Protein Alignment prp-19 and prpf19

DIOPT Version :10

• Sequence 1: NP_001380015.1
• Gene: prp-19 / 24104882
• WormBaseID: WBGene00020423
• Length: 492
• Species: Caenorhabditis elegans
• Sequence 2: NP_958875.1
• Gene: prpf19 / 321544
• ZFINID: ZDB-GENE-030131-263
• Length: 505
• Species: Danio rerio
• Alignment Length: 506
• Identity: 264/506 - (52%)
• Similarity: 353/506 - (69%)
• Gaps: 17/506 - (3%)

 Worm     1 MSFVCGISGELTEDPVVSQVSGHIFDRRLIVKFIAENGTDPISHGELSEDQLVSLKSGGTGSAPR 65
            ||.||.||.|:.|.|.||.||..:|:||||.|:|||||.|||:...|||:||:.:|.... ..|:
Zfish     1 MSLVCAISNEVPEHPCVSPVSNQVFERRLIEKYIAENGADPINGQPLSEEQLIDIKVSHP-IRPK 64

 Worm    66 NVSGTSIPSLLKMLQDEWDTVMLNSFSLRQQLQIARQELSHSLYQHDAACRVISRLSKELTAARE 130
            ..|.||||::||.||||||.|||:||:||||||..||||||:|||||||||||:||:||:|||||
Zfish    65 APSATSIPAILKSLQDEWDAVMLHSFTLRQQLQTTRQELSHALYQHDAACRVIARLTKEVTAARE 129

 Worm   131 ALSTLKPHT------SAKVDDDVSID------ESEDQQGLSEAILAKLEEKSKSLTAERKQRGKN 183
            ||:||||..      :|......::.      |..:|.|::..|:.||::|:..||.|||:|||.
Zfish   130 ALATLKPQAGLVAPQAAPASQPAAVGAGGEAMEVSEQVGMTPEIIQKLQDKATVLTTERKKRGKT 194

 Worm   184 LPEGLAKTEELAELKQTASHTGIHSTGTPGITALDI---KGNLSLTGGIDKTVVLYDYEKEQVMQ 245
            :||.|.:.|:|::.:|..||.|:||...|||.:||:   ..|..||||.||.||::|..:||::.
Zfish   195 VPEELVRAEDLSKYRQVGSHAGLHSASVPGILSLDLCPTDTNKVLTGGADKNVVVFDRREEQIVA 259

 Worm   246 TFKGHNKKINAVVLHPDNITAISASADSHIRVWSATDSSSKAIIDVHQAPVTDISLNASGDYILS 310
            |.|||.||:::|:.||......|||:||.|||||.|..:...::..|::.||.:||:|:|||:||
Zfish   260 TLKGHTKKVSSVIYHPAQAVVFSASSDSTIRVWSVTGGNCVQVVRAHESAVTGLSLHATGDYLLS 324

 Worm   311 ASDDSYWAFSDIRSGKSLCKVSVEPGSQIAVHSIEFHPDGLIFGTGAADAVVKIWDLKNQTVAAA 375
            :|:|.|||||||::|:.|.||:.|... .|:...:|||||||||||..|:.:||||||.:|..|.
Zfish   325 SSEDQYWAFSDIQTGRVLTKVTDETAG-CALTCAQFHPDGLIFGTGTGDSQIKIWDLKERTNVAN 388

 Worm   376 FPGHTAAVRSIAFSENGYYLATGSEDGEVKLWDLRKLKNLKTFANEEKQPINSLSFDMTGTFLGI 440
            ||||:..|.:|||||||||||||::|..:||||||||||.||...:....:.||.||.:||:|.:
Zfish   389 FPGHSGPVTAIAFSENGYYLATGAQDSSLKLWDLRKLKNFKTITLDNNYEVKSLVFDQSGTYLAV 453

 Worm   441 GGQKVQVLHVKSWSEVVSLSDHSGPVTGVRFGENARSLVTCSLDKSLRVFS 491
            ||..::|...|.||||::.|||||.||||.|||:|:.|.:..:|:||:.:|
Zfish   454 GGSDIRVYICKQWSEVLNFSDHSGLVTGVAFGEHAQFLASTGMDRSLKFYS 504

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
prp-19	NP_001380015.1	RING-Ubox_PRP19	3..56	CDD:438318	30/52 (58%)
		Prp19	70..134	CDD:400774	51/63 (81%)
		SMC_prok_B	<74..>201	CDD:274008	73/138 (53%)
		WD40	<225..489	CDD:441893	140/263 (53%)
		WD40 repeat	255..291	CDD:293791	14/35 (40%)
		WD40 repeat	296..335	CDD:293791	23/38 (61%)
		WD40 repeat	342..377	CDD:293791	20/34 (59%)
		WD40 repeat	383..418	CDD:293791	26/34 (76%)
		WD40 repeat	456..490	CDD:293791	18/33 (55%)
prpf19	NP_958875.1	Prp19	69..133	CDD:400774	51/63 (81%)
		WD40	224..504	CDD:238121	145/280 (52%)
		WD40 repeat	225..263	CDD:293791	16/37 (43%)
		WD40 repeat	269..305	CDD:293791	14/35 (40%)
		WD40 repeat	310..345	CDD:293791	21/34 (62%)
		WD40 repeat	355..390	CDD:293791	20/34 (59%)
		WD40 repeat	396..434	CDD:293791	27/37 (73%)
		WD40 repeat	439..465	CDD:293791	10/25 (40%)
		WD40 repeat	479..503	CDD:293791	12/23 (52%)
		RING-Ubox_PRP19	3..56	CDD:438318	30/52 (58%)