DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment prp-19 and PRP19

DIOPT Version :9

Sequence 1:	NP_001380015.1	Gene:	prp-19 / 24104882	WormBaseID:	WBGene00020423	Length:	492	Species:	Caenorhabditis elegans
Sequence 2:	NP_013064.1	Gene:	PRP19 / 850623	SGDID:	S000003959	Length:	503	Species:	Saccharomyces cerevisiae

Alignment Length:	522	Identity:	122/522 - (23%)
Similarity:	222/522 - (42%)	Gaps:	115/522 - (22%)

- Green bases have known domain annotations that are detailed below.

Worm     4 VCGISGELTEDPVVSQVSGHIFDRRLIVKFIAENGTDPISHGELSEDQLVSL--------KSGGT 60
            :|.|||::...||:|..|..||::.|:.:::.:.|.|||::..||.:::|.:        .:..|
Yeast     2 LCAISGKVPRRPVLSPKSRTIFEKSLLEQYVKDTGNDPITNEPLSIEEIVEIVPSAQQASLTEST 66

Worm    61 GSAPRNVSGTSIPSLLKMLQDEWDTVMLNSFSLRQQLQIARQELSHSLYQHDAACRVISRLSKEL 125
            .||... :..|||:||..||:|||.:||.:|.||..|....::||..:|:.|||..|.::|..|.
Yeast    67 NSATLK-ANYSIPNLLTSLQNEWDAIMLENFKLRSTLDSLTKKLSTVMYERDAAKLVAAQLLMEK 130

Worm   126 TAAREALSTLKPHTSAKVDDDVSIDESEDQQGLSEAILAKLEEKSKSLTAERKQRGKNLPEGLAK 190
            ....:.|    |.:|.:.   |:|...|..|||.::        |:...|..|.:....|  :.|
Yeast   131 NEDSKDL----PKSSQQA---VAITREEFLQGLLQS--------SRDFVARGKLKAPKWP--ILK 178

Worm   191 TEELAELKQTASHTGIHSTGTPGITALDIKGNLSLTGGIDKTVVLYDYEKEQVMQTFKGHNKKIN 255
            ..||.:.:..:.:          |.....| .|:.:...||.|.:...|...:..|....:|.|.
Yeast   179 NLELLQAQNYSRN----------IKTFPYK-ELNKSMYYDKWVCMCRCEDGALHFTQLKDSKTIT 232

Worm   256 AV------------------------VLHPDN-ITAISASADSHIRVWSATDSSSKAIIDVHQAP 295
            .:                        :|:|.| ||.:.:..:..:|
Yeast   233 TITTPNPRTGGEHPAIISRGPCNRLLLLYPGNQITILDSKTNKVLR------------------- 278

Worm   296 VTDISLNASGDYIL----SASDDSYWAFSDIRSGKSLCKVSVEPGSQIAVHS----IEF-----H 347
              :|.::::.:.|.    :..:..|:.::|.|.  ::...|.|..||..|||    :|:     |
Yeast   279 --EIEVDSANEIIYMYGHNEVNTEYFIWADNRG--TIGFQSYEDDSQYIVHSAKSDVEYSSGVLH 339

Worm   348 PDGLIFGTGAADAVVKIWDLKNQTVAAA-FP-GHTAAVRSIAFSENGYYLATGSEDGEVKLWDLR 410
            .|.|:....:.|.::.:::|.:...|:: || ...|.::.:.|::|||::.... |..|..:|||
Yeast   340 KDSLLLALYSPDGILDVYNLSSPDQASSRFPVDEEAKIKEVKFADNGYWMVVEC-DQTVVCFDLR 403

Worm   411 KLKNLKTFANEEKQPINSLSFDMTGTFLGIGGQKVQVLHVKSWSEVVSLSDHSGPVTGVRFGENA 475
              |::.|.|    .|..::....|||        |......|...:::.|:.|..:|..:|.:..
Yeast   404 --KDVGTLA----YPTYTIPEFKTGT--------VTYDIDDSGKNMIAYSNESNSLTIYKFDKKT 454

Worm   476 RS 477
            ::
Yeast   455 KN 456

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
prp-19	NP_001380015.1	RING-Ubox_PRP19	4..56	CDD:319570	18/59 (31%)
		Prp19	70..134	CDD:400774	26/63 (41%)
		SMC_prok_B	<74..>201	CDD:274008	38/126 (30%)
		WD40	213..491	CDD:238121	60/305 (20%)
		WD40 repeat	255..291	CDD:293791	6/60 (10%)
		WD40 repeat	296..335	CDD:293791	6/42 (14%)
		WD40 repeat	342..377	CDD:293791	9/44 (20%)
		WD40 repeat	383..418	CDD:293791	10/34 (29%)
		WD40 repeat	456..490	CDD:293791	4/22 (18%)
PRP19	NP_013064.1	RING-Ubox_PRP19	2..53	CDD:319570	18/50 (36%)
		Prp19	75..132	CDD:400774	25/56 (45%)
		WD40	<264..503	CDD:225201	48/231 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157622663
Domainoid	1	1.000	50	1.000	Domainoid score	I2732
eggNOG	1	0.900	-	-		E1_KOG0289
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003405
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102145
Panther	1	1.100	-	-	LDO	PTHR43995
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R276
SonicParanoid	1	1.000	-	-		X2757
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.770