Protein Alignment prp-19 and prp19

DIOPT Version :9

• Sequence 1: NP_001380015.1
• Gene: prp-19 / 24104882
• WormBaseID: WBGene00020423
• Length: 492
• Species: Caenorhabditis elegans
• Sequence 2: NP_594874.1
• Gene: prp19 / 2542256
• PomBaseID: SPAC29A4.08c
• Length: 488
• Species: Schizosaccharomyces pombe
• Alignment Length: 508
• Identity: 144/508 - (28%)
• Similarity: 251/508 - (49%)
• Gaps: 96/508 - (18%)

 Worm     5 CGISGELTEDPVVSQVSGHIFDRRLIVKFIAENGTDPISHGELSEDQLVSLKSGGTGSAPRNVSG 69
            |.||||..::||:|:|||:::::|||.:.|.|...||::..|.:.:.||.:|.... ..||..|.
pombe     3 CSISGETPKEPVISRVSGNVYEKRLIEQVIRETSKDPVTQQECTLEDLVPVKVPDF-VRPRPPSA 66

 Worm    70 TSIPSLLKMLQDEWDTVMLNSFSLRQQLQIARQELSHSLYQHDAACRVISRLSKELTAAREALST 134
            ||:|:||.:.|:|||:|.|..|.||:.|...:||||.:||..|||.||||||:||...|||||:.
pombe    67 TSLPALLSLFQEEWDSVALEQFELRRNLTETKQELSTALYSLDAALRVISRLTKERDEAREALAK 131

 Worm   135 LKPH---TSAKVDD--DVSIDESEDQQGLSEAILAKLEEKSKSLTAERKQRGKNLPEGLAKTEEL 194
            ...:   .|:|..:  :|.:.||:||  |..::.:.:|:..:.|:::|| |.|..|: .|..:.:
pombe   132 FSDNIGTVSSKTIEVQEVEMGESDDQ--LKTSLRSTVEKTFQELSSKRK-RTKLQPK-WATDDAV 192

 Worm   195 AELKQTASHTGIHSTGTPGITALDIKGNLSLTGGIDKTVVLYDYEKEQVMQTFKGHNKKINAVVL 259
            ::|.|          .||                   :.:|.:.|.|.....|.........:.|
pombe   193 SQLLQ----------ATP-------------------STILENLETESTTSFFPSPENSSFVLCL 228

 Worm   260 HPDNITAISASADSHIRVWSAT-------DSSSKAI-----IDVHQAPVTDISLNA--------- 303
            |.|.:..:...::|.::::..:       .||..|:     |.:.:.||:...|.:
pombe   229 HKDELLCLDIQSNSTLKIFEGSALACCWLTSSKIAVATADAISIFEFPVSSSGLQSVGEPTSSIP 293

 Worm   304 ------------SGDYILSASDDSYWAFSDIRSGKSLCKVSVEPGSQIAVH--SIEFHPDGLIFG 354
                        ||:|:|:||::..:.|| ::|  .:..::|      |.|  |:..||||.:|.
pombe   294 IDEKVNFLQAHPSGEYLLAASNEKCYIFS-LKS--QVYNITV------AQHITSLAVHPDGNLFV 349

 Worm   355 TGAADAVVKIWDLKNQTVAAAFPGHTAAVRSIAFSENGYYL-ATGSEDGEVKLWDLRKLKNLKTF 418
            .|..:..::.::..:......|..|::.|:::.|.||||:| .|.::|.::.:|||||.:.::..
pombe   350 AGLENGELRFFETSSGNELTKFGPHSSPVKTLQFGENGYWLVVTTNDDSDIFIWDLRKSELVQKI 414

 Worm   419 ANEEKQPINSLSFDMTGTFLGIGGQKVQVLHV-----KSW-----SEVVSLSD 461
            ..:.|  :.::|.|:|...|.....:...:|:     |||     :.|.|:|:
pombe   415 PLQTK--VAAVSLDITSQLLVSSDGETLYVHIYVKSSKSWRCMSQTHVSSISN 465

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
prp-19	NP_001380015.1	RING-Ubox_PRP19	4..56	CDD:319570	21/50 (42%)
		Prp19	70..134	CDD:400774	37/63 (59%)
		SMC_prok_B	<74..>201	CDD:274008	52/131 (40%)
		WD40	213..491	CDD:238121	62/295 (21%)
		WD40 repeat	255..291	CDD:293791	8/47 (17%)
		WD40 repeat	296..335	CDD:293791	12/59 (20%)
		WD40 repeat	342..377	CDD:293791	8/36 (22%)
		WD40 repeat	383..418	CDD:293791	14/35 (40%)
		WD40 repeat	456..490	CDD:293791	3/6 (50%)
prp19	NP_594874.1	Ubox	1..66	CDD:128780	24/63 (38%)
		Prp19	67..130	CDD:285771	36/62 (58%)
		WD40	136..487	CDD:225201	82/374 (22%)
		WD40 repeat	252..293	CDD:293791	7/40 (18%)
		WD40	297..>484	CDD:295369	47/180 (26%)
		WD40 repeat	298..329	CDD:293791	9/33 (27%)
		WD40 repeat	337..371	CDD:293791	7/33 (21%)
		WD40 repeat	378..419	CDD:293791	14/40 (35%)
		WD40 repeat	427..459	CDD:293791	6/31 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	72	1.000	Domainoid score	I2286
eggNOG	1	0.900	-	-		E1_KOG0289
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	178	1.000	Inparanoid score	I993
OMA	1	1.010	-	-		QHG54686
OrthoFinder	1	1.000	-	-		FOG0003405
OrthoInspector	1	1.000	-	-		oto32173
orthoMCL	1	0.900	-	-		OOG6_102145
Panther	1	1.100	-	-	LDO	PTHR43995
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R276
SonicParanoid	1	1.000	-	-		X2757
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	11.900