DRSC/TRiP Functional Genomics Resources

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Protein Alignment Scn11a and NaCP60E

DIOPT Version :9

Sequence 1:XP_017168851.1 Gene:Scn11a / 24046 MGIID:1345149 Length:1782 Species:Mus musculus
Sequence 2:NP_001261172.1 Gene:NaCP60E / 37981 FlyBaseID:FBgn0085434 Length:2896 Species:Drosophila melanogaster


Alignment Length:2524 Identity:748/2524 - (29%)
Similarity:1099/2524 - (43%) Gaps:817/2524 - (32%)


- Green bases have known domain annotations that are detailed below.


Mouse    37 TFDSLAAIEKRITI---QKEKKKSKDKAATEPQ-----PRPQLDLKASRKLPKLYGDVPPDLIAK 93
            ||:...|:.|...:   |:.:.|.:::.....:     ||.:..::....||:.:...|..:..|
  Fly     7 TFNDEKAVAKHQVVAYTQRSQVKHENRHIQLVREYGFHPRTKASVEDGDVLPRKFEPFPEHMYGK 71

Mouse    94 PLEDLDPFYKDHKTFMVLNK---KRTIYRFSAKRALFILGPFNPIRSFMIRISVHSVFSMFIICT 155
            |||::|.|..: :||.|::|   |..|:||:..::||:..|::|.|...:.|:.:..|...::.|
  Fly    72 PLEEIDTFIYE-ETFCVVSKRFRKNYIHRFTGTKSLFLFYPWSPARRVCVYIATNQFFDYCVMAT 135

Mouse   156 VIINCMFMANNSSVDSRPSSNIPEYVFIGIYVLEAVIKILARGFIVDEFSYLRDPWNWLDFIVIG 220
            ::.||:|:|...:|:.      .||:|:.||.:|.||||:|:||::::::|||:|||||||:||.
  Fly   136 ILFNCIFLAMTETVEE------AEYIFLAIYSIEMVIKIIAKGFLLNKYTYLRNPWNWLDFVVIT 194

Mouse   221 TAIAPCFLGNKVNNLSTLRTFRVLRALKAISVISGLKVIVGALLRSVKKLVDVMVLTLFCLSIFA 285
            :..|.  :|.:|.||:.|||||||||||.:|::.|||.|:.|||.|.::|.:||.||:|||.:||
  Fly   195 SGYAT--IGMEVGNLAGLRTFRVLRALKTVSIMPGLKTIINALLHSFRQLAEVMTLTIFCLMVFA 257

Mouse   286 LVGQQLFMGILSQKCIKDDCGPNAFSN---KDCFVKENDSEDF--------IMCGNWLGRRSCPD 339
            |...|::||.|..||::.  .|..::|   .|..:..||::::        ::|||..|.|.||.
  Fly   258 LFALQVYMGELRNKCVRQ--VPTDWTNVSHTDWQIWVNDTDNWLYDEDELPVLCGNLTGARHCPF 320

Mouse   340 GSTCNKTTFNPDYNYTNFDSFGWSFLAMFRVMTQDSWEKLYRQILRTSGIYFVFFFVVVIFLGSF 404
            ...|.....||::.|||||:|.||.|..|:::|.|.||.:|..:|.|.|...|.||.||:|.|||
  Fly   321 EYVCLCVGENPNHGYTNFDNFMWSMLTTFQLITLDYWENVYNMVLATCGPMSVSFFTVVVFFGSF 385

Mouse   405 YLLNLTLAVVTMAYEEQNRNVAAETEAKEKMFQEAQQLLREEKEALVAMGIDRTSLNSLQA---- 465
            ||:||.||||.::|||: ..:..|...|:.:..........:...|....:::.:...:.:    
  Fly   386 YLINLMLAVVALSYEEE-AEITNEERKKDLLDHRDDSTFSFDPSVLNVKKLNKNNKKKIDSRKGV 449

Mouse   466 --SSFSPKK---RKFFGSKTRKSFFMRGSKTARASASDSEDD----------------------- 502
              :|:|.||   :|..|.|       .|......:.|:.:|:                       
  Fly   450 LLASYSKKKTRRKKTKGGK-------EGGTNGNGNGSNGDDNKSHSATPSPGPSPRHSATERPSA 507

Mouse   503 ----ASKNPQLLEQTKRLSQ------NLPVE---------------------------------- 523
                |.|..|.:||..:|::      |.|:.                                  
  Fly   508 LTMQAQKQYQQMEQQHKLAKSGSGGSNNPMAPTPKGRISFQDSGMGVKNPNMLYPSDYKGQLIAN 572

Mouse   524 ---------------------LFDEHVDPLHRQRALSAVSILTITMQEQEKSQEPCFPCGKNLA- 566
                                 :.|:| :.......:..||.:.:.:..:|..   ...|..|:| 
  Fly   573 SGQPSSNSSGVNRESSQDDSGVVDDH-EEQDTTNDMGHVSTVELALSPREVR---LIKCNGNIAR 633

Mouse   567 --------------SKYLVWECSP---------------PWLCIKKVLQTIMTDPFTELAITICI 602
                          |:.:|.:..|               .||..:..|..::.||..|||||:||
  Fly   634 IKNHNVYALHQEFSSEVVVIDDLPDRNCDRCVHWCTDYESWLQFQNCLYKVVRDPLFELAITLCI 698

Mouse   603 IVNTVFLAMEHHNMDNSLKDILKIGNWVFTGIFIAEMCLKIIALDPYHYFRHGWNIFDSIVALVS 667
            ::||.|||||||.|..|.::.|.:||.|||.||..|..:|::||.. .:|..||||||.::...|
  Fly   699 VLNTAFLAMEHHGMSESFRNALDVGNKVFTSIFTFECIVKLMALSK-DFFLCGWNIFDLLIVTAS 762

Mouse   668 LADVLFHKLSKNLSFLASLRVLRVFKLAKSWPTLNTLIKIIGHSVGALGNLTVVLTIVVFIFSVV 732
            |.|::| :|...||.|..||:|||.|||:||.|:..|:.||..::|||||||::|.||::||:|:
  Fly   763 LLDIIF-ELVDGLSVLRGLRLLRVLKLAQSWTTMKVLLSIIISTIGALGNLTLILVIVIYIFAVI 826

Mouse   733 GMRLFGAKFNKTCSTSPESLRRWHMGDFYHSFLVVFRILCGEWIENMWECM--QEMEGSPLCVIV 795
            ||:||...:... ...|:.:.||:..||:|||:::||||||||||.:|:||  :|.:|:..|..:
  Fly   827 GMQLFSKDYTPE-KFDPDPVPRWNFNDFFHSFMMIFRILCGEWIEPLWDCMRAEEEQGASTCFAI 890

Mouse   796 FVLIMVVGKLVVLNLFIALLLNSFSNEE--------------------------------KD--- 825
            |:..:|:|..:|||||:|||||||::||                                ||   
  Fly   891 FLPTLVMGNFMVLNLFLALLLNSFNSEELKSKKEEVGEESKLARSIERVRDLIRKKRQERKDRKE 955

Mouse   826 --------------------------------GNPEGETRKTK---------------------- 836
                                            |:..|...:||                      
  Fly   956 RKFAEKFQQIVLDAQQAHAQTLSHQAAVGLERGDKPGVLAETKFHRLSYQESMNRPVSGSDFGFQ 1020

Mouse   837 -------------------------VQL------------------------------------- 839
                                     :||                                     
  Fly  1021 IPLHDGLHTIVDGLEYDDTGDLPEQIQLQAHPLPPTSDSMPPTYESAMMATTGGSFSSVNGNGTC 1085

Mouse   840 ----------------------------------------------------------------- 839
                                                                             
  Fly  1086 QNLTPFVQAERRLQHQISSGVSTQQYDSREEATYTESIELLGQYNSTDTDPYANDQRSGCGSFNR 1150

Mouse   840 -------------------------------------ALDRFSRA-------------------- 847
                                                 :|||.|::                    
  Fly  1151 GDSLQDNSSRRYGSEEHDEAFLKYQKSLLTRSPSYRKSLDRLSQSSGQSQRSLLKSEEAEMRRHS 1215

Mouse   848 ----------------------------------FYFM-----------ARALQNFCCKRCRRQN 867
                                              |.|:           .|.:.|  ..|.||.:
  Fly  1216 SGQSLNSMSIEQDELLSQQGNLREELLNCDQKELFQFLQEEEELQKGTKLRRISN--VMRSRRPS 1278

Mouse   868 SP--KPNEAT-----------ESFAGE----SRDTATLDTR-------------SWKEYDSEMTL 902
            |.  :|...|           :||..|    .|.|.:|:.:             :.|.....:.:
  Fly  1279 SQMGQPENETMVEHSEFDNIIQSFEKELEEIKRSTTSLERKLSNLSEPSPAADEATKAIMEHIAI 1343

Mouse   903 YTG--------QAGAPLAP-------------------------------LAKE---EDDMECCG 925
            .||        :...||.|                               |.|:   ::|.....
  Fly  1344 ITGASERSAADEVVLPLNPYDSYDLSSVPRRSQSVSAAAQRQSVKLKRRSLEKQRKIDEDFSISN 1408

Mouse   926 E----CD---------------ASPTSQ-----------------------------------PS 936
            |    ||               |:..||                                   |.
  Fly  1409 EIRKICDQIHAPFVAMEAMAVAATSASQAQPNQSPFLRRKVDPFTVQFDRFKRLSLIERVEEVPE 1473

Mouse   937 EEAQACDLPLKTKRLPSPDDHG------------------------------------------- 958
            ||.....|.::::::|....||                                           
  Fly  1474 EEKPISTLRIESEKMPRKFLHGPDQLRLDSLSLKSTNSYENLLIQKQKLGMATPPAVPATPPTSL 1538

Mouse   959 ---VEMEVFSE----------------------------------------------------ED 968
               :|....::                                                    |.
  Fly  1539 KSSIEPPTLAQISSLKTTPPLAALTEHQQHFHATSIQAAPTPAHTHAHSQAHAHSMAGQRRRMEH 1603

Mouse   969 PNLTI------QSARKKS------DAASMLS--------------------------------EC 989
            |..|:      ||||.:|      ||:|.|:                                .|
  Fly  1604 PQSTLDKAASFQSARTESHSSGAADASSALALAMAQKTEQSQSTAPDATQKPSAFTRLTEKPWHC 1668

Mouse   990 STIDLNDIF----RNLQ------------KTVSPQKQPDRCFPKGLSCIFLCCKTIKKKSPWVL- 1037
            ....::|:.    ||.|            ......|.||.|||:      .|......:.||.: 
  Fly  1669 LVSYVDDLTVGGRRNSQGAYNDPMTFPSYGATKAAKVPDDCFPQ------KCYDHFYFRCPWFMS 1727

Mouse  1038 ---------WWNLRKTCYQIVKHSWFESFIIFVILLSSGALIFEDVNLPSRPQVEKLLKCTDNIF 1093
                     |..:|.....:|....||.|::.:|..||..|.|||:||.....::::|...:..|
  Fly  1728 CMDTQSAKHWTRVRTAVLTVVDTPAFEWFVLVLIFASSITLCFEDINLDKNKTLKRVLYWINFSF 1792

Mouse  1094 TFIFLLEMILKWVAFGFRKYFTSAWCWLDFLIVVVSGLSL-----TNLPNLKSFRNLRALRPLRA 1153
            ..||::||||||:|.||.|||||.|..|||:||.||..||     .||..|:|.|.|||||||||
  Fly  1793 CLIFVVEMILKWLALGFSKYFTSFWTILDFIIVFVSVFSLLIEENENLKVLRSLRTLRALRPLRA 1857

Mouse  1154 LSQFEGMKVVVNALMSAIPAILNVLLVCLIFWLIFCILGVNFFSGKFGRCINGTDINKYFNASNV 1218
            :|:::||::||||||.|||:|.|||||||:|||||.|:||.||.|||.:|:|  ::.:....:.|
  Fly  1858 ISRWQGMRIVVNALMYAIPSIFNVLLVCLVFWLIFSIMGVQFFGGKFFKCVN--EMGELLPITEV 1920

Mouse  1219 PNQSQCLVSNYTWKVPNVNFDNVGNAYLALLQVATYKGWLDIMNAAVDSRGKDEQPAFEANLYAY 1283
            .::..|:..||||....:.||:||..|||||||||::||:::|..|||:||.|.||..|||||||
  Fly  1921 NDKWDCIEQNYTWINSKITFDHVGMGYLALLQVATFEGWMEVMADAVDARGVDLQPQREANLYAY 1985

Mouse  1284 LYFVVFIIFGSFFTLNLFIGVIIDNFNQQQKKISG--QDIFMTEEQKKYYNAMKKLGTKKPQKPI 1346
            :|||:||:.||||||||||||||||||..:||..|  .::|:||.||.||.||||||.|||||.|
  Fly  1986 IYFVIFIVCGSFFTLNLFIGVIIDNFNMLKKKYEGGVLEMFLTESQKHYYTAMKKLGRKKPQKVI 2050

Mouse  1347 PRPLNKCQAFVFDLVTSQVFDVIILGLIVTNMIIMMAESEGQPNEVKKIFDILNIVFVVIFTVEC 1411
            .||:|...|..:||..|:.|::.|..||..||:.|..|...||:.|..|.::.|..|..:|.:|.
  Fly  2051 KRPINHFLAMFYDLSNSRRFEIAIFVLIFLNMLTMGIEHYDQPHAVFFILEVSNAFFTTVFGLEA 2115

Mouse  1412 LIKVFALRQHYFTNGWNLFDCVVVVLSIISTLVSGLENSNVFPPTLFRIVRLARIGRILRLVRAA 1476
            ::|:..||.||||..||:||.::|:.||...|:..:.......|||.|:||:.||||||||::||
  Fly  2116 IVKIVGLRYHYFTVPWNVFDFLLVLASIFGILMEDIMIDLPISPTLLRVVRVFRIGRILRLIKAA 2180

Mouse  1477 RGIRTLLFALMMSLPSLFNIGLLLFLVMFIYAIFGMNWFSKVKRGSGIDDIFNFDTFSGSMLCLF 1541
            :|||.|||||::|||:|||||.||.|:.|||||.||:.|..||....:||:.||.||..||..||
  Fly  2181 KGIRKLLFALVVSLPALFNIGALLGLITFIYAILGMSLFGNVKLQGALDDMVNFQTFGRSMQLLF 2245

Mouse  1542 QITTSAGWDALLNPMLESKASC----NSSSQESCQQPQIAIVYFVSYIIISFLIVVNMYIAVILE 1602
            ::.|||||:.:|..::.....|    :..:..:|..|.:||.||.|:||||::||:|||||:|||
  Fly  2246 RLMTSAGWNDVLESLMIQPPDCDPFIHGHTNGNCGHPLLAITYFTSFIIISYMIVINMYIAIILE 2310

Mouse  1603 NFNTATEESEDPLGEDDFEIFYEIWEKFDPEATQFIQYSSLSDFADALPEPLRVAKPNRFQFLMM 1667
            |||.|.:|.|..:.|||.|:||..|.|:||.|||||.:|.||||..:|..||.::|||....:..
  Fly  2311 NFNQAHQEEEIGIVEDDLEMFYIRWSKYDPHATQFIHFSQLSDFIASLDPPLGISKPNNVALVSF 2375

Mouse  1668 DLPMVMGDRLHCMDVLFAFTTRVLGNSSGLDTMKAMMEE---KFMEANPFKKLYEPIVTTTKRKE 1729
            :||:..|:::||:|:|.|....|||:....|..|.:.|:   ||.:..|.:|..|.:.:|...|.
  Fly  2376 NLPISKGNKIHCLDILHALVKHVLGHVEETDNFKQLQEQMDVKFKKQFPTRKELEIVSSTRIWKR 2440

Mouse  1730 EEECAAVIQRAYRRHMEKMIKLKLKGRSSSSLQVFCNG----DLSSLDVPKIKV 1779
            :|:.|..||..::.::.:..:.:......|:.|....|    .||:|:...::|
  Fly  2441 QEKAAKTIQTGWKEYLRRKREKERSNSGDSATQTSSPGGWQSKLSALNFFHLQV 2494

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Scn11aXP_017168851.1 Ion_trans 145..424 CDD:366146 127/289 (44%)
Ion_trans 591..825 CDD:366146 119/267 (45%)
Na_trans_assoc 830..1047 CDD:368948 76/761 (10%)
Ion_trans 1051..1315 CDD:366146 149/268 (56%)
Na_channel_gate 1307..1359 CDD:240441 30/53 (57%)
Ion_trans 1363..1612 CDD:366146 120/252 (48%)
GPHH 1623..1670 CDD:374878 22/46 (48%)
NaCP60ENP_001261172.1 Ion_trans 152..371 CDD:278921 100/222 (45%)
Ion_trans 705..902 CDD:278921 93/199 (47%)
Ion_trans 1768..2019 CDD:278921 145/252 (58%)
Na_channel_gate 2009..2063 CDD:240441 30/53 (57%)
Ion_trans 2085..2320 CDD:278921 113/234 (48%)
GPHH 2331..2386 CDD:293510 25/54 (46%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D37221at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100419
Panther 1 1.100 - - O PTHR10037
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
65.820

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