DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ABCA4 and Eato

DIOPT Version :9

Sequence 1:NP_000341.2 Gene:ABCA4 / 24 HGNCID:34 Length:2273 Species:Homo sapiens
Sequence 2:NP_001036360.1 Gene:Eato / 34783 FlyBaseID:FBgn0028539 Length:1597 Species:Drosophila melanogaster


Alignment Length:1760 Identity:459/1760 - (26%)
Similarity:733/1760 - (41%) Gaps:431/1760 - (24%)


- Green bases have known domain annotations that are detailed below.


Human   598 VEDFRYIWGGFAYLQDMVEQGITRSQVQAEAPVGIYLQQMPYPCFVD-DSFMIIL--NRCFPIFM 659
            ::|..||..||..||.::::...:.| :......:.:..||....:. ||..:..  ..|..:|.
  Fly   169 IDDDDYIRSGFLSLQHILDKQYMKYQ-ELGKDFEVVVSSMPNMEVISMDSHRLTYFGTLCSILFN 232

Human   660 VLAWIYSVSMTVKSIVLEKELRLKETLKNQGVSNAVIWCTWFLDSFSIMSMSIFLLTIFIMHGRI 724
            |:.    :|..|...|.||:..|||.|......:.:...|:||..|    :...||.||::....
  Fly   233 VVL----LSSFVVPFVEEKQNGLKEFLNLVTPMSFLNGLTFFLIRF----VCYTLLMIFVLVVAY 289

Human   725 LHYSDPFILFLFLLAFSTATIMLCFLLSTFFSKASLAAACSGVIYFT-------LYLPHILCF-- 780
            |:.:...|.|.::     |.:.|.::||| .|.|.|.:.|...:::.       |.:|:...|  
  Fly   290 LYKALGSICFAYV-----AVLFLLYILST-MSYAYLISICFHSVFYAKIGGLAMLIIPYAFSFVR 348

Human   781 AWQDRMTAELKKAVSLLSPVAFGFGTEYLVRFEEQGLGLQWSNI-------GNSPTEGDEFSFLL 838
            :|...:      |....|...|..|.:....|..:....::..:       .||.|       :.
  Fly   349 SWATSL------AFVCFSTNTFLEGLDIFQTFSNKRKNREFGAVDVFRVIKSNSST-------MF 400

Human   839 SMQMMLL-DAAVYGLLAWYLDQVFPGDYGTPLPWYFLLQESYWLGGEGCSTREERALEKTEPLTE 902
            |:.::|: .:.:|.:|..||..||||..|...|.:|.|.                  .||....:
  Fly   401 SVYVVLVFQSFLYAMLYNYLGCVFPGPGGLKRPMFFFLD------------------PKTYMKRQ 447

Human   903 ETEDPEHPEGIHDSFFEREHPGWVPGVCVKNLVKIFEPCGRPAV--DRLNITFYENQITAFLGHN 965
            ..|....|.|.|             .:.:..|.|.|:...|..:  |.||:|....:||..||||
  Fly   448 RNEYTTTPRGTH-------------AIIITELCKKFQTSKRDTLISDNLNMTINNKEITVLLGHN 499

Human   966 GAGKTTTLSILTGLLPPTSGTVLV-GGRDIETSLDAVRQSLGMCPQHNILFHHLTVAEHMLFYAQ 1029
            ||||||.::::.||:|..||.::| ..||:.    :.|..:|.||||::...::|..:|:.|:||
  Fly   500 GAGKTTMMNMIMGLVPKDSGKIIVCSERDVA----SYRHLIGFCPQHSVFMSYMTCHQHLEFFAQ 560

Human  1030 LKGKSQEEAQLEMEAMLEDTGLHHKRNEEAQDLSGGMQRKLSVAIAFVGDAKVVILDEPTSGVDP 1094
            |:|..:.:|:...:..|:..||..||||..::|||||:|:||:.||..|:.|:||||||:||:|.
  Fly   561 LRGACRSDARDWADEKLKKLGLSDKRNEFGKNLSGGMKRRLSLGIAIAGNTKIVILDEPSSGLDI 625

Human  1095 YSRRSIWDLLLKYRSGRTIIMSTHHMDEADLLGDRIAIIAQGRLYCSGTPLFLKNCFGTGLYLTL 1159
            .|||.:||:||..|..:.::::||:|:||::|||.|.|:|.|:|...|:||.||...|.|..|.|
  Fly   626 NSRRELWDILLNLRKEKAVLVTTHYMEEAEVLGDTICILANGKLQSIGSPLELKRKSGIGYRLKL 690

Human  1160 VRKMKNIQSQRKGSEGTCSCSSKGFSTTCPAHVDDLTPEQVLDGDVNELMDVVLHHVPEAKLVEC 1224
                                           .::|.|..:|      |:|:::.|.||.|:::..
  Fly   691 -------------------------------EINDFTSREV------EIMEIIHHFVPTARVLNV 718

Human  1225 IGQELIFLLP--NKNFKHRAYASLFRELEETLADLGLSSFGISDTPLEEIFLKVTEDSDSGPLFA 1287
            :...:...||  .||    .:|.:...||....:||:.:..::||.||::||:            
  Fly   719 VNPTVYICLPYAYKN----CFAQMLYRLETESKELGIHTISMTDTSLEDVFLR------------ 767

Human  1288 GGAQQKRENVNPRHPCLGPREKAGQTPQDSNVCSPGAPAAH---PEGQPPPEPECPGPQLNTGTQ 1349
                           |.|.:::. .||..|...:|  ..||   .:..||          :.|  
  Fly   768 ---------------CAGEQDQV-DTPDGSRNDAP--LLAHYKRLQDHPP----------HRG-- 802

Human  1350 LVLQHVQALLVKRFQHTIRSHKDFLAQIVLPATFVFLALMLSIVIPPFGEYPALTLHPWIYGQQY 1414
             :.|...|:..|::..........|..:.:|...||.|:::...:.......||.|         
  Fly   803 -LFQLWMAVFYKKWTFISNEWLYTLIMLCIPFVCVFGAILVMHAMSLVENEEALPL--------- 857

Human  1415 TFFSMDEPGSEQFTVLADVLLNKPGFGNRCLKEGWLPEYPCGNSTPWKTPSVSPNITQLFQKQKW 1479
               .:.:.||....|                      ..|.|:..         ::.|..::|  
  Fly   858 ---KLSQMGSGVIYV----------------------HNPTGHHA---------HLEQQLRQQ-- 886

Human  1480 TQVNPSPSCRCSTREKLTMLPECPEGAGGLPPPQRTQRSTEILQ---DLTDRNISDFLVKTYPAL 1541
            .::|                       |........:.|.::..   ||...|::|||       
  Fly   887 IELN-----------------------GITAKTMHLRGSNDVKNESLDLQRDNLADFL------- 921

Human  1542 IRSSLKSKFWVNEQRYGGISIGGKLPVVPITGEALVGFLSDLGRIMNVSGGPITREASKEIPDFL 1606
                                            |.::|.:...|      ||    ..:.:.|   
  Fly   922 --------------------------------EQVIGIIDMYG------GG----RGTSDTP--- 941

Human  1607 KHLETEDNIKVWFNNKGWHALVSFLNVAHNAILRASLPKDRSPEEYGITVISQPLNLTKEQLSEI 1671
                   .|:::::...:|:.|..:|:..:|:|:...|:......|      .|:   :..:|:|
  Fly   942 -------TIEIFYSGNRYHSSVELINLVDSAMLKLGRPESEIDTTY------VPI---RRFVSDI 990

Human  1672 TVLTTSVDAVVAICVIFSMSFVPASFVLYLIQERVNKSKHLQFISGVSPTTYWVTNFLWDIMNYS 1736
            :.......||:   |...|.|....|:....:|..|..|.||.:|..   |||..:|.:|::   
  Fly   991 SPSRLEYYAVI---VPIGMFFFMFYFISLPFREYANGFKQLQTMSRF---TYWFAHFTFDML--- 1046

Human  1737 VSAGLVVGIF----IGFQKKAYTSPENLPALVALLLLYGWAVIPMMYPASFLFDVPST--AYVAL 1795
            :...:.|.:|    :....:.||:.| |..:|..:..||.:.:|::|.....|...||  .|:.|
  Fly  1047 ILIFVCVALFSLQSLMMPSELYTTAE-LKVIVLSIFFYGCSYLPILYALGNNFKSISTISTYLLL 1110

Human  1796 -----SCANLFIGINSSAITFILELFENNRTLL----RFN-----AVLRKLLIVFPHFCLGRGLI 1846
                 :.|.|....|::|    ::|.|.....|    .||     .::.:..|...|..|.:|||
  Fly  1111 MLIVSAIAPLITSSNAAA----MKLHETKIAFLCFLPDFNLNHQFRIINENFITRRHPALIKGLI 1171

Human  1847 DLALSQAVTDVYARFGEEHSANPFHWDLIGKNLFAMVVEGVVYFLLTLLVQRHFFLS-------- 1903
                ||.....||                       ...||:......:|..|.:|.        
  Fly  1172 ----SQDTFFAYA-----------------------TAVGVMVMAFFTIVLEHKYLRRRIHDGIW 1209

Human  1904 QWIAEPTK---------EPIVDEDDDVAEERQRIITGGNKTDILR---------LHELTKIYPGT 1950
            :|..:..|         .|| .|.||.|.|.:|:      ||:::         :|.|.|.|  .
  Fly  1210 EWAFQRKKYNSTGTLPSTPI-SEIDDCAREEKRV------TDLIKDPLNDHSLIVHNLRKRY--G 1265

Human  1951 SSPAVDRLCVGVRPGECFGLLGVNGAGKTTTFKMLTGDTTVTSGDATVAGKSILTNISEVHQNMG 2015
            ...|||.:......|||||||||||||||:||:|:..:..:..|...:.|..|..:..:..:..|
  Fly  1266 DKLAVDGVSFAAAQGECFGLLGVNGAGKTSTFQMIAANLPLDGGTIRIKGADIREHELKYREYFG 1330

Human  2016 YCPQFDAIDELLTGREHLYLYARLRGV-------PAEEIEKVANWSIKSLGLTVYADCLAGTYSG 2073
            ||||:||:::.:|..:.||..|.|||:       ||...|.|..| ::.:.||.|.......|||
  Fly  1331 YCPQYDALNKFMTAEQCLYYMALLRGLSRRRTDGPASCKEHVKYW-LEKMHLTKYQKVQVRHYSG 1394

Human  2074 GNKRKLSTAIALIGCPPLVLLDEPTTGMDPQARRMLWNVIVSIIREGRAVVLTSHSMEECEALCT 2138
            |.||||..|:|:||.|.||||||||||:||.:||.||..|.....:.|.||||||||:|||.||.
  Fly  1395 GTKRKLLAAMAMIGAPALVLLDEPTTGVDPISRRFLWQCIKDFQGKDRTVVLTSHSMDECEELCN 1459

Human  2139 RLAIMVKGAFRCMGTIQHLKSKFGDGYIVTMKIKSPKDDLLPDLNPVEQFFQGNFPGSVQRERHY 2203
            |||||..|.|:|:..|..||..  .|:.:.:|:|:..:..: :::.:....:..|||...||.|.
  Fly  1460 RLAIMAHGKFKCLNNICALKRL--SGFTIKLKMKADTETEM-NVSTITGTLKSEFPGLELRESHA 1521

Human  2204 NMLQFQVSS-------SSLARIFQLLLSHKDSLLIEEYSVTQTTLDQVFVNF---AKQQTESHDL 2258
            ..|.:.||:       ||:.:|.:..|..:.|.|:.:|||.:.||:.:|:.|   ||.|:.|...
  Fly  1522 GTLTYFVSTQESVVLWSSVFKIAEEYLGDRLSALVADYSVNECTLEDIFLKFEREAKSQSTSRQT 1586

Human  2259 PLHPR 2263
            .:..|
  Fly  1587 SVQRR 1591

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ABCA4NP_000341.2 rim_protein 1..2272 CDD:130324 459/1760 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 891..911 3/19 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1284..1345 10/63 (16%)
EatoNP_001036360.1 ABC2_membrane_3 <209..347 CDD:289468 36/151 (24%)
CcmA 460..767 CDD:224054 123/351 (35%)
ABC_subfamily_A 461..679 CDD:213230 94/221 (43%)
ABC2_membrane_3 <937..1117 CDD:289468 45/208 (22%)
ABC_subfamily_A 1255..1479 CDD:213230 103/226 (46%)
drrA 1262..1573 CDD:130256 127/316 (40%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165148370
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0059
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53524
OrthoDB 1 1.010 - - D131191at2759
OrthoFinder 1 1.000 - - FOG0000051
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100045
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
76.660

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