADSNLEETLNTLRY 329
            .|||.|..||:||...:|  .:|||:|.:||:|||||||||.|:.:||:||||||.:||||||||
Worm   259 GGLLILSQVIAALATKQK--HIPYRNSVITRVLQDSLGGNSFTVFLACISPADSNSQETLNTLRY 321

Human   330 ADRARKIKNKPIVNIDPQTAELNHLKQQVQQLQVLLLQAHGGTLPGSITVEPSENLQSLMEKNQS 394
            ||||::||||||||.:|:..|:..|:.|:::||........|..|..:....:.|...::...:.
Worm   322 ADRAKQIKNKPIVNKNPKAEEIAILQAQLKRLQKENADLKQGIAPAEVRFNDANNSAEILSLKEE 386

Human   395 LVEENEKLSRGLSEAAGQTAQMLERIILTEQANEKMNAKLEELRQHAACKLDLQKLV----ETLE 455
            :|.:.|:|.   ..|..|:..::....||::     |::|||      .|..||.::    .|:.
Worm   387 VVRKTEQLK---ERAMKQSECIIRMSALTQK-----NSRLEE------DKAKLQSMLTDVRNTVL 437

Human   456 DQELKENVEIICNLQQLITQLSDETVACMAAAIDTAVEQEAQVETSPETSRSSDAFTTQHALRQA 520
            ::|:.:..|::.::||::....:.|         |..:.:     :.||:......|.....|..
Worm   438 NEEMLDAAEVVRSIQQVVGDTEEST---------TLADDD-----NDETALGGQDDTIYDTERLP 488

Human   521 QMSKELVELNKALALKE-----------ALARKMTQNDSQLQPIQYQYQDNIKELELEVINLQKE 574
            ::..||.:|.|.:|:|:           |....|.|.:|:    :.|....|.|||.|:..|::|
Worm   489 ELQAELDDLEKQIAMKDENRQKALDEQRAFIEAMQQRESE----KTQLVVRISELETEMNKLRQE 549

Human   575 KEELVLELQTAKKDANQAKLSERRRKRLQELEGQIADLKKKLNEQSKLLKLKESTERTVSKLNQE 639
                      .||....|||:|.||::|::||.|.|:.||.||:..||.:.:...|.|:.|...|
Worm   550 ----------GKKVTTAAKLAEERRQKLKDLERQHAEDKKVLNDMKKLQETRRRMEETLKKTEDE 604

Human   640 IRMMKNQRVQLMRQMKEDAEKFRQWKQKKDKEVIQLKERDRKRQYELLKLERNFQKQSNVLRRKT 704
            ::.:|.||::|:|:.:.:|.||:.:|||.::|:.|:|.:.:||:.::...:|...::..||:.:.
Worm   605 LKNLKTQRLRLLREQRAEASKFQAFKQKHEREMAQMKSKLQKRENDVAIQKRMTDQKLTVLQMRL 669

Human   705 EEAAAANKRLKDALQKQREVADKRKETQSRGMEGTAARVKNWLGNEIEVMVSTEEAKRHLNDLLE 769
            .||..|||.|       ||:..||...:|.....:|  ::|.:..|:|..:..:.:.....||..
Worm   670 TEANRANKTL-------RELNLKRANRKSSPTNASA--LQNMIEEELEHEMCAQRSHWLCEDLRR 725

Human   770 DRKILAQDVAQLKEKKESGENPPPKLRRRTFSLTEVRGQVSESEDSI----TKQIESLETEMEFR 830
            .|..|.|::..::..|..|    .|.||.:.|.......|.|.|:..    .|::..|...:|..
Worm   726 QRHDLMQNINTVESMKFEG----GKRRRISASADPNVSVVIEGEEEFEVKRQKELTFLRASLETL 786

Human   831 SAQIADLQQKLLDAESEDRPKQRWENIATILEAKCALKYLIGELVSSKIQVSKLESSLKQSKT-- 893
            :.:|.|..:....|.:|:|...|||.:..  |.:.|.:.:..:.|:...:..:||..|.::|:
Worm   787 NEEIKDSLRNETIAGNEERANSRWEKVPA--EMRPAFEAVYAQAVAHIRKEIELEFKLARTKSEF 849

Human   894 SCADMQKMLFEERNHFAEIETELQAELVRMEQQHQ-------EKVLYLLSQLQQSQMAEKQLEES 951
            :.....|...||:.  .:.:.|::|:...:.|..:       ||:.:||..::::::.|..:::.
Worm   850 TAKIASKASHEEKR--KKEDEEMRAKYRELAQCLEDAKSGLHEKIAFLLCLIKENRVDENAIQQF 912

Human   952 VSEKEQQLLSTLKCQDEELEKMREVCEQNQQLLRENEIIKQKLTLLQVASRQKHLPKDTLLSPDS 1016
            .|.|.|                  .|:..|::.:              |||:|         ..:
Worm   913 ESLKNQ------------------FCDVEQKVKK--------------ASRRK---------TTN 936

Human  1017 SFEYVPPKPKPSRVKE-----KFLEQSMDIEDLKYCSEHSVNEHEDGDGDDDEGDDEEWKPTKLV 1076
            ....:.|||:..|.:.     |:....::.||:..                |:...::.|...|:
Worm   937 FMGGLTPKPELQRNERARRAVKYYGNVVNSEDVTM----------------DDSRHQKRKDHSLL 985

Human  1077 KVSRKNIQGCSCKGWCGNKQCGCRKQKSDCGVDCCCDPTKCRNRQQGKDSLGTVERTQDSEGSFK 1141
            .|........:.|          |:        ....|.||      .|.....|..:|.|..
Worm   986 AVEMNRTTDDNVK----------RR--------VAMSPIKC------DDDTRLTEEDEDIENE-- 1024

Human  1142 LEDPTEVTPGLSFFNPVCATPNSKILKEMCDVEQVLSKKTPPAPSPFDLPELKHVATEYQENKAP 1206
                              |..|:..:|:..:...::...:.|:|
Worm  1025 ------------------AMNNATFVKDSFNSATIVLDDSQPSP--------------------- 1050

Human  1207 GKKKKRALASNTSFFSGCSPIEE 1229
                     ||::|..|.:|..|
Worm  1051 ---------SNSTFVIGAAPTSE 1064

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KIF4A	NP_036442.3	KISc_KIF4	8..337	CDD:276823	159/331 (48%)
		SMC_prok_B	<375..714	CDD:274008	91/353 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	496..515		3/18 (17%)
		Smc	558..>918	CDD:224117	100/365 (27%)
		Required for the interaction with PRC1. /evidence=ECO:0000269\|PubMed:15297875	663..1232		109/585 (19%)
		Nuclear localization signal. /evidence=ECO:0000269\|PubMed:11736643	793..798		2/4 (50%)
		Globular	1000..1232		35/235 (15%)
		Pre-SET	<1078..1120	CDD:368254	6/41 (15%)
		CRD, required for [4Fe-4S] cluster binding and localization to the spindle midzone and midbody during anaphase and telophase. /evidence=ECO:0000269\|PubMed:29848660	1086..1144		9/57 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1122..1142		4/19 (21%)
klp-19	NP_499742.1	KISc	6..326	CDD:276812	158/328 (48%)
		SMC_prok_A	<342..621	CDD:274009	79/320 (25%)
		Smc	<481..825	CDD:224117	103/372 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	176	1.000	Domainoid score	I2406
eggNOG	1	0.900	-	-		E2759_KOG0244
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H69022
Inparanoid	1	1.050	467	1.000	Inparanoid score	I929
Isobase	1	0.950	-	0	Normalized mean entropy	S3090
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D74122at33208
OrthoFinder	1	1.000	-	-		FOG0003140
OrthoInspector	1	1.000	-	-		otm15465
orthoMCL	1	0.900	-	-		OOG6_100464
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3568
SonicParanoid	1	1.000	-	-		X2108
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.710