DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Usp18 and Usp47

DIOPT Version :9

Sequence 1:	NP_036039.2	Gene:	Usp18 / 24110	MGIID:	1344364	Length:	368	Species:	Mus musculus
Sequence 2:	NP_523937.2	Gene:	Usp47 / 38644	FlyBaseID:	FBgn0016756	Length:	1556	Species:	Drosophila melanogaster

Alignment Length:	426	Identity:	114/426 - (26%)
Similarity:	176/426 - (41%)	Gaps:	95/426 - (22%)

- Green bases have known domain annotations that are detailed below.

Mouse    26 EEERTMKRKRVLSRDLCSAWDS------------PHGLVGLHNIGQTCCLNSLLQVFMMNMDFRM 78
            :|.|..:|......|..|:..:            |.|.|||.|...||.||||||...|..:||.
  Fly   358 DELRAWQRVNTTGADFVSSATTETEAEARQASLGPRGYVGLVNQAMTCYLNSLLQALFMTPEFRN 422

Mouse    79 ILKRITVPRSAEERKRSVPFQLLLLLEKMQDSRQKAVLPTELVQCLQKYNVPLFVQHDAAQLYLT 143
            .|.|.......|  .:::|:||..|...:|.|.:.||..|:|.:.....:...:.|||..:|...
  Fly   423 ALYRWEFDNDNE--AKNIPYQLQKLFLNLQTSPKAAVETTDLTRSFGWDSTEAWQQHDIQELCRV 485

Mouse   144 IWNLTKDQITDTDLTERLQGLFTIWTQESLICVGCTAESSRRSKLLTLSLPLFDKDAKPL----- 203
            :::..:.:..:|.....:..|:.....:.:.|:.|..|.:|....|.:.||:     :|.
  Fly   486 MFDALEHKFKNTKQANLISNLYEGKMNDYVKCLECNTEKTREDTFLDIPLPV-----RPFGSSSA 545

Mouse   204 -KTLEDALRCFVQPKEL-ASSDMCCESCGEKTPWKQVLKLTHLPQTLTIHLMR--FSARNSRTEK 264
             .::|:|||.||||:.| .::...||.|.:|....:.|.....|..||:||.|  |..:.....|
  Fly   546 YGSIEEALRAFVQPETLDGNNQYLCEKCKKKCDAHKGLHFKSFPYILTLHLKRFDFDYQTMHRIK 610

Mouse   265 ICHSVNFPQSLDF---------------------------------------SQVLPT------E 284
            :...|.|||:|:.                                       |.|:.|      |
  Fly   611 LNDRVTFPQTLNLNTFINRSGNSGEQNSQLNGTVDDCSTADSGSAMEDDNLSSGVVTTASSSQHE 675

Mouse   285 EDLGDTKEQSEIH---------------YELFAVIAHVGMADFGHYCAYIRNPVDGKWFCFNDSH 334
            .||.|..|..::.               |||||::.|.|.|..|||.|||::..:.:||||||.:
  Fly   676 NDLNDEDEGIDMSSSTSKSAKQGSGPYLYELFAIMIHSGSASGGHYYAYIKDFDNNEWFCFNDQN 740

Mouse   335 VCWVTWKDVQCTYG-------NHRYRWRETAYLLVY 363
            |..:|.:|:|.::|       :..|.....||:|:|
  Fly   741 VTSITQEDIQRSFGGPNGSYYSSAYTSSTNAYMLMY 776

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp18	NP_036039.2	Mediates interaction with IFNAR2. /evidence=ECO:0000250\|UniProtKB:Q9UMW8	31..48		3/28 (11%)
		Mediates interaction with STAT2. /evidence=ECO:0000250\|UniProtKB:Q9UMW8	48..109		24/60 (40%)
		UCH	51..363	CDD:278850	106/387 (27%)
		Peptidase_C19	53..363	CDD:239072	105/385 (27%)
		Mediates interaction with STAT2 and necessary for the negative regulation of the type I IFN signaling pathway. /evidence=ECO:0000250\|UniProtKB:Q9UMW8	299..308		5/8 (63%)
		Mediates interaction with IFNAR2. /evidence=ECO:0000250\|UniProtKB:Q9UMW8	309..368		23/62 (37%)
Usp47	NP_523937.2	TEBP_beta	<119..234	CDD:254188
		Rib_recp_KP_reg	122..265	CDD:282899
		peptidase_C19C	394..780	CDD:239124	108/390 (28%)
		UCH	395..776	CDD:278850	106/387 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5077
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24006
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910