DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tll2 and CG42255

DIOPT Version :9

Sequence 1:	NP_036034.1	Gene:	Tll2 / 24087	MGIID:	1346044	Length:	1012	Species:	Mus musculus
Sequence 2:	NP_729748.3	Gene:	CG42255 / 39334	FlyBaseID:	FBgn0259140	Length:	3613	Species:	Drosophila melanogaster

Alignment Length:	1302	Identity:	281/1302 - (21%)
Similarity:	424/1302 - (32%)	Gaps:	444/1302 - (34%)

- Green bases have known domain annotations that are detailed below.

Mouse    11 VLLLLLPLPRGAEVTGDHSNVAL------DYGALEGEEG--TEQQL-------HYHDPCKAAVFW 60
            |.|.|:..|||.:|......|:|      .|..:|..:|  |:..|       |.....:..:..
  Fly   764 VCLYLIEQPRGTQVKLVIDRVSLVQSLSCHYLKIEIFDGRSTDAPLLRRICGSHEESELEPIISI 828

Mouse    61 GDIALDEDDLKL--FHIDKAEDWTKPSIDKPGHDTGGLEETSARWPNDTASNASIQAPRKDGKDA 123
            |::.|...:..|  ..:.|:.|.|...:     .||.....|.     ..|..:...|..|....
  Fly   829 GNVILVRYEYALSGVRLSKSFDLTYTRV-----CTGNFNTNSG-----IISTPNYPGPYFDDMTC 883

Mouse   124 TTFLPNP--------------GTSNTTAKT------FSARVRRATTSRTERIW------PGGVIP 162
            |..|..|              ||:|....|      .||..:|.....|:.:.      ...::.
  Fly   884 TYNLTGPLDTAVRMRITDLSLGTANNENDTSYLDVYLSADQKRHIVKSTDNLILLSHSNRASLVF 948

Mouse   163 YVIGG--------NFTGTQRAIF-KQAMRHWEKHTCVTFVERTDEESFIVFSYRTCGCCSYVGRR 218
            :..||        ||...|...| .:..|.:     ||.|..|..:.||.|.
  Fly   949 HGSGGGRGMRLEYNFVPNQCGGFLNEPGRRY-----VTAVRGTFCQWFIDFP------------- 995

Mouse   219 GGGPQAISIGKNCDKFGIVAHELGHVVGFWHEHTRPDRDQHVTIIRENIQPGQEYNFLKMEAGEV 283
              |.:.|||           |.||..             ..::|...:..||:..|...
  Fly   996 --GRKKISI-----------HTLGPT-------------PSISIYDNSTSPGKLVNSYS------ 1028

Mouse   284 SSLGETYDFDSIMHYARNTFSRGVFLDTILPRRDDNGVRPTIGQRVRLSQGDIAQARKLYKCPAC 348
            .|:|:.:|.|.:.          :.|.|..||.:...:           |.||.|.      .:|
  Fly  1029 GSVGDVFDGDLLT----------INLHTNWPRLEIYSI-----------QFDIVQQ------DSC 1066

Mouse   349 GETLQDTTGNFSAPGFPNGYPSYSHCVWRISVTPGEKIIL---NFTSMDLFKSRLCWYDYVEIRD 410
            |.|.....|...:|.:|..|.....|.|.:....|.:|.|   |||..:.:.|..||.|::|||:
  Fly  1067 GGTFTARFGYIKSPNWPKNYGESQMCEWILRAPFGHRIELVVHNFTLEEEYSSTGCWTDWLEIRN 1131

Mouse   411 GYWRKAPLLGRFCGDKIPESLVSSDSRLWVEFRSSSSSLGKGFFAVYEAM---CGG--------- 463
            |....:||:||:||::||..:.|..:.|.::|:|..|...|||...::.|   |||
  Fly  1132 GDSESSPLIGRYCGNEIPSRIPSFGNVLHLKFKSDDSMEEKGFLLSWQQMGAGCGGKLSSSMGTI 1196

Mouse   464 ----------------------------------------------------------------- 463

  Fly  1197 HSPHLLAGNRGILACDWQIIVAEGSRVSLQLRSNDNRICSGQLTLYDGPTTASNPIVIRCNGTIA 1261

Mouse   464 --------------DITKDA----------------------GQIQSPNYPDDYRPSKECVWRIT 492
                          |:..||                      |.|::||:|::|.|.::|.|.|.
  Fly  1262 KPLQSTGNRVLVRYDVGHDAPDGTDFMLNYQTNCRVRLEGLQGAIETPNFPENYPPGQDCEWDIR 1326

Mouse   493 VPD-GFHVGLTFQSFEIERHDS-CAYDYLEIRDGPTEDSTLI-GHFCGYEKPEAVKSSANRLWVK 554
            ... ..|:.|.|....:|:..| |..||:.:.| ..:|.||. .|.|..:..|.:.:..|||.::
  Fly  1327 AGGRKNHLQLIFSHLSVEKFSSICLNDYVSLVD-MLDDQTLSEQHLCTNDGLEPITTVGNRLLLR 1390

Mouse   555 FVSDGSINKAGFAANFFK---------------------EVD-ECSW---PDHGG---------- 584
            |.||.|:...||.|.:.:                     .|| :|.|   ...|.
  Fly  1391 FKSDSSVELQGFRAEYKRIGCGEHLRESGGRFESPNAPFSVDMDCVWIITASEGNQIRLLLHEVY 1455

Mouse   585 -------CEQR----CVNTLGSYTC------AC----------DPGYEL--------AADKK--- 611
                   |...    .|:....|..      :|          .||.||        |..:|
  Fly  1456 FEAPQIECRDAESSLSVSAPSGYNSSVVLFRSCHEETQTQTFTSPGNELVIRFVSSSAPSRKYFK 1520

Mouse   612 ----TCEVACGGFITKLNGTITSPGWPK--------EYPTNKNCVWQVVAPVQYRISLQFEAFEL 664
                ....:|||:|:..:|.:|:||:..        .|.:|..|||.|.....|.|...||.|.|
  Fly  1521 ASFVQVPASCGGYISASSGVLTTPGFHNHQDSKNVANYTSNIECVWTVEVTNGYGIRPHFEQFNL 1585

Mouse   665 EGNDVCKYDFVEVRSGLSPDAK--LHGKFCGSETPEVITSQSNNMRVEFKSDN------------ 715
            ..:..|...|||: :.|.||.|  ...|.||.::|.:.......:||.|||..
  Fly  1586 TDSGNCSVSFVEL-TKLEPDNKEIFLEKTCGEDSPMIRIVHGRKLRVRFKSQAGTWGRFIMYFER 1649

Mouse   716 ------------------------TVSKRGFRAHFFSDKDECAKDNG---GCQQ--ECVNTFGSY 751
                                    ..|..|.:.....::.||.|.|.   .|.:  :.:|.....
  Fly  1650 QCGGRLSTGEGYLQSRLDEECSWLVTSPEGSKLSLIINQLECPKCNAVSQNCSEGLQLLNDDDQV 1714

Mouse   752 LC--RCR----------NGYRLHENG------HDCKEAGCAYKISSAEGTLMSPNWPDKYPSRKE 798
            |.  .||          |..|:..:|      ....|..|...|:||.|:|.|||:||.||:..|
  Fly  1715 LLYQMCRDHPANLIVPANNVRILTHGIRLQAQFSTFENSCGGNITSASGSLSSPNYPDSYPANIE 1779

Mouse   799 CTWNISSTAGHRVKITFSEFEIEQHQECAYDHLELYDGTDSLAPILGRFCGSKKPDPVVATGSSL 863
            |.|:|.:..|:.::|||...:|.:.:.|..|.||:.....  .|:|..:|....|:..:...|.|
  Fly  1780 CVWSIRTRPGNALEITFEAMDIVRSEHCNDDFLEIRSSVQ--GPLLALYCDKNLPETPLVVHSEL 1842

Mouse   864 FLRFYSDASVQRKGFQ----AVHSTECGGRLKAEVQTKELYSHAQFGDNNYPSQARCDWVIVAED 924
            :::|.|.......||:    .||:.|....:...::...    ..|..|              ||
  Fly  1843 WIKFRSRPGNTAGGFRFRWTYVHNNEINSGINGTIEPPP----PLFVSN--------------ED 1889

Mouse   925 GYGVELIFRTFEVE-----EEADCGYDFMEAYDGYDSSAPRLG------RFCGSGPLEEIYSAGD 978
            ......:|..|:..     ||...|   :..:||||.:|..:.      ||..|..:..:.:..|
  Fly  1890 QPFTWRLFTDFKKVFVLQFEEYISG---LILFDGYDDNALAVNIPVSPWRFTSSSNVVYLKTVND 1951

Mouse   979 SL 980
            :|
  Fly  1952 AL 1953

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tll2	NP_036034.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	83..135		11/65 (17%)
		ZnMc_BMP1_TLD	147..346	CDD:239808	38/213 (18%)
		Astacin	154..347	CDD:279708	37/207 (18%)
		CUB	348..457	CDD:278839	39/111 (35%)
		CUB	461..570	CDD:278839	41/221 (19%)
		FXa_inhibition	581..613	CDD:291342	11/83 (13%)
		CUB	617..726	CDD:278839	39/154 (25%)
		FXa_inhibition	733..768	CDD:291342	11/57 (19%)
		CUB	773..882	CDD:278839	36/112 (32%)
		CUB	886..999	CDD:278839	19/106 (18%)
CG42255	NP_729748.3	EGF_CA	156..190	CDD:238011
		EGF_CA	192..233	CDD:238011
		EGF_CA	290..328	CDD:214542
		EGF_CA	330..374	CDD:214542
		EGF	427..455	CDD:278437
		EGF_CA	462..496	CDD:238011
		CUB	503..619	CDD:238001
		CUB	624..738	CDD:238001
		CUB	745..854	CDD:238001	21/89 (24%)
		CUB	857..963	CDD:238001	19/110 (17%)
		CUB	1066..1179	CDD:238001	39/112 (35%)
		CUB	1185..1293	CDD:238001	6/107 (6%)
		CUB	1303..1406	CDD:238001	35/103 (34%)
		CUB	1411..1523	CDD:238001	15/111 (14%)
		CUB	1530..1648	CDD:238001	37/118 (31%)
		CUB	1754..1862	CDD:238001	36/109 (33%)
		CUB	1979..2091	CDD:238001
		CUB	2096..2193	CDD:294042
		CUB	2210..2321	CDD:238001
		CUB	2327..2441	CDD:238001
		CUB	2688..2782	CDD:294042
		CUB	2810..2911	CDD:238001
		CUB	3029..3143	CDD:238001
		CUB	3169..3249	CDD:294042
		CUB	3499..3607	CDD:238001
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900