DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zfp53 and CTCF

DIOPT Version :9

Sequence 1:	NP_038871.1	Gene:	Zfp53 / 24132	MGIID:	99200	Length:	652	Species:	Mus musculus
Sequence 2:	NP_648109.1	Gene:	CTCF / 38817	FlyBaseID:	FBgn0035769	Length:	818	Species:	Drosophila melanogaster

Alignment Length:	330	Identity:	109/330 - (33%)
Similarity:	167/330 - (50%)	Gaps:	13/330 - (3%)

- Green bases have known domain annotations that are detailed below.

Mouse   329 QKTHRAEEHCSCPECGKVLHQLSHLRSHYRLHTGEKPYKCNECDRSFTYYASYRRHQKTHSLDKF 393
            |.::.:....|||.|.....:...:..|.|.|..|..:||:.|:|||......:.|..||..:|.
  Fly   285 QNSNASGHKYSCPHCPYTASKKFLITRHSRSHDVEPSFKCSICERSFRSNVGLQNHINTHMGNKP 349

Mouse   394 YKCKECGKSFLELSHLKRHYRI-HTGEKPYKCEVCDKSFTVNSTLKTHLKIHTGEKPFKCRECDK 457
            :|||.|..:|.....|.||.|. ||.|||:||..|..:....:.|:.|:..||||:|::|..|..
  Fly   350 HKCKLCESAFTTSGELVRHTRYKHTKEKPHKCTECTYASVELTKLRRHMTCHTGERPYQCPHCTY 414

Mouse   458 SFTKCSHLRRHQSVHTGEKPYRCKECDKSFTECSTLRAHQKIHT-GEKP-YKCRECDKSFIQRSN 520
            :......|:||..:|||||.|:|..|...||:.::|:||:.||: .:|| ::|..|..:..::::
  Fly   415 ASQDMFKLKRHMVIHTGEKKYQCDICKSRFTQSNSLKAHKLIHSVVDKPVFQCNYCPTTCGRKAD 479

Mouse   521 LIIH-QRVHTGERPYICKECGKSFTKCSTLQIHQKIHTGEKPYKCMECNKSFTQDSHLRTHQRVH 584
            |.:| :.:||.:.|..|:.||:........::|.|.|.|||.|.|..|:.:.....||.:|..:|
  Fly   480 LRVHIKHMHTSDVPMTCRRCGQQLPDRYQYKLHVKSHEGEKCYSCKLCSYASVTQRHLASHMLIH 544

Mouse   585 TGERPYICKECGKSFTRCSYLRAHQK-IHT--------GEKPYKCKDCDISFIQISNLRRHQRVH 640
            ..|:|:.|.:|.::|.:...||.|.. :|.        .||.:||..|...|....||.||...|
  Fly   545 LDEKPFHCDQCPQAFRQRQLLRRHMNLVHNEEYQPPEPREKLHKCPSCPREFTHKGNLMRHMETH 609

Mouse   641 TGEKN 645
            ....|
  Fly   610 DDSAN 614

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zfp53	NP_038871.1	KRAB	53..93	CDD:396083
		COG5048	223..627	CDD:227381	102/310 (33%)
		C2H2 Zn finger	228..248	CDD:275368
		C2H2 Zn finger	256..276	CDD:275368
		C2H2 Zn finger	284..304	CDD:275368
		C2H2 Zn finger	312..332	CDD:275368	1/2 (50%)
		C2H2 Zn finger	340..360	CDD:275368	5/19 (26%)
		C2H2 Zn finger	370..388	CDD:275368	5/17 (29%)
		C2H2 Zn finger	396..416	CDD:275368	8/20 (40%)
		C2H2 Zn finger	424..444	CDD:275368	4/19 (21%)
		C2H2 Zn finger	452..472	CDD:275368	5/19 (26%)
		C2H2 Zn finger	480..500	CDD:275368	7/19 (37%)
		C2H2 Zn finger	508..528	CDD:275368	4/20 (20%)
		C2H2 Zn finger	536..556	CDD:275368	5/19 (26%)
		C2H2 Zn finger	564..584	CDD:275368	5/19 (26%)
		C2H2 Zn finger	592..612	CDD:275368	6/20 (30%)
		C2H2 Zn finger	620..640	CDD:275368	7/19 (37%)
CTCF	NP_648109.1	23ISL	<116..206	CDD:293226
		C2H2 Zn finger	296..316	CDD:275368	5/19 (26%)
		COG5048	321..>621	CDD:227381	100/294 (34%)
		zf-C2H2	322..344	CDD:278523	7/21 (33%)
		C2H2 Zn finger	324..344	CDD:275368	6/19 (32%)
		zf-H2C2_2	337..361	CDD:290200	9/23 (39%)
		C2H2 Zn finger	352..373	CDD:275368	8/20 (40%)
		C2H2 Zn finger	381..401	CDD:275368	4/19 (21%)
		zf-H2C2_2	394..415	CDD:290200	9/20 (45%)
		C2H2 Zn finger	409..429	CDD:275368	5/19 (26%)
		zf-H2C2_2	422..446	CDD:290200	12/23 (52%)
		C2H2 Zn finger	437..457	CDD:275368	7/19 (37%)
		C2H2 Zn finger	467..485	CDD:275368	4/17 (24%)
		C2H2 Zn finger	496..516	CDD:275370	5/19 (26%)
		C2H2 Zn finger	524..544	CDD:275368	5/19 (26%)
		zf-H2C2_2	536..561	CDD:290200	9/24 (38%)
		C2H2 Zn finger	552..573	CDD:275368	6/20 (30%)
		zf-C2H2	587..609	CDD:278523	8/21 (38%)
		C2H2 Zn finger	589..609	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000