Protein Alignment prp-19 and PRP19

DIOPT Version :10

• Sequence 1: NP_001380015.1
• Gene: prp-19 / 24104882
• WormBaseID: WBGene00020423
• Length: 492
• Species: Caenorhabditis elegans
• Sequence 2: NP_013064.1
• Gene: PRP19 / 850623
• SGDID: S000003959
• Length: 503
• Species: Saccharomyces cerevisiae
• Alignment Length: 522
• Identity: 122/522 - (23%)
• Similarity: 222/522 - (42%)
• Gaps: 115/522 - (22%)

 Worm     4 VCGISGELTEDPVVSQVSGHIFDRRLIVKFIAENGTDPISHGELSEDQLVSL--------KSGGT 60
            :|.|||::...||:|..|..||::.|:.:::.:.|.|||::..||.:::|.:        .:..|
Yeast     2 LCAISGKVPRRPVLSPKSRTIFEKSLLEQYVKDTGNDPITNEPLSIEEIVEIVPSAQQASLTEST 66

 Worm    61 GSAPRNVSGTSIPSLLKMLQDEWDTVMLNSFSLRQQLQIARQELSHSLYQHDAACRVISRLSKEL 125
            .||... :..|||:||..||:|||.:||.:|.||..|....::||..:|:.|||..|.::|..|.
Yeast    67 NSATLK-ANYSIPNLLTSLQNEWDAIMLENFKLRSTLDSLTKKLSTVMYERDAAKLVAAQLLMEK 130

 Worm   126 TAAREALSTLKPHTSAKVDDDVSIDESEDQQGLSEAILAKLEEKSKSLTAERKQRGKNLPEGLAK 190
            ....:.|    |.:|.:.   |:|...|..|||.::        |:...|..|.:....|  :.|
Yeast   131 NEDSKDL----PKSSQQA---VAITREEFLQGLLQS--------SRDFVARGKLKAPKWP--ILK 178

 Worm   191 TEELAELKQTASHTGIHSTGTPGITALDIKGNLSLTGGIDKTVVLYDYEKEQVMQTFKGHNKKIN 255
            ..||.:.:..:.:          |.....| .|:.:...||.|.:...|...:..|....:|.|.
Yeast   179 NLELLQAQNYSRN----------IKTFPYK-ELNKSMYYDKWVCMCRCEDGALHFTQLKDSKTIT 232

 Worm   256 AV------------------------VLHPDN-ITAISASADSHIRVWSATDSSSKAIIDVHQAP 295
            .:                        :|:|.| ||.:.:..:..:|
Yeast   233 TITTPNPRTGGEHPAIISRGPCNRLLLLYPGNQITILDSKTNKVLR------------------- 278

 Worm   296 VTDISLNASGDYIL----SASDDSYWAFSDIRSGKSLCKVSVEPGSQIAVHS----IEF-----H 347
              :|.::::.:.|.    :..:..|:.::|.|.  ::...|.|..||..|||    :|:     |
Yeast   279 --EIEVDSANEIIYMYGHNEVNTEYFIWADNRG--TIGFQSYEDDSQYIVHSAKSDVEYSSGVLH 339

 Worm   348 PDGLIFGTGAADAVVKIWDLKNQTVAAA-FP-GHTAAVRSIAFSENGYYLATGSEDGEVKLWDLR 410
            .|.|:....:.|.::.:::|.:...|:: || ...|.::.:.|::|||::.... |..|..:|||
Yeast   340 KDSLLLALYSPDGILDVYNLSSPDQASSRFPVDEEAKIKEVKFADNGYWMVVEC-DQTVVCFDLR 403

 Worm   411 KLKNLKTFANEEKQPINSLSFDMTGTFLGIGGQKVQVLHVKSWSEVVSLSDHSGPVTGVRFGENA 475
              |::.|.|    .|..::....|||        |......|...:::.|:.|..:|..:|.:..
Yeast   404 --KDVGTLA----YPTYTIPEFKTGT--------VTYDIDDSGKNMIAYSNESNSLTIYKFDKKT 454

 Worm   476 RS 477
            ::
Yeast   455 KN 456

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
prp-19	NP_001380015.1	RING-Ubox_PRP19	3..56	CDD:438318	18/59 (31%)
		Prp19	70..134	CDD:400774	26/63 (41%)
		SMC_prok_B	<74..>201	CDD:274008	38/126 (30%)
		WD40	<225..489	CDD:441893	57/293 (19%)
		WD40 repeat	255..291	CDD:293791	6/60 (10%)
		WD40 repeat	296..335	CDD:293791	6/42 (14%)
		WD40 repeat	342..377	CDD:293791	9/44 (20%)
		WD40 repeat	383..418	CDD:293791	10/34 (29%)
		WD40 repeat	456..490	CDD:293791	4/22 (18%)
PRP19	NP_013064.1	RING-Ubox_PRP19	1..53	CDD:438318	18/50 (36%)
		Prp19	75..132	CDD:400774	25/56 (45%)
		PRK11028	<385..459	CDD:182912	21/87 (24%)