DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Slc26a4 and CG5404

DIOPT Version :9

Sequence 1:	NP_035997.1	Gene:	Slc26a4 / 23985	MGIID:	1346029	Length:	780	Species:	Mus musculus
Sequence 2:	NP_650482.1	Gene:	CG5404 / 41901	FlyBaseID:	FBgn0038354	Length:	627	Species:	Drosophila melanogaster

Alignment Length:	587	Identity:	150/587 - (25%)
Similarity:	252/587 - (42%)	Gaps:	149/587 - (25%)

- Green bases have known domain annotations that are detailed below.

Mouse    69 LPILDWLPKYRVKEWLLSDIISGVSTGLVGTLQGMAYALLAAVPVQFGLYSAFFPILTYFVFGTS 133
            :|:..|||.|.. ||.:.|.|:|::.||....:.||.||||.:|.::||.|||...|.|.|||:.
  Fly    49 VPVFQWLPLYST-EWGIDDFIAGITLGLTIIPESMACALLAGLPARYGLCSAFIGPLIYMVFGSI 112

Mouse   134 RHISVGPFPVVSLMVGSVVLSMAPDDHFLVPSGNGSALNSTTLDTGTRDAARVLLASTLTLLVGI 198
            ..:.:||..:|:|:  ||..::.....|                           |..||.|.||
  Fly   113 DKVIIGPTSLVALV--SVQFTVGRPIEF---------------------------AFLLTFLSGI 148

Mouse   199 IQLVFGGLQIGFIVRYLADPLVGGFTTAAAFQVLVSQLKIVLNV-----STKNYNGILSIIYTLI 258
            :|::.|.:::|||..:::.|::..|::|.|..|:.||||::|.:     ...|..|:||
  Fly   149 VQIIMGTMRMGFIFEFISMPVIKAFSSATAILVIESQLKVLLGIKYLVAGLMNSVGMLS------ 207

Mouse   259 EIFQNIGDTNIADFIAGLLTIIVCMAVKELNDRFKH------------------RIPVPIPIEVI 305
               ..|.::|:||.|.|:..|:..:.: ||.||..:                  |..:.:.|..|
  Fly   208 ---SRIEESNMADLIMGVCAIVFLLLL-ELLDRVANNEKRNKILRIFCRYLSTSRNTLIVLIAAI 268

Mouse   306 VTII--------ATAISYGA---------------NLEKNYNA-GIVKSIPSGFLPPVLPSVGLF 346
            |:.|        ..|:|..|               ..|:||:. .::|.:..|.:  |:|.||:.
  Fly   269 VSFIWIQKCGQVPYALSKNALSTLPNFTVPSFHIETAERNYSIWEVLKELNIGII--VIPIVGIL 331

Mouse   347 SDMLAASFSIAVVAYAIAVSVGKVYATKHDYVIDGNQEFIAFGISNVFSGFFSCFVATTALSRTA 411
            ::                :|:||:....   ::|.|||.:..|:.|:|........::.|.:|.|
  Fly   332 TN----------------ISIGKLTPKG---LVDTNQELLTVGLCNMFGSCVQAMPSSGAFTRYA 377

Mouse   412 VQESTGGKTQVAGLISAVIVMVAIVALGRLLEPLQKSVLAAVVIANLKGMFMQVCD--VP-RLWK 473
            :..:.|.:|.:|.|...:||::|:..|......:.::.|||::|.::    ..:.|  :| |||:
  Fly   378 ISTACGLRTPMANLYLGIIVLLALSYLSPYFNYIPEATLAAILICSI----FTLLDFKLPMRLWR 438

Mouse   474 QNKTDAVIWVFTCIMSIILGLDLGLLAG-------LLFALLTVVLRV---QFPSWNGLGSVPSTD 528
            .:|.|...|:....:|::.|:::||...       |||......:||   |......:...||..
  Fly   439 DSKRDFATWLLCFCVSVLFGVEVGLFVSIVVTALHLLFLWARPEIRVKIEQLDEMQYIRVTPSNG 503

Mouse   529 IYKSITHYKNLEEPEGVKILRFSSPIFYGNVDGFKKC----INSTVGFDAIRVYNKRLKALRRIQ 589
            ||....:|  |.|    ::|              |.|    ...||..|..|:......|.:.|.
  Fly   504 IYFPAINY--LRE----RVL--------------KACEQADFRITVVIDGQRISGMDYTAAQGIS 548

Mouse   590 KL 591
            ||
  Fly   549 KL 550

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Slc26a4	NP_035997.1	sulP	70..725	CDD:273284	150/586 (26%)
CG5404	NP_650482.1	sulP	50..557	CDD:273284	150/586 (26%)
CG5404	NP_650482.1	STAS_SulP_like_sulfate_transporter	498..>554	CDD:132913	18/73 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0659
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3293
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000041
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X49
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.760