DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zfp53 and CG5245

DIOPT Version :9

Sequence 1:	NP_038871.1	Gene:	Zfp53 / 24132	MGIID:	99200	Length:	652	Species:	Mus musculus
Sequence 2:	NP_650197.1	Gene:	CG5245 / 41530	FlyBaseID:	FBgn0038047	Length:	501	Species:	Drosophila melanogaster

Alignment Length:	503	Identity:	192/503 - (38%)
Similarity:	277/503 - (55%)	Gaps:	28/503 - (5%)

- Green bases have known domain annotations that are detailed below.

Mouse   153 VDLLNQDRHKSTHTGEELCKSEDCEKSLSLSSNLTENQRLYAANKLQSQGEYDDDFSSVYS---- 213
            :||.|.|:..   ..:|..:.:..|:.|...|| ::.:.|.:..|:::...|..|...|..
  Fly     1 MDLANVDQRP---VKDEPPQEDTFEEELIFISN-SDFEELESEIKIENFCSYGKDLEPVKGVPSK 61

Mouse   214 -------------LMQQTIYIGDTPHQCEKCRKCFSTASSLTVHKRIHTGKKPYKCSVCGKSFTQ 265
                         |.:||    || .:|.:|:|.|:...:|..|.|:|..::|::||.|.|||.:
  Fly    62 LKTCKSKIAKKRPLRKQT----DT-FKCTQCQKTFTRKENLESHLRLHAEERPFECSHCSKSFGR 121

Mouse   266 CTNLKTHQRLHTGEKPYKCKECGKSFPQLSALKSHQKIHTGERPYKCKECDKSFAHCSSFRRHQK 330
            .|:.|.|...|. ::|:||..|.|:|.|.|:||.|...||||||:||.:|..|||..|..:.|.:
  Fly   122 RTHYKRHLLKHE-KRPHKCSHCSKTFTQNSSLKQHLHEHTGERPFKCTQCSTSFARKSHLQVHLR 185

Mouse   331 THRAEEHCSCPECGKVLHQLSHLRSHYRLHTGEKPYKCNECDRSFTYYASYRRHQKTHSLDKFYK 395
            ||..|....|..|.|.....|||:.|.|.|...:|:||:.|.:||...:..::|..||: ::.:|
  Fly   186 THSEERPFECTHCEKAFKNNSHLQEHLRTHQEARPFKCSHCSKSFKLRSILQKHLLTHA-ERSFK 249

Mouse   396 CKECGKSFLELSHLKRHYRIHTGEKPYKCEVCDKSFTVNSTLKTHLKIHTGEKPFKCRECDKSFT 460
            |.:|.|:||:...|:.|.|:|.||.|:||..|.::|..||.|:.||..|.|::|.||.:|..:|.
  Fly   250 CTQCPKTFLQNDSLQIHLRVHAGEDPFKCPHCSETFARNSRLQLHLLEHAGKEPLKCSQCSATFA 314

Mouse   461 KCSHLRRHQSVHTGEKPYRCKECDKSFTECSTLRAHQKIHTGEKPYKCRECDKSFIQRSNLIIHQ 525
            ..|..|.|..:||.|:.|:|.||.|||.:.|.|..||::||||:|:||..|.|.|..|::|.:|.
  Fly   315 MRSLYRVHVRLHTRERQYKCAECSKSFFKKSHLVEHQQVHTGERPFKCTHCFKDFKCRTHLRVHM 379

Mouse   526 RVHTGERPYICKECGKSFTKCSTLQIHQKIHTGEKPYKCMECNKSFTQDSHLRTHQRVHTGERPY 590
            ..|.||:...|..|.|.|...|.|.:|.:.|||:..::|..|:||:|..|.|..|.|.||||.|:
  Fly   380 LDHIGEKVPKCSYCSKEFKLSSQLLVHLQEHTGKNQFECPHCSKSYTTSSTLHMHLRTHTGELPF 444

Mouse   591 ICKECGKSFTRCSYLRAHQKIHTGEKPYKCKDCDISFIQISNLRRHQR 638
            .|..|.|.|.|.:..:.|.:.|||||||||..|...:.|.|:|.||.|
  Fly   445 KCSHCSKLFARSAEHQEHLRTHTGEKPYKCSHCSTRYTQKSSLGRHLR 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zfp53	NP_038871.1	KRAB	53..93	CDD:396083
		COG5048	223..627	CDD:227381	169/403 (42%)
		C2H2 Zn finger	228..248	CDD:275368	7/19 (37%)
		C2H2 Zn finger	256..276	CDD:275368	9/19 (47%)
		C2H2 Zn finger	284..304	CDD:275368	9/19 (47%)
		C2H2 Zn finger	312..332	CDD:275368	7/19 (37%)
		C2H2 Zn finger	340..360	CDD:275368	8/19 (42%)
		C2H2 Zn finger	370..388	CDD:275368	4/17 (24%)
		C2H2 Zn finger	396..416	CDD:275368	8/19 (42%)
		C2H2 Zn finger	424..444	CDD:275368	8/19 (42%)
		C2H2 Zn finger	452..472	CDD:275368	6/19 (32%)
		C2H2 Zn finger	480..500	CDD:275368	10/19 (53%)
		C2H2 Zn finger	508..528	CDD:275368	7/19 (37%)
		C2H2 Zn finger	536..556	CDD:275368	7/19 (37%)
		C2H2 Zn finger	564..584	CDD:275368	9/19 (47%)
		C2H2 Zn finger	592..612	CDD:275368	6/19 (32%)
		C2H2 Zn finger	620..640	CDD:275368	8/19 (42%)
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	171/410 (42%)
		C2H2 Zn finger	84..104	CDD:275368	7/19 (37%)
		C2H2 Zn finger	112..132	CDD:275368	9/19 (47%)
		C2H2 Zn finger	139..159	CDD:275368	9/19 (47%)
		C2H2 Zn finger	167..187	CDD:275368	7/19 (37%)
		zf-H2C2_2	179..204	CDD:290200	7/24 (29%)
		C2H2 Zn finger	195..215	CDD:275368	8/19 (42%)
		C2H2 Zn finger	223..243	CDD:275368	5/19 (26%)
		C2H2 Zn finger	250..270	CDD:275368	8/19 (42%)
		C2H2 Zn finger	278..298	CDD:275368	8/19 (42%)
		C2H2 Zn finger	306..326	CDD:275368	6/19 (32%)
		C2H2 Zn finger	334..354	CDD:275368	10/19 (53%)
		C2H2 Zn finger	362..382	CDD:275368	7/19 (37%)
		C2H2 Zn finger	390..410	CDD:275368	7/19 (37%)
		C2H2 Zn finger	418..438	CDD:275368	9/19 (47%)
		C2H2 Zn finger	446..466	CDD:275368	6/19 (32%)
		C2H2 Zn finger	474..492	CDD:275368	7/17 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900