Protein Alignment KIF4A and klp-19

DIOPT Version :10

• Sequence 1: NP_036442.3
• Gene: KIF4A / 24137
• HGNCID: 13339
• Length: 1232
• Species: Homo sapiens
• Sequence 2: NP_499742.1
• Gene: klp-19 / 176750
• WormBaseID: WBGene00002229
• Length: 1083
• Species: Caenorhabditis elegans
• Alignment Length: 1258
• Identity: 359/1258 - (28%)
• Similarity: 595/1258 - (47%)
• Gaps: 238/1258 - (18%)

Human    10 VRVALRCRPLVPKEISEGCQMCLSFVPGEPQVVVGTDKSFTYDFVFDPSTEQEEVFNTAVAPLIK 74
            :||.:|.||:..:|..||...|:.|.....|:|:....:||:|.||..:::||.|:.|...||:.
 Worm     7 LRVVVRARPMNGRETKEGASRCVQFYENTKQIVINESATFTFDAVFADTSDQESVYETTALPLLD 71

Human    75 GVFKGYNATVLAYGQTGSGKTYSMGGAYTAEQEN----EPTVGVIPRVIQLLFKEI-DKKSDFEF 134
            .:|.|:||||||||||||||||:||     .::|    |...|:|||::..||:.| :.::...|
 Worm    72 RIFAGFNATVLAYGQTGSGKTYTMG-----TEDNVGTDEMRRGIIPRLVSALFQRIMNTEAPESF 131

Human   135 TLKVSYLEIYNEEILDLLCPSREKAQINIREDPKEGIKIVGLTEKTVLVALDTVSCLEQGNNSRT 199
            .:.||..|:|.:.:.|||.|  :|.::|:..|.| ...:|.||...|:.....:..|..|.:.||
 Worm   132 AVTVSMFEVYGDNVYDLLRP--DKVKLNVHGDEK-NCTVVNLTAVPVIDLKGALKQLAVGCHYRT 193

Human   200 VASTAMNSQSSRSHAIFTISLEQRKKSDKNSSFRSKLHLVDLAGSERQKKTKAEGDRLKEGININ 264
            .|.||||:.||||||:||:.:|:...::.:|:|.:||.|||||||||.|||:|||:|:|||||||
 Worm   194 KAETAMNAMSSRSHAVFTVFVEKTATAECDSAFSAKLQLVDLAGSERLKKTEAEGNRMKEGININ 258

Human   265 RGLLCLGNVISALGDDKKGGFVPYRDSKLTRLLQDSLGGNSHTLMIACVSPADSNLEETLNTLRY 329
            .|||.|..||:||...:|  .:|||:|.:||:|||||||||.|:.:||:||||||.:||||||||
 Worm   259 GGLLILSQVIAALATKQK--HIPYRNSVITRVLQDSLGGNSFTVFLACISPADSNSQETLNTLRY 321

Human   330 ADRARKIKNKPIVNIDPQTAELNHLKQQVQQLQVLLLQAHGGTLPGSITVEPSENLQSLMEKNQS 394
            ||||::||||||||.:|:..|:..|:.|:::||........|..|..:....:.|...::...:.
 Worm   322 ADRAKQIKNKPIVNKNPKAEEIAILQAQLKRLQKENADLKQGIAPAEVRFNDANNSAEILSLKEE 386

Human   395 LVEENEKLSRGLSEAAGQTAQMLERIILTEQANEKMNAKLEELRQHAACKLDLQKLV----ETLE 455
            :|.:.|:|.   ..|..|:..::....||::     |::|||      .|..||.::    .|:.
 Worm   387 VVRKTEQLK---ERAMKQSECIIRMSALTQK-----NSRLEE------DKAKLQSMLTDVRNTVL 437

Human   456 DQELKENVEIICNLQQLITQLSDETVACMAAAIDTAVEQEAQVETSPETSRSSDAFTTQHALRQA 520
            ::|:.:..|::.::||::....:.|         |..:.:     :.||:......|.....|..
 Worm   438 NEEMLDAAEVVRSIQQVVGDTEEST---------TLADDD-----NDETALGGQDDTIYDTERLP 488

Human   521 QMSKELVELNKALALKE-----------ALARKMTQNDSQLQPIQYQYQDNIKELELEVINLQKE 574
            ::..||.:|.|.:|:|:           |....|.|.:|:    :.|....|.|||.|:..|::|
 Worm   489 ELQAELDDLEKQIAMKDENRQKALDEQRAFIEAMQQRESE----KTQLVVRISELETEMNKLRQE 549

Human   575 KEELVLELQTAKKDANQAKLSERRRKRLQELEGQIADLKKKLNEQSKLLKLKESTERTVSKLNQE 639
                      .||....|||:|.||::|::||.|.|:.||.||:..||.:.:...|.|:.|...|
 Worm   550 ----------GKKVTTAAKLAEERRQKLKDLERQHAEDKKVLNDMKKLQETRRRMEETLKKTEDE 604

Human   640 IRMMKNQRVQLMRQMKEDAEKFRQWKQKKDKEVIQLKERDRKRQYELLKLERNFQKQSNVLRRKT 704
            ::.:|.||::|:|:.:.:|.||:.:|||.::|:.|:|.:.:||:.::...:|...::..||:.:.
 Worm   605 LKNLKTQRLRLLREQRAEASKFQAFKQKHEREMAQMKSKLQKRENDVAIQKRMTDQKLTVLQMRL 669

Human   705 EEAAAANKRLKDALQKQREVADKRKETQSRGMEGTAARVKNWLGNEIEVMVSTEEAKRHLNDLLE 769
            .||..|||.|       ||:..||...:|.....:|  ::|.:..|:|..:..:.:.....||..
 Worm   670 TEANRANKTL-------RELNLKRANRKSSPTNASA--LQNMIEEELEHEMCAQRSHWLCEDLRR 725

Human   770 DRKILAQDVAQLKEKKESGENPPPKLRRRTFSLTEVRGQVSESEDSI----TKQIESLETEMEFR 830
            .|..|.|::..::..|..|    .|.||.:.|.......|.|.|:..    .|::..|...:|..
 Worm   726 QRHDLMQNINTVESMKFEG----GKRRRISASADPNVSVVIEGEEEFEVKRQKELTFLRASLETL 786

Human   831 SAQIADLQQKLLDAESEDRPKQRWENIATILEAKCALKYLIGELVSSKIQVSKLESSLKQSKT-- 893
            :.:|.|..:....|.:|:|...|||.:..  |.:.|.:.:..:.|:...:..:||..|.::|:
 Worm   787 NEEIKDSLRNETIAGNEERANSRWEKVPA--EMRPAFEAVYAQAVAHIRKEIELEFKLARTKSEF 849

Human   894 SCADMQKMLFEERNHFAEIETELQAELVRMEQQHQ-------EKVLYLLSQLQQSQMAEKQLEES 951
            :.....|...||:.  .:.:.|::|:...:.|..:       ||:.:||..::::::.|..:::.
 Worm   850 TAKIASKASHEEKR--KKEDEEMRAKYRELAQCLEDAKSGLHEKIAFLLCLIKENRVDENAIQQF 912

Human   952 VSEKEQQLLSTLKCQDEELEKMREVCEQNQQLLRENEIIKQKLTLLQVASRQKHLPKDTLLSPDS 1016
            .|.|.|                  .|:..|::.:              |||:|         ..:
 Worm   913 ESLKNQ------------------FCDVEQKVKK--------------ASRRK---------TTN 936

Human  1017 SFEYVPPKPKPSRVKE-----KFLEQSMDIEDLKYCSEHSVNEHEDGDGDDDEGDDEEWKPTKLV 1076
            ....:.|||:..|.:.     |:....::.||:..                |:...::.|...|:
 Worm   937 FMGGLTPKPELQRNERARRAVKYYGNVVNSEDVTM----------------DDSRHQKRKDHSLL 985

Human  1077 KVSRKNIQGCSCKGWCGNKQCGCRKQKSDCGVDCCCDPTKCRNRQQGKDSLGTVERTQDSEGSFK 1141
            .|........:.|          |:        ....|.||      .|.....|..:|.|..
 Worm   986 AVEMNRTTDDNVK----------RR--------VAMSPIKC------DDDTRLTEEDEDIENE-- 1024

Human  1142 LEDPTEVTPGLSFFNPVCATPNSKILKEMCDVEQVLSKKTPPAPSPFDLPELKHVATEYQENKAP 1206
                              |..|:..:|:..:...::...:.|:|
 Worm  1025 ------------------AMNNATFVKDSFNSATIVLDDSQPSP--------------------- 1050

Human  1207 GKKKKRALASNTSFFSGCSPIEE 1229
                     ||::|..|.:|..|
 Worm  1051 ---------SNSTFVIGAAPTSE 1064

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KIF4A	NP_036442.3	KISc_KIF4	8..337	CDD:276823	159/331 (48%)
		PRK11281	383..>646	CDD:481316	68/277 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	496..515		3/18 (17%)
		Smc	<517..>1033	CDD:440809	132/544 (24%)
		Required for the interaction with PRC1. /evidence=ECO:0000269|PubMed:15297875	663..1232		109/585 (19%)
		Nuclear localization signal. /evidence=ECO:0000269|PubMed:11736643	793..798		2/4 (50%)
		Globular	1000..1232		35/235 (15%)
		CRD, required for [4Fe-4S] cluster binding and localization to the spindle midzone and midbody during anaphase and telophase. /evidence=ECO:0000269|PubMed:29848660	1086..1144		9/57 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1122..1142		4/19 (21%)
klp-19	NP_499742.1	KISc	6..326	CDD:276812	158/328 (48%)
		Smc	<339..>650	CDD:440809	90/352 (26%)
		YhaN	489..>919	CDD:443752	121/478 (25%)