Protein Alignment prp-19 and prpf19

DIOPT Version :10

• Sequence 1: NP_001380015.1
• Gene: prp-19 / 24104882
• WormBaseID: WBGene00020423
• Length: 492
• Species: Caenorhabditis elegans
• Sequence 2: XP_031760828.1
• Gene: prpf19 / 448017
• XenbaseID: XB-GENE-975233
• Length: 504
• Species: Xenopus tropicalis
• Alignment Length: 505
• Identity: 270/505 - (53%)
• Similarity: 346/505 - (68%)
• Gaps: 16/505 - (3%)

 Worm     1 MSFVCGISGELTEDPVVSQVSGHIFDRRLIVKFIAENGTDPISHGELSEDQLVSLKSGGTGSAPR 65
            ||..|.||.|:|:.|.:|.|||||||||||.|::|||||||:::..||||||:.:|.... ..|:
 Frog     1 MSLTCYISNEVTDRPCISPVSGHIFDRRLIEKYLAENGTDPVTNQPLSEDQLIDIKVAHP-IRPK 64

 Worm    66 NVSGTSIPSLLKMLQDEWDTVMLNSFSLRQQLQIARQELSHSLYQHDAACRVISRLSKELTAARE 130
            ..|.||||::||.||||||.|||:||:||||||..||||||:|||||||||||:||:||:|||||
 Frog    65 PPSATSIPAILKSLQDEWDAVMLHSFTLRQQLQTTRQELSHALYQHDAACRVIARLTKEVTAARE 129

 Worm   131 ALSTLKPHTSAKVDD-----------DVSIDESEDQQGLSEAILAKLEEKSKSLTAERKQRGKNL 184
            ||:||||.....|..           .....|..:..|:|..|:.||::|:..||.|||:|||.:
 Frog   130 ALATLKPQAGISVPQASPMPQAGAAGSAEAMELGELIGMSAEIIQKLQDKATVLTTERKKRGKTV 194

 Worm   185 PEGLAKTEELAELKQTASHTGIHSTGTPGITALDI---KGNLSLTGGIDKTVVLYDYEKEQVMQT 246
            ||.|.|.|||::..|.:||.|:||...|||.|||:   ..|.:||||.||:||::|...:|::.|
 Frog   195 PEDLVKPEELSKYHQVSSHVGLHSASVPGILALDLCPTDTNKTLTGGADKSVVVFDALSQQILAT 259

 Worm   247 FKGHNKKINAVVLHPDNITAISASADSHIRVWSATDSSSKAIIDVHQAPVTDISLNASGDYILSA 311
            .|||.||:.:||.||......|||.||.|||||..|:|...::..|:..||.:||:|:|||:||.
 Frog   260 LKGHTKKVTSVVFHPSQELVFSASPDSTIRVWSVPDASCAQVLRAHEGAVTGLSLHATGDYLLSC 324

 Worm   312 SDDSYWAFSDIRSGKSLCKVSVEPGSQIAVHSIEFHPDGLIFGTGAADAVVKIWDLKNQTVAAAF 376
            |||.|||||||..|:.|.||:.| .|..|:...:|||||||||||..|:.:||||||.::..|.|
 Frog   325 SDDQYWAFSDIHVGRVLTKVTDE-SSGCALTCAQFHPDGLIFGTGTVDSQIKIWDLKERSNVANF 388

 Worm   377 PGHTAAVRSIAFSENGYYLATGSEDGEVKLWDLRKLKNLKTFANEEKQPINSLSFDMTGTFLGIG 441
            |||:..|..||||||||||||.::|..|||||||||||.||...||...:.||.||.:||:|.:|
 Frog   389 PGHSGPVSCIAFSENGYYLATAADDSSVKLWDLRKLKNFKTLQLEEGYQVRSLVFDQSGTYLAVG 453

 Worm   442 GQKVQVLHVKSWSEVVSLSDHSGPVTGVRFGENARSLVTCSLDKSLRVFS 491
            |..:||...|.|:||:..:|||...||:.||:||:.|.:..:|:|||.:|
 Frog   454 GTDIQVYICKQWAEVLHFTDHSALTTGLAFGQNAKFLASTGMDRSLRFYS 503

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
prp-19	NP_001380015.1	RING-Ubox_PRP19	3..56	CDD:438318	32/52 (62%)
		Prp19	70..134	CDD:400774	51/63 (81%)
		SMC_prok_B	<74..>201	CDD:274008	75/137 (55%)
		WD40	<225..489	CDD:441893	140/263 (53%)
		WD40 repeat	255..291	CDD:293791	16/35 (46%)
		WD40 repeat	296..335	CDD:293791	24/38 (63%)
		WD40 repeat	342..377	CDD:293791	19/34 (56%)
		WD40 repeat	383..418	CDD:293791	26/34 (76%)
		WD40 repeat	456..490	CDD:293791	15/33 (45%)
prpf19	XP_031760828.1	RING-Ubox_PRP19	3..56	CDD:438318	32/52 (62%)
		Prp19	69..133	CDD:400774	51/63 (81%)
		WD40 repeat	224..262	CDD:293791	16/37 (43%)
		WD40	<233..504	CDD:441893	143/272 (53%)
		WD40 repeat	268..304	CDD:293791	16/35 (46%)
		WD40 repeat	309..344	CDD:293791	22/34 (65%)
		WD40 repeat	354..389	CDD:293791	19/34 (56%)
		WD40 repeat	395..431	CDD:293791	27/35 (77%)