DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tlr2 and Tehao

DIOPT Version :9

Sequence 1:	XP_006501523.1	Gene:	Tlr2 / 24088	MGIID:	1346060	Length:	794	Species:	Mus musculus
Sequence 2:	NP_001285901.1	Gene:	Tehao / 34761	FlyBaseID:	FBgn0026760	Length:	795	Species:	Drosophila melanogaster

Alignment Length:	761	Identity:	163/761 - (21%)
Similarity:	258/761 - (33%)	Gaps:	274/761 - (36%)

- Green bases have known domain annotations that are detailed below.

Mouse    56 IPSGLTAAMKSLDLSFNKITYI---GHGDLRAC--------ANLQVLMLKSSRINTIEGDAFYSL 109
            :.|..::..:|:....||:..|   |:.||...        .||:.|.|..:.|.|:..|.|..|
  Fly   267 LASATSSVNRSMFKGTNKLQLIKMNGNDDLMELPGEIFLDQVNLKTLDLSCNAIVTLHEDVFKGL 331

Mouse   110 GSLEHLDLSDNHLSSLSSSWFGPLSSLKYLNLMGNPYQTLGVTSLFPNLTNLQTLRIGNVETFSE 174
            |:|..||||.|.|::|||:.|.||:||..|.|..|....:. .|:|.::.:|..:.:.|.:
  Fly   332 GNLTLLDLSKNRLTNLSSTIFAPLTSLNVLRLNKNSLTAMS-PSVFQDVVSLNYIEMVNTQ---- 391

Mouse   175 IRRIDFAGLTSLNELEIKALSLRNYQSQSLKSIRDIHHLTLHLSESAFLLEIFADILSSVRYLEL 239
                 |.|.|.|  :..:|:...|.::...||
  Fly   392 -----FYGATLL--MNYEAVVCTNDEACQYKS--------------------------------- 416

Mouse   240 RDTNLARFQFSPLPVDEVSSPMKKLAFRGSVLTD---ESFNELLKLLRYILELSEVEFDDCTLNG 301
                 |.:|..|..:..|...:      ||::.|   .|..||..|.|..|
  Fly   417 -----AEWQCDPRCICWVQRSV------GSLIVDCRGTSLEELPDLPRTTL-------------- 456

Mouse   302 LGDFNPSESDVVSELGKVETVTIRRLHIPQFYLFYDLSTVYSLLEKVKRITVENSKVFLVPCSFS 366
                                                ||||         :.|.|:.:..:| :.|
  Fly   457 ------------------------------------LSTV---------LKVGNNSLTSLP-TVS 475

Mouse   367 QHLKSLEFLDLSENLMVEEYLKNSACKGAWPSLQTLVLSQNHLRSMQKTGEILLTLKNLTSLDIS 431
            :|                         ..:.::..|.||.|                |||||
  Fly   476 EH-------------------------SGYANVSGLFLSDN----------------NLTSL--- 496

Mouse   432 RNTFHPMPDSCQWPEKMRFLNLSSTGIRVVKTCIPQTLEVLDVSNNNLDSFS-LFLPRLQELYIS 495
                                   .:|.:     :|..|..|||..|.:.|.| .||..|||
  Fly   497 -----------------------GSGDQ-----LPDNLTHLDVRGNQIQSLSDEFLLFLQE---- 529

Mouse   496 RNKLKTLPDASLFPVLLVMKIRENAVSTFSKDQLGSFPKLETLEAGDNHFVCSCE---LLSFTME 557
                   |:.::                             ||....|...|.||   ||.|...
  Fly   530 -------PNNTM-----------------------------TLSLSGNPITCGCESLSLLFFVRT 558

Mouse   558 TPALAQILVDWPDSYLCDSPPRLHGHRLQDARPSVLECHQAALVSGVCCALLLLILLVGALCHHF 622
            .|...:.:.|...:....|..::....|..:...::.|....||..:|...:..::....|
  Fly   559 NPQRVRDIADIVCTKQKKSFQQMEAFELCPSYVLLISCVVGGLVIVICLLTVFYLMFQQEL---- 619

Mouse   623 HGLWYLR---MMWAWLQAKRKPKKAPCRDVCYDAFVSYSEQDSHWVENLMVQQLENSDPPFKLCL 684
             .:|...   .:| |:..:...|     |..||||:|||.:|...:..|: .:||:...||:|||
  Fly   620 -KIWLYNNNLCLW-WVSEEELDK-----DKTYDAFISYSHKDEELISKLL-PKLESGPHPFRLCL 676

Mouse   685 HKRDFVPGKWIIDNIIDSIEKSHKTVFVLSENFVRSEWCKYELDFSHFRLFDENNDAAILVLLEP 749
            |.||::.|..|.:.|:.:::.|.:.:.|||::|:.|.|.:.|...::.....:.....|::|...
  Fly   677 HDRDWLVGDCIPEQIVRTVDDSKRVIIVLSQHFIDSVWARMEFRIAYQATLQDKRKRIIIILYRE 741

Mouse   750 IER-KAIPQRFCKLRKIMNTKTYLEW--PLDEGQQEVFWVNLRTAI 792
            :|. ..|..   :||..:...|||:|  ||       ||..|..|:
  Fly   742 LEHMNGIDS---ELRAYLKLNTYLKWGDPL-------FWSKLYYAM 777

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tlr2	XP_006501523.1	internalin_A	<58..>259	CDD:380193	52/211 (25%)
		leucine-rich repeat	65..87	CDD:275378	7/32 (22%)
		LRR_8	87..145	CDD:338972	27/57 (47%)
		leucine-rich repeat	88..111	CDD:275378	8/22 (36%)
		leucine-rich repeat	112..135	CDD:275378	13/22 (59%)
		leucine-rich repeat	136..160	CDD:275378	6/23 (26%)
		leucine-rich repeat	186..212	CDD:275380	5/25 (20%)
		leucine-rich repeat	213..233	CDD:275380	0/19 (0%)
		PRK15370	<350..>568	CDD:185268	39/221 (18%)
		leucine-rich repeat	372..398	CDD:275380	0/25 (0%)
		leucine-rich repeat	399..424	CDD:275380	4/24 (17%)
		leucine-rich repeat	448..468	CDD:275380	2/19 (11%)
		leucine-rich repeat	469..488	CDD:275380	9/19 (47%)
		leucine-rich repeat	489..510	CDD:275380	4/20 (20%)
		leucine-rich repeat	511..534	CDD:275380	0/22 (0%)
		TPKR_C2	543..596	CDD:387596	11/55 (20%)
		TIR	650..794	CDD:214587	46/146 (32%)
Tehao	NP_001285901.1	leucine-rich repeat	185..207	CDD:275380
		leucine-rich repeat	209..232	CDD:275380
		leucine-rich repeat	233..261	CDD:275380
		LRR_RI	<261..370	CDD:238064	36/102 (35%)
		leucine-rich repeat	262..284	CDD:275380	2/16 (13%)
		leucine-rich repeat	285..309	CDD:275380	4/23 (17%)
		LRR_8	309..368	CDD:290566	28/58 (48%)
		leucine-rich repeat	310..333	CDD:275380	8/22 (36%)
		leucine-rich repeat	334..357	CDD:275380	13/22 (59%)
		leucine-rich repeat	358..381	CDD:275380	6/23 (26%)
		leucine-rich repeat	445..482	CDD:275380	14/121 (12%)
		LRR_8	459..516	CDD:290566	23/138 (17%)
		leucine-rich repeat	483..505	CDD:275380	11/68 (16%)
		LRR_4	486..521	CDD:289563	17/81 (21%)
		TIR	643..779	CDD:214587	46/146 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	1	1.000	-	-		FOG0000239
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24365
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X221
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.920