DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Smc1a and SMC1

DIOPT Version :9

Sequence 1:NP_062684.2 Gene:Smc1a / 24061 MGIID:1344345 Length:1233 Species:Mus musculus
Sequence 2:NP_651211.2 Gene:SMC1 / 42853 FlyBaseID:FBgn0040283 Length:1238 Species:Drosophila melanogaster


Alignment Length:1229 Identity:605/1229 - (49%)
Similarity:868/1229 - (70%) Gaps:23/1229 - (1%)


- Green bases have known domain annotations that are detailed below.


Mouse     3 FLKLIEIENFKSYKGRQIIGPFQRFTAIIGPNGSGKSNLMDAISFVLGEKTSNLRVKTLRDLIHG 67
            ||:.||:||||||:|..::||.::|.|:||||||||||.|||||||:|||||:||||.|.|||||
  Fly    26 FLEYIEMENFKSYRGHIVVGPLKQFNAVIGPNGSGKSNFMDAISFVMGEKTSSLRVKRLNDLIHG 90

Mouse    68 APVGKPAANRAFVS--MVYSEEGAEDRTFARVIVGGSSEYKINNKVVQLHEYSEELEKLGILIKA 130
            :.:|||.:...:|:  .|.:||...|  |.|.::||||||:||.:.|....|..:|||:||.:||
  Fly    91 SSIGKPVSRSCYVTAKFVLNEERHMD--FQRAVIGGSSEYRINGESVSSSTYLNKLEKIGINVKA 153

Mouse   131 RNFLVFQGAVESIAMKNPKERTALFEEISRSGELAQEYDKRKKEMVKAEEDTQFNYHRKKNIAAE 195
            :||||||||||:||||.||||||||||||.||.|..:|::.|:||:.|||:|||.|.:||.||||
  Fly   154 KNFLVFQGAVENIAMKTPKERTALFEEISGSGLLKDDYNRLKQEMIVAEEETQFTYQKKKGIAAE 218

Mouse   196 RKEAKQEKEEADRYQRLKDEVVRAQVQLQLFKLYHNEVEIEKLNKELASKNKEIEKDKKRMDKVE 260
            |||||.||.|||||.||::|....||:.|||:|:|.|.:|.|...:|..:.:|::..::|.:..:
  Fly   219 RKEAKHEKMEADRYTRLQNEYNEKQVEYQLFRLFHVERDIRKFTSDLEVRQQEVKAVEQRKEAAD 283

Mouse   261 DELKEKKKELGKMMREQQQIEKEIKEKDSELNQKRPQYIKAKENTSHKIKKLEAAKKSLQNAQKH 325
            :.|:||||:.||:.|:..:|::||:|.::::|::||.||||||..:|..|||.:.:|:|:.|::.
  Fly   284 EILREKKKDAGKITRDLAKIDQEIREFETQMNKRRPLYIKAKEKVTHCKKKLISLQKTLETAREA 348

Mouse   326 YKKRKGDMDELEKEMLSVEKARQEFEERMEEESQSQGRDLTLEENQVKKYHRLKEEASKRAATLA 390
            ....:.|:.:|||::..||..::.||:.:|.|||.:|:.:.:||..|::|.|||:||...|....
  Fly   349 DNAHQSDIRKLEKQLADVEALKKRFEDEIENESQRRGKSVNMEEGLVQEYDRLKQEAEATATQYR 413

Mouse   391 QELEKFNRDQKADQDRLDLEERKKVETEAKIKQKLREIEENQKRIEKLEEYITTSKQSLEEQKKL 455
            .||:..||:||::||.||.|..::...|...|:...:.||..||.:||.::|.:|:.:||||.::
  Fly   414 SELDSVNREQKSEQDTLDGETNRRASVEESFKKLTLQREEAVKRRDKLMDHIKSSQAALEEQNRI 478

Mouse   456 EGELTEEVEMAKRRIDEINKELNQVMEQLGDARIDRQESSRQQRKAEIMESIKRLYPGSVYGRLI 520
            :.||..:|..:|.:|.|..:||..|.:|||||:.|:.|.:|:::|.|::|..|:..|| ||.|:|
  Fly   479 KDELRRDVGTSKEKIAEKQRELEDVRDQLGDAKSDKHEDARRKKKQEVVELFKKQVPG-VYDRMI 542

Mouse   521 DLCQPTQKKYQIAVTKVLGKNMDAIIVDSEKTGRDCIQYIKEQRGEPETFLPLDYLEVKPTDEKL 585
            ::||||.|:|.:||||||||.|:|||||:|||.|.|||.:|||..|.|||||||||:|||..|:|
  Fly   543 NMCQPTHKRYNVAVTKVLGKFMEAIIVDTEKTARHCIQILKEQMLEVETFLPLDYLQVKPLKERL 607

Mouse   586 REL---KGAKLVIDVIRYEPPHIKKALQYACGNALVCDNVEDARRIAFG-GHQRHKTVALDGTLF 646
            |.:   :..:||.||:::||..|::|:.:|.||||||:..|||.::|:. ...|...:|||||.:
  Fly   608 RNISDPRNVRLVFDVLKFEPQEIERAVLFATGNALVCETPEDAMKVAYEIDRSRFDALALDGTFY 672

Mouse   647 QKSGVISGGASDLKAKARRWDEKAVDKLKEKKERLTEELKEQMKAKRKEAELRQVQSQAHGLQMR 711
            ||||:||||:.||..||:|||||.:.:||.:||||.|||||.:|..||::||..|:||..||:.|
  Fly   673 QKSGLISGGSHDLARKAKRWDEKHMAQLKMQKERLQEELKELVKKSRKQSELATVESQIKGLENR 737

Mouse   712 LKYSQSDLEQTKTRHLALNLQEKSKLESELANFGPRINDIKRIIQSREREMKDLKEKMNQVEDEV 776
            ||||..|||.:| :.::....:..:::|:|..|||:|.:|:|.:|:||..::::||.||.|||:|
  Fly   738 LKYSMVDLESSK-KSISQYDNQLQQVQSQLDEFGPKILEIERRMQNREEHIQEIKENMNNVEDKV 801

Mouse   777 FEEFCREIGVRNIREFEEEKVKRQNEIAKKRLEFENQKTRLGIQLDFEKNQLKEDQDKVHMWEQT 841
            :..|||.:||:|||::||.::..|.|.|:||.|||.|...:..||||||.  |:.:..|..||::
  Fly   802 YASFCRRLGVKNIRQYEERELVMQQERARKRAEFEQQIDSINSQLDFEKQ--KDTKKNVERWERS 864

Mouse   842 VKKDENEIEKLKKEEQRHMKIIDETMAQLQDLKNQHLAKKSEVNDKNHEMEEIRKKLGGANKEMT 906
            |:.:|:.:|.||..|.|::|.|||...:::..|....|||..|:|...::.:.||.:....||:.
  Fly   865 VQDEEDALEGLKLAEARYLKEIDEDKEKMEKFKQDKQAKKQAVDDMEEDISKARKDVANLAKEIH 929

Mouse   907 HLQKEVTAIETKLEQKRSDRHNLLQACKMQDIKLPLSKGTMDDISQEEGSSQGEESVSGSQRTSS 971
            ::...::|:|:|:|.|:::|.|:|...|...|.:||.:|::||..::          |.....|:
  Fly   930 NVGSHLSAVESKIEAKKNERQNILLQAKTDCIVVPLLRGSLDDAVRQ----------SDPDVPST 984

Mouse   972 IYAREALIEIDYGDLCEDLKDAQAEEEIKQEMNTLQQKLNEQQSVLQRIAAPNMKAMEKLESVRD 1036
            ..|.|.:||:||..|..:....:.:...|:....||:.|..:..||:||..|||||::||::|.:
  Fly   985 SAAMENIIEVDYSSLPREYTKLKDDSAFKKTHEMLQKDLQSKLDVLERIQTPNMKALQKLDAVTE 1049

Mouse  1037 KFQETSDEFEAARKRAKKAKQAFEQIKKERFDRFNACFESVATNIDEIYKALSRNSSAQAFLGPE 1101
            |.|.|::|||.|||:||:||.|||::|.||..||.||.:.::..||.|||.|:||.:|||::||:
  Fly  1050 KVQSTNEEFENARKKAKRAKAAFERVKNERSSRFVACCQHISDAIDGIYKKLARNEAAQAYIGPD 1114

Mouse  1102 NPEEPYLDGINYNCVAPGKRFRPMDNLSGGEKTVAALALLFAIHSYKPAPFFVLDEIDAALDNTN 1166
            |||||||||||||||||||||:||:||||||||:|||||||:.||:.||||||||||||||||||
  Fly  1115 NPEEPYLDGINYNCVAPGKRFQPMNNLSGGEKTIAALALLFSTHSFHPAPFFVLDEIDAALDNTN 1179

Mouse  1167 IGKVANYIKEQSTCNFQAIVISLKEEFYTKAESLIGVYPEQGDCVISKVLTFDLTKYPD 1225
            |||||:||::.:| |.|.||||||||||..|::|:|:.|.:|||::|.|...|||.:.|
  Fly  1180 IGKVASYIRDHTT-NLQTIVISLKEEFYGHADALVGITPGEGDCLVSNVYIMDLTTFED 1237

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Smc1aNP_062684.2 SMC_N 3..1210 CDD:308206 597/1212 (49%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 284..308 11/23 (48%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 348..369 7/20 (35%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 947..969 3/21 (14%)
SMC1NP_651211.2 Smc 26..1216 CDD:224117 595/1206 (49%)
ABC_SMC1_euk 27..>171 CDD:213242 87/145 (60%)
SMC_hinge 535..653 CDD:214944 70/118 (59%)
DUF4700 <697..>810 CDD:292399 52/113 (46%)
ABC_SMC1_euk <1130..1232 CDD:213242 72/102 (71%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 1151 1.000 Domainoid score I17
eggNOG 1 0.900 - - E1_COG1196
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H4597
Inparanoid 1 1.050 1171 1.000 Inparanoid score I200
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53603
OrthoDB 1 1.010 - - D326079at2759
OrthoFinder 1 1.000 - - FOG0001963
OrthoInspector 1 1.000 - - otm43758
orthoMCL 1 0.900 - - OOG6_101499
Panther 1 1.100 - - LDO PTHR18937
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1351
SonicParanoid 1 1.000 - - X1284
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1514.870

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