Protein Alignment Nelfa and Nelf-A

DIOPT Version :9

• Sequence 1: NP_036044.1
• Gene: Nelfa / 24116
• MGIID: 1346098
• Length: 530
• Species: Mus musculus
• Sequence 2: NP_001262804.1
• Gene: Nelf-A / 42520
• FlyBaseID: FBgn0038872
• Length: 1264
• Species: Drosophila melanogaster
• Alignment Length: 493
• Identity: 178/493 - (36%)
• Similarity: 249/493 - (50%)
• Gaps: 77/493 - (15%)

Mouse     1 MASMRESDTGLWLHNKLGATDELWAPPSIASLLTAAVIDNIRLCFHRLSSAVKLKLLLGTLHLPR 65
            ||::|:|||.||||||||.:::.|...||.|.|...|:.||:.||..|.:.|||||||..||:||
  Fly     1 MANVRDSDTSLWLHNKLGTSNDSWINGSICSQLNKEVLRNIKECFPDLQTQVKLKLLLSFLHIPR 65

Mouse    66 RTVDEMKAALMDIIQLATLDSDPWVLMVADILKSFPDTGSLNL---DLEEQNPNVQDILGELREK 127
            |.|:|.||.|.::|::|.|||:.||.|:|:.:|:||.|.|||.   |.|:..|...|::.:||:.
  Fly    66 RLVEEWKAELEEVIEVAGLDSELWVSMLAETMKTFPATSSLNTEISDYEDTRPIFIDMVNDLRKL 130

Mouse   128 VSECEASAMLPLECQYLNKNALTTLAGPLTPPVKHFQLKRKPKSATLRAELLQKSTETAQQLKRS 192
            |::.....||||||||||||||.::.|....|||||.||||||||.||.|||.||.:....||::
  Fly   131 VTKHSDLGMLPLECQYLNKNALISVVGQQPAPVKHFTLKRKPKSAQLRTELLHKSADAQSSLKKA 195

Mouse   193 AGVPFHAKGRGLLRKMDTTTPLKGIPKQAP---FRSPTTPSVFSPSGNRTPIPP-SRTPL-QKER 252
            :......:.||:.|||..||||||||.:.|   |||.|.|      ||....|. ||||. :|:.
  Fly   196 SAPTIPLRSRGMPRKMTDTTPLKGIPSRMPTTGFRSATVP------GNAAQRPNLSRTPAGRKDG 254

Mouse   253 GVKLLDISELNTVGAGREAKRRRKTLDTEVVEKPTKEETVVENATPDYAAGLVSTQKLGSLNSEP 317
            |:||::.:| ..:|.....||:|   :.::.|:..|:|...:.|....||...:... .:.:|.|
  Fly   255 GIKLIEFTE-QPLGYAAAKKRKR---EQQLEEQQKKQEQKQQQAAAAAAAAATAAAS-NAGDSSP 314

Mouse   318 TLPSTSYLPSTPSVVPASSYIPSSETPPAPPS-REASRPPEEP-------------SAPSPTLPT 368
            |..:|:....|| |.|.|:. .|.|....|.. .:::...|||             ...:|...|
  Fly   315 TDAATASGGETP-VTPTSAN-NSFEIKMEPQQLNQSAGSLEEPQDDEMSGKANMECDIETPEYAT 377

Mouse   369 QFKQRAPMYNSGLSPATPA-PAAPTSPLTPTTPPA------------------------------ 402
            .....|...::.::...|. ||..|...||.||.:
  Fly   378 ATLDFAQATSTSVADGQPGKPAVETKLKTPRTPKSAAKLNNNNNNNNNNSFNHTPKRIKQEIEIK 442

Mouse   403 ----VTPTA-------QTPPVAMVAPQTQAPAPVQQQP 429
                :.|.:       .:|....|:.|.|.|:.||:.|
  Fly   443 SEEIIVPASIKLEKIETSPSTQRVSIQQQPPSLVQRTP 480

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nelfa	NP_036044.1	NELF-C/D-binding. /evidence=ECO:0000255|PROSITE-ProRule:PRU01183	125..188		37/62 (60%)
		RNAPII-binding. /evidence=ECO:0000255|PROSITE-ProRule:PRU01183	189..248		27/62 (44%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	213..248		18/38 (47%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	266..296		7/29 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	312..409		27/152 (18%)
Nelf-A	NP_001262804.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831380
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_2CEBP
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0008325
OrthoInspector	1	1.000	-	-		oto94631
orthoMCL	1	0.900	-	-		OOG6_106554
Panther	1	1.100	-	-	LDO	PTHR13328
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4683
SonicParanoid	1	1.000	-	-		X6309
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	11	10.730