Protein Alignment Tlr2 and Toll-4

DIOPT Version :9

• Sequence 1: XP_006501523.1
• Gene: Tlr2 / 24088
• MGIID: 1346060
• Length: 794
• Species: Mus musculus
• Sequence 2: NP_523519.2
• Gene: Toll-4 / 34235
• FlyBaseID: FBgn0032095
• Length: 1125
• Species: Drosophila melanogaster
• Alignment Length: 789
• Identity: 179/789 - (22%)
• Similarity: 305/789 - (38%)
• Gaps: 206/789 - (26%)

Mouse    64 MKSLDLSFNKITYIGHGDLRACANLQVLMLKSSRINTIEGDAFYSLGSLEHLDLSDNHLSSLSSS 128
            :||||:|:|::|           :|.|..|..               ||.:||:..|.:::||..
  Fly   433 LKSLDVSYNQLT-----------SLSVSQLPE---------------SLHYLDIRHNKITTLSPQ 471

Mouse   129 WFGPLSSLKYLNLMGNPYQTLGVTSLFPNLTNLQTLRIGNVETFSEIRRIDFAGLTSLNELEIKA 193
            ....|.|:...|..||.:      |::.:..:||       |.|               ..:.|.
  Fly   472 VVEYLYSVNVFNQYGNKW------SIYCDEYHLQ-------EFF---------------WYKAKL 508

Mouse   194 LSLRNYQSQSLKSIRDIHHLTLHLSESAFLLEIFADILSSVRYLELRDTNLARFQFSPLPVDEVS 258
            |.::..:.|::....::.      |:.:|:...|...:..: |||..:             ||:.
  Fly   509 LRIKTSKFQTIMEYIELS------SKGSFVENFFVQNIDQL-YLEANE-------------DEII 553

Mouse   259 SPMKKLAFRGSVLTDESFN-ELLKLLRYILELSEVEFDDCTLNGLGDFNPSESDVVSELGKVE-T 321
            .     ||..|   |:.|| :|::.|.:.:.|...|||:..|:.|....|.......|....| .
  Fly   554 D-----AFGPS---DKYFNLKLMEALNHAIWLFSGEFDEIILHHLNSPCPYRCSCCFEWHTGEFL 610

Mouse   322 VTIRRL------HIPQFYLFYDLSTVYSLLEKVKRITVENSKVFLVPCSFSQHLKSLEFLDLSEN 380
            :..|.|      .:|....:  .:|:|....:::::|  |::..:|....|.|.     |.:|:|
  Fly   611 INCRNLSLDIYPRLPNSIPY--KTTLYLDRNEIRKLT--NTESLVVAGHASIHK-----LHMSQN 666

Mouse   381 LMVEEYLKNSACKGAWPSLQTLVLSQNHLRSMQKTGEI--LLTLKNLTSLDISRNTFHPMPDSCQ 443
            |:.|..|.      ..|...|.:..:|:|......|.|  |...:|:|.:::|.|   |...:|:
  Fly   667 LLRELPLH------LLPENITYLDVRNNLLKYLDDGVIAFLEYRENITKIELSGN---PWECNCK 722

Mouse   444 WPEKMRFLNLS-----STGIRVVK----TCIPQTLEVLDVSNNNLDSFSLF----------LPRL 489
            ....:.||...     .|.:|.|:    .|....:..:|.||:  ||.:..          :|:|
  Fly   723 AKAFLSFLRRHEPMEYETVLRRVEITDDKCPEDCICCVDTSNS--DSLAYVVDCSGKELSEIPQL 785

Mouse   490 -------QELYISRNKLKTLPDASLFP---VLLVMKIRENAVSTFSKDQLGSFPKLETLEAGDNH 544
                   ..|...||.||..| :||.|   .:....:..|.:|..  |||..  |||.|:..:|:
  Fly   786 PTPTYGQTTLVFERNSLKKWP-SSLLPGYSSVTRFYLAHNRLSDI--DQLPD--KLEYLDISNNN 845

Mouse   545 F-----------------------------VCSCELLSFTMETPALAQILVDWPDSYLCDSPPRL 580
            |                             .|.||...|.:.....|:.:.:.......|:...|
  Fly   846 FSALDDRVRGFLQKRMNSSQLQLSLFGNPWTCRCEDKDFLVFVKEQAKNIANASAIQCIDTGRSL 910

Mouse   581 HGHRLQDARPSVLECHQAALVSGVCCALLLLILLVGA-LCHHFHGLWYLR---MMWAW------- 634
            ......|..||||..:.:..||     ||::.|.:.. :|        .|   |:|.:
  Fly   911 IEVEETDICPSVLIYYTSLAVS-----LLIIALSINVFIC--------FRQPIMIWFYEHEICLS 962

Mouse   635 LQAKRKPKKAPCRDVCYDAFVSYSEQDSHWVENLMVQQLENSDPPFKLCLHKRDFVPGKWIIDNI 699
            |.|:|:..:    |..||||:|::.:|...:|. .|.:|||....|:||.:.||::.|:.|.|.|
  Fly   963 LAARRELDE----DKKYDAFLSFTHKDEDLIEE-FVDRLENGRHKFRLCFYLRDWLVGESIPDCI 1022

Mouse   700 IDSIEKSHKTVFVLSENFVRSEWCKYELDFSHFRLFDENNDAAILVLLEPIERKAIPQRFCKLRK 764
            ..|::.|.:.:.::::||::|.|.:.|...:......:.....|:||...:|.  ......:||.
  Fly  1023 NQSVKGSRRIIILMTKNFLKSTWGRLEFRLALHATSRDRCKRLIVVLYPDVEH--FDDLDSELRA 1085

Mouse   765 IMNTKTYLE 773
            .|...|||:
  Fly  1086 YMVLNTYLD 1094

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tlr2	XP_006501523.1	internalin_A	<58..>259	CDD:380193	38/194 (20%)
		leucine-rich repeat	65..87	CDD:275378	7/21 (33%)
		LRR_8	87..145	CDD:338972	14/57 (25%)
		leucine-rich repeat	88..111	CDD:275378	3/22 (14%)
		leucine-rich repeat	112..135	CDD:275378	7/22 (32%)
		leucine-rich repeat	136..160	CDD:275378	4/23 (17%)
		leucine-rich repeat	186..212	CDD:275380	3/25 (12%)
		leucine-rich repeat	213..233	CDD:275380	3/19 (16%)
		PRK15370	<350..>568	CDD:185268	62/277 (22%)
		leucine-rich repeat	372..398	CDD:275380	6/25 (24%)
		leucine-rich repeat	399..424	CDD:275380	6/26 (23%)
		leucine-rich repeat	448..468	CDD:275380	6/28 (21%)
		leucine-rich repeat	469..488	CDD:275380	5/28 (18%)
		leucine-rich repeat	489..510	CDD:275380	10/30 (33%)
		leucine-rich repeat	511..534	CDD:275380	5/22 (23%)
		TPKR_C2	543..596	CDD:387596	14/81 (17%)
		TIR	650..794	CDD:214587	37/124 (30%)
Toll-4	NP_523519.2	leucine-rich repeat	264..287	CDD:275380
		leucine-rich repeat	288..308	CDD:275380
		leucine-rich repeat	309..334	CDD:275380
		leucine-rich repeat	335..386	CDD:275380
		leucine-rich repeat	388..408	CDD:275380
		LRR_8	412..465	CDD:290566	15/57 (26%)
		leucine-rich repeat	412..432	CDD:275378
		LRR_4	432..470	CDD:289563	16/62 (26%)
		leucine-rich repeat	433..454	CDD:275378	10/46 (22%)
		leucine-rich repeat	455..478	CDD:275378	7/22 (32%)
		leucine-rich repeat	479..490	CDD:275378	3/16 (19%)
		leucine-rich repeat	632..657	CDD:275378	5/26 (19%)
		leucine-rich repeat	658..679	CDD:275378	8/31 (26%)
		leucine-rich repeat	680..706	CDD:275378	6/25 (24%)
		leucine-rich repeat	707..719	CDD:275378	4/14 (29%)
		leucine-rich repeat	771..791	CDD:275380	2/19 (11%)
		leucine-rich repeat	793..815	CDD:275378	9/22 (41%)
		leucine-rich repeat	816..835	CDD:275378	5/22 (23%)
		leucine-rich repeat	836..859	CDD:275378	5/22 (23%)
		TIR	974..1110	CDD:214587	37/124 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	1	1.000	-	-		FOG0000239
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24365
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X221
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.920