DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tenm2 and Ten-m

DIOPT Version :9

Sequence 1:XP_006533350.1 Gene:Tenm2 / 23964 MGIID:1345184 Length:2774 Species:Mus musculus
Sequence 2:NP_001262211.1 Gene:Ten-m / 40464 FlyBaseID:FBgn0004449 Length:3349 Species:Drosophila melanogaster


Alignment Length:2969 Identity:931/2969 - (31%)
Similarity:1455/2969 - (49%) Gaps:435/2969 - (14%)


- Green bases have known domain annotations that are detailed below.


Mouse    41 SSSETL----KAYDHDSRMHYGNRVTDLVHRESDEFSRQGTNFTLAELGICEPSPHRSGYCSDMG 101
            |:::||    :.|||.:     .....:.|.|.:|...|......| :|:.......|...:...
  Fly   507 SAAKTLVNKRRKYDHGT-----VEAEHIKHEEEEEEDEQKLERHEA-IGMATELTTESETSTLPA 565

Mouse   102 IL---HQGYSLSTG--------SDADSDTEGGMSP-----------------EHAIRLWGRGIKS 138
            ::   :|..:.|:|        ||.|...|....|                 ||..:     ||.
  Fly   566 VIDDDNQSDNSSSGPTPETTVRSDTDDIVEINTPPSQTAQRTFAAVSHQPAIEHDFQ-----IKG 625

Mouse   139 RRSSGLSSRE------NSALTLTDS-DNENKSDDDNGRPIPPTSSSSLLPSAQLPSSHNPPPVSC 196
            ..:.||.:.:      |:...|.|: :.::|.....|.| |....|.....|.|.|      :..
  Fly   626 TDAGGLQTEKPATDDINNERDLADNYEVDSKEPTSPGTP-PQGKVSQQTGKASLQS------LQS 683

Mouse   197 QMPLLDSNTSH------------------QIMDTNPDEEFS----PNSYLLRA----CSGPQQAS 235
            :..|:.::.||                  :|..|...|..:    |:.::.|:    ..|.||..
  Fly   684 ESDLMMNDASHYEDIDIVKLDGLTISHEEEIYKTADKENMAPKNQPSQHIDRSQNEVLKGHQQGD 748

Mouse   236 SSGP-----------------------------PNHHSQSTLRPPLPP---PH--NHTLSHHHSS 266
            ...|                             ....|..||...:|.   ||  ...|:|...:
  Fly   749 EKQPQLEPLKPYVSERVDLPGKRIFLNLTIATDEGSDSVYTLHVEVPTGGGPHFIKEVLTHEKPT 813

Mouse   267 ANSLNRNSLTNRRSQIHAPAP----APNDLATTPESVQLQDSWVLNSNVPLETRHFLFKTSSGST 327
            |.:         .|.:..|.|    .|......|..:.|.|:..::|..|.:|    ..||:.|.
  Fly   814 AQA---------DSCVPEPPPRMPDCPCSCLPPPAPIYLDDTVDIDSAPPAKT----VTTSTISA 865

Mouse   328 PL---------------------FSSSSPGYPLTS----GTVYTPP-----------PRLLP--- 353
            |:                     .||::...|.|.    ...:|.|           |.::|   
  Fly   866 PINPFHSEEEDDEDGVRDEEQTPSSSTATNLPSTEIDNHIAAFTEPAVGAGGVPFACPDVMPVLI 930

Mouse   354 ---RNTFSRKAFKLKKPSKYCSWKCAALSAIAAALLLAILLAYFIAMHLLGLNWQLQPADGHTFN 415
               ..||..::|                                             |.||.|| 
  Fly   931 LEGARTFPARSF---------------------------------------------PPDGTTF- 949

Mouse   416 NGVRTGLPGNDDVATVPSGGKVPWSLKNSSIDSGEAEVGRRVTQEVPPGVFWRSQIHISQPQFLK 480
                                             |:..:|:::|:|:.|..:|..|.:.|:|.::|
  Fly   950 ---------------------------------GQITLGQKLTKEIQPYSYWNMQFYQSEPAYVK 981

Mouse   481 FNISLGKDALFGVYIRRGLPPSHAQYDFMERLDGKEKWSVVESPRERRSIQTLVQNEAVFVQYLD 545
            |:.::.:.|..|||.||...|:|.||.|.|.|.|     ...|.|..|:....:..|.  .:|::
  Fly   982 FDYTIPRGASIGVYGRRNALPTHTQYHFKEVLSG-----FSASTRTARAAHLSITREV--TRYME 1039

Mouse   546 VGLWHLAFYNDGKD-KEMVSFNTVVLDSVQDCPRNCHGNGECVSGLCHCFPGFLGADCAKAACPV 609
            .|.|.::.|||..| :|:..:..|..|..|:||..|.|||:|:.|.|.|.|||.|.||:::.|||
  Fly  1040 PGHWFVSLYNDDGDVQELTFYAAVAEDMTQNCPNGCSGNGQCLLGHCQCNPGFGGDDCSESVCPV 1104

Mouse   610 LCSGNGQYSKGTCQCYSGWKGAECDVPMNQCIDPSCGGHGSCIDGNCVCAAGYKGEHCEEVDCLD 674
            |||.:|:|:.|.|.|..||||.||.:..::|....|.|||.|:.|.|.|..||||:.||||||..
  Fly  1105 LCSQHGEYTNGECICNPGWKGKECSLRHDECEVADCSGHGHCVSGKCQCMRGYKGKFCEEVDCPH 1169

Mouse   675 PTCSSHGVCVNGECLCSPGWGGLNC---ELARVQCPDQCSGHGTYLPDSGLCSCDPNWMGPDCSV 736
            |.||.||.|.:|.|:|..||.|.:|   :...:||...||||||:..|:..|:|:..|.|.|||.
  Fly  1170 PNCSGHGFCADGTCICKKGWKGPDCATMDQDALQCLPDCSGHGTFDLDTQTCTCEAKWSGDDCSK 1234

Mouse   737 EVCSVDCGTHGVCIGGACRCEEGWTGAACDQRVCHPRCIEHGTCKDGKCECREGWNGEHCTIGRQ 801
            |:|.:|||.||.|.|.||.|:..|.|..|:.|:|..||.|||.||:|.|.|..||||:||||   
  Fly  1235 ELCDLDCGQHGRCEGDACACDPEWGGEYCNTRLCDVRCNEHGQCKNGTCLCVTGWNGKHCTI--- 1296

Mouse   802 TAGTETDGCPDLCNGNGRCTL-GQNSWQCVCQTGWRGPGCNVAMETSCADNKDNEGDGLVDCLDP 865
                  :|||:.|.|:|:|.: |:..|:|.|..||.||.|.:|:|.:|.|:|||:.||||||.||
  Fly  1297 ------EGCPNSCAGHGQCRVSGEGQWECRCYEGWDGPDCGIALELNCGDSKDNDKDGLVDCEDP 1355

Mouse   866 DCCLQSACQNSLLCRGSRDPLDIIQQGQTDWPAV-KSFYDRIKLLAGKDSTHIIPG--------- 920
            :||....|:.|.||..:..|:|::.:.|.  ||: .||::|:|.|..:.|......         
  Fly  1356 ECCASHVCKTSQLCVSAPKPIDVLLRKQP--PAITASFFERMKFLIDESSLQNYAKLETFNESIF 1418

Mouse   921 DNPFNSSLVSLIRGQVVTMDGTPLVGVNVSFVKYPKYGYTITRQDGTFDLIANGGSALTLHFERA 985
            .|.||:|..::|||:|||..|..||||.||.....: |:|:||.||.|||:.|||.|:||.|.||
  Fly  1419 WNYFNASRSAVIRGRVVTSLGMGLVGVRVSTTTLLE-GFTLTRDDGWFDLMVNGGGAVTLQFGRA 1482

Mouse   986 PFMSQERTVWLPWNSFYAMDTLVMK-TEENSIP-----SCDLSGFVRPDPIIISSPLSTFFSASP 1044
            ||..|.|.|.:|||....:|.:||. :||..:.     :|....:....|::::|....|..|.|
  Fly  1483 PFRPQSRIVQVPWNEVVIIDLVVMSMSEEKGLAVTTTHTCFAHDYDLMKPVVLASWKHGFQGACP 1547

Mouse  1045 ASNPIVPETQVLHEEIELPGTNVKLRYLSSRTAGYKSLLKITMTQSTVPLNLIRVHLMVAVEGHL 1109
            ..:.|:.|:||:.|.:::|||.:.|.|.|||.|||.|.:|:.:|...:|.:|..:||.:.:||.|
  Fly  1548 DRSAILAESQVIQESLQIPGTGLNLVYHSSRAAGYLSTIKLQLTPDVIPTSLHLIHLRITIEGIL 1612

Mouse  1110 FQKSFQASPNLAYTFIWDKTDAYGQRVYGLSDAVVSVGFEYETCPSLILWEKRTALLQGFELDPS 1174
            |::.|:|.|.:.:|:.|::.:.|.|||||::.|||.||::|..|.. |:|:.:|..|.|.::..|
  Fly  1613 FERIFEADPGIKFTYAWNRLNIYRQRVYGVTTAVVKVGYQYTDCTD-IVWDIQTTKLSGHDMSIS 1676

Mouse  1175 NLGGWSLDKHHTLNVKSGILHKGTGENQFLTQQPAIITSIMGNGRRRSISCPSCNGLAEGNKLLA 1239
            .:|||:||.||..|...|||.||.|.|.:|..:|.||.:.||:|.:|.:.||.|:|.|...:|||
  Fly  1677 EVGGWNLDIHHRYNFHEGILQKGDGSNIYLRNKPRIILTTMGDGHQRPLECPDCDGQATKQRLLA 1741

Mouse  1240 PVALAVGIDGSLFVGDFNYIRRIFPSRNVTSILELRNKEFKHSNSPGHKYYLAVDPVTGSLYVSD 1304
            |||||...|||||||||||||||....::.::::|      ::....::|::|:.|:.|:|||||
  Fly  1742 PVALAAAPDGSLFVGDFNYIRRIMTDGSIRTVVKL------NATRVSYRYHMALSPLDGTLYVSD 1800

Mouse  1305 TNSRRIYRVKSLSGAKDLAGNSEVVAGTGEQCLPFDEARCGDGGKAVDATLMSPRGIAVDKNGLM 1369
            ..|.:|.||:..:.......|.|.|.|:||:|||.|||.||||..|.||.|..|:|||:..:.::
  Fly  1801 PESHQIIRVRDTNDYSQPELNWEAVVGSGERCLPGDEAHCGDGALAKDAKLAYPKGIAISSDNIL 1865

Mouse  1370 YFVDATMIRKVDQNGIISTLLGSN-DLTAVRPLSCDSSMDVAQVRLEWPTDLAVNPMDNSLYVLE 1433
            ||.|.|.||.||::||:|||:|:: ..:..:|:.|:.::.:.::.|.|||:|||:||||:|::::
  Fly  1866 YFADGTNIRMVDRDGIVSTLIGNHMHKSHWKPIPCEGTLKLEEMHLRWPTELAVSPMDNTLHIID 1930

Mouse  1434 NNVILRITENHQVSIIAGRPMHCQVPGIDYSLSKLAIHSALESASAIAISHTGVLYITETDEKKI 1498
            :::|||:|.:.:|.:|:|||:||......|. :.||.|:.|....:||....|.||:.|:|.::|
  Fly  1931 DHMILRMTPDGRVRVISGRPLHCATASTAYD-TDLATHATLVMPQSIAFGPLGELYVAESDSQRI 1994

Mouse  1499 NRLRQVTTNGEICLLAGAASDCDCKNDVNCICYSGDDAYATDAILNSPSSLAVAPDGTIYIADLG 1563
            ||:|.:.|:|.|...|||.|.|:|. :..|.|:..:...||.|..|:.::|||.||..::|||..
  Fly  1995 NRVRVIGTDGRIAPFAGAESKCNCL-ERGCDCFEAEHYLATSAKFNTIAALAVTPDSHVHIADQA 2058

Mouse  1564 NIRIRAVSKNKPVLNAFNQYEAASPGEQELYVFNADGIHQYTVSLVTGEYLYNFTY---SADNDV 1625
            |.|||:|..:.|..:...:||..:|..||:|:||..|.|..|.:::|||..|.|||   :::..:
  Fly  2059 NYRIRSVMSSIPEASPSREYEIYAPDMQEIYIFNRFGQHVSTRNILTGETTYVFTYNVNTSNGKL 2123

Mouse  1626 TELIDNNGNSLKIRRDSSGMPRHLLMPDNQIITLTVGTNGGLKAVSTQNLELGLMTYDGNTGLLA 1690
            :.:.|..||.:.:.||.:.....:.....|...|.:.....|..:||.:.......|.|.||||.
  Fly  2124 STVTDAAGNKVFLLRDYTSQVNSIENTKGQKCRLRMTRMKMLHELSTPDNYNVTYEYHGPTGLLR 2188

Mouse  1691 TKSDETGWTTFYDYDHEGRLTNVTRPTGVVTSLHREME-KSITIDI-ENSNRD-----DDVTVIT 1748
            ||.|.||.:..|:||..||||:...|||.|..|..::. |...:.: ||:.::     ...|||.
  Fly  2189 TKLDSTGRSYVYNYDEFGRLTSAVTPTGRVIELSFDLSVKGAQVKVSENAQKEMSLLIQGATVIV 2253

Mouse  1749 NLSSVEASYTVVQDQVRNSYQLCNNGTLRVMYANGMAVSFHSEPHVLAGTITPTIGRCNISLPME 1813
            ...:.|:..||..|           |:...:...|..:.....|:.:....:|.:|.   |.|:.
  Fly  2254 RNGAAESRTTVDMD-----------GSTTSITPWGHNLQMEVAPYTILAEQSPLLGE---SYPVP 2304

Mouse  1814 ---------NGLNSIEWR--LRKE-------QIKG---KVTIFGRKLRVHGRNLLSIDYDRNIRT 1857
                     :..|..|||  :|::       |.||   .||..||||||:|.|:|:::|||..::
  Fly  2305 AKQRTEIAGDLANRFEWRYFVRRQQPLQAGKQSKGPPRPVTEVGRKLRVNGDNVLTLEYDRETQS 2369

Mouse  1858 EKIYDDHRKFTLRIIYDQVGRPFLWLPSSG-LAAVNVSYFFNGRLAGLQRGAMSERTDIDKQGRI 1921
            ..:..|.::..|.:.||:..||..:.|.|| .|.|::.|...|||...:.|.:.|....|:.||:
  Fly  2370 VVVMVDDKQELLNVTYDRTSRPISFRPQSGDYADVDLEYDRFGRLVSWKWGVLQEAYSFDRNGRL 2434

Mouse  1922 VSRMFADGKVWSYSYLDK--SMVLLLQSQRQ--YIFEYDSSDRLHAVTMPSVARHSMSTHTSIGY 1982
            ....:.||....|::.|.  |:.|.:.:.|:  |:.:||.:..|.::|.|....|:.|..||:|:
  Fly  2435 NEIKYGDGSTMVYAFKDMFGSLPLKVTTPRRSDYLLQYDDAGALQSLTTPRGHIHAFSLQTSLGF 2499

Mouse  1983 IRNIYNPPESNASVIFDYSDDGRILKTSFLGTGRQVFYKYGKLSKLSEIVYDSTAVTFGYDETTG 2047
            .:..|..|.:.......|:|:|:||.........:|.:.:....:|..|:...::..:.|.:||.
  Fly  2500 FKYQYYSPINRHPFEILYNDEGQILAKIHPHQSGKVAFVHDTAGRLETILAGLSSTHYTYQDTTS 2564

Mouse  2048 VLKMVNLQSGGFSCTIRYR-KVGPLVDKQIYRFSEEGMINARFDYTYHDNSFRIASIKPVISETP 2111
            ::|.|.:|..||.....:: ..|.|.|:::...|:..:.:||:.|.| |.:.|::.|:..|.:..
  Fly  2565 LVKSVEVQEPGFELRREFKYHAGILKDEKLRFGSKNSLASARYKYAY-DGNARLSGIEMAIDDKE 2628

Mouse  2112 LPVDLYRYDEISGKVEHFGKFGVIYYDI----NQIITTAVMTLSKHF------DTHGRIKEVQYE 2166
            ||...|:|.:..|::|       :..|:    |....|.:...:|.|      |.|||:|.|...
  Fly  2629 LPTTRYKYSQNLGQLE-------VVQDLKITRNAFNRTVIQDSAKQFFAIVDYDQHGRVKSVLMN 2686

Mouse  2167 MFRSLMYWMTVQYDSMGRVIKRELKLGPYANTTKYTYDYDGDGQLQSVAVNDRPTWRYSYDLNGN 2231
            :....::.:.:.||...|:..::...|......|..|:.||    ..|.|.....|:|.:|.|||
  Fly  2687 VKNIDVFRLELDYDLRNRIKSQKTTFGRSTAFDKINYNADG----HVVEVLGTNNWKYLFDENGN 2747

Mouse  2232 -LHLLNPGNSARLMPLRYDLRDRITRLGDVQY-KIDDDGYLCQRGSDIFEYNSKGLLTRAYNKA- 2293
             :.:::.|..   ..|.||:.||:.::|||:: ..|..|::.:||...:.||::|.|..::.:. 
  Fly  2748 TVGVVDQGEK---FNLGYDIGDRVIKVGDVEFNNYDARGFVVKRGEQKYRYNNRGQLIHSFERER 2809

Mouse  2294 -SGWSVQYRYDGVGRRASYKTNLGHHLQYFYSDLHNPTRITHVYNHSNSEITSLYYDLQGHLFAM 2357
             ..|   |.||...|..::..|.|:..||:|::...|..:|||:....|....|:||.:..|.|:
  Fly  2810 FQSW---YYYDDRSRLVAWHDNKGNTTQYYYANPRTPHLVTHVHFPKISRTMKLFYDDRDMLIAL 2871

Mouse  2358 ESSSGEEYYVASDNTGTPLAVFSINGLMIKQLQYTAYGEIYYDSNPDFQMVIGFHGGLYDPLTKL 2422
            |... :.||||:|..|:|||.|..||.::|:::.|.:|.|..|:.|:|.:.|.|||||.||.|||
  Fly  2872 EHED-QRYYVATDQNGSPLAFFDQNGSIVKEMKRTPFGRIIKDTKPEFFVPIDFHGGLIDPHTKL 2935

Mouse  2423 VHFTQRDYDVLAGRWTSPDYTMWRNVGKE---PAPFNLYMFKNNNPLSNELDLKNYVTDVKSWLV 2484
            |:..||.||...|:|.:|   :|..:..|   |....:|.:.||:|: |....:||:.|:.|||.
  Fly  2936 VYTEQRQYDPHVGQWMTP---LWETLATEMSHPTDVFIYRYHNNDPI-NPNKPQNYMIDLDSWLQ 2996

Mouse  2485 MFGFQLSNIIPGFPRAKMYFVPPPYELSESQASENGQLITGVQQTTERHNQAF----------LA 2539
            :||:.|:|:..........:.|.....|.:.|.:.| :|:|::...|:.::.|          |.
  Fly  2997 LFGYDLNNMQSSRYTKLAQYTPQASIKSNTLAPDFG-VISGLECIVEKTSEKFSDFDFVPKPLLK 3060

Mouse  2540 LEGQVITKKLHASIREKAGHWFATTTPIIGKGIMFAIKEGR----VTTGVSSIASEDSRKVASVL 2600
            :|.::  :.|...:..:.|        :.|:|::.:...||    |..|.:|:..:   .|:||.
  Fly  3061 MEPKM--RNLLPRVSYRRG--------VFGEGVLLSRIGGRALVSVVDGSNSVVQD---VVSSVF 3112

Mouse  2601 NNAYYLDKMHYSIEGKDTHYFVKIGAADGDLVTLGTTIGRKVLESGVNVTVSQPTLLVNGRTRRF 2665
            ||:|:|| :|:||..:|..||||      |.|........::...|....:|...:..:|.:.. 
  Fly  3113 NNSYFLD-LHFSIHDQDVFYFVK------DNVLKLRDDNEELRRLGGMFNISTHEISDHGGSAA- 3169

Mouse  2666 TNIEFQYSTLLLSIRYGLTPDTLDEEKARVLDQARQRALGTAWAKEQQKARDGREGSRLWTEGEK 2730
            ..:.......::.|:||:.|   ::|:.|:|..|.:||:..||..|:|....|.:|...|||.||
  Fly  3170 KELRLHGPDAVVIIKYGVDP---EQERHRILKHAHKRAVERAWELEKQLVAAGFQGRGDWTEEEK 3231

Mouse  2731 QQLLSTGRVQGYEGYYVLPVEQYPELADSSSNIQFLRQNEMGKR 2774
            ::|:..|.|.|:.|..:..:.:||:|||...|:.|.|..:..:|
  Fly  3232 EELVQHGDVDGWNGIDIHSIHKYPQLADDPGNVAFQRDAKRKRR 3275

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Tenm2XP_006533350.1 Ten_N 10..374 CDD:399476 84/477 (18%)
exchanger_TraA <570..885 CDD:411343 155/318 (49%)
NHL 1240..1570 CDD:302697 140/330 (42%)
NHL repeat 1240..1279 CDD:271320 21/38 (55%)
NHL repeat 1291..1334 CDD:271320 16/42 (38%)
NHL repeat 1358..1396 CDD:271320 18/38 (47%)
NHL repeat 1412..1453 CDD:271320 19/40 (48%)
NHL repeat 1476..1509 CDD:271320 12/32 (38%)
NHL <1543..>1634 CDD:302697 34/93 (37%)
NHL repeat 1544..1570 CDD:271320 13/25 (52%)
NHL repeat 1546..1584 CDD:271320 14/37 (38%)
RhsA 1689..2482 CDD:225750 245/843 (29%)
Rhs_assc_core 2391..2468 CDD:274730 32/79 (41%)
Tox-GHH 2690..2767 CDD:406145 29/76 (38%)
Ten-mNP_001262211.1 TNFRSF 1069..1198 CDD:304602 66/128 (52%)
CRD2 1106..1151 CDD:276900 20/44 (45%)
EGF_2 1139..1162 CDD:285248 12/22 (55%)
Keratin_B2 1162..1330 CDD:279797 85/176 (48%)
EGF_2 1167..1194 CDD:285248 13/26 (50%)
DUF3844 1171..>1235 CDD:289707 28/63 (44%)
EGF_2 <1272..1294 CDD:285248 13/21 (62%)
NHL 1750..2065 CDD:302697 135/322 (42%)
NHL repeat 1784..1830 CDD:271320 17/45 (38%)
NHL repeat 1854..1888 CDD:271320 17/33 (52%)
NHL repeat 1911..1950 CDD:271320 19/38 (50%)
NHL repeat 1972..2005 CDD:271320 12/32 (38%)
NHL repeat 2039..2065 CDD:271320 13/25 (52%)
RHS_repeat 2183..2218 CDD:283287 19/34 (56%)
RhsA 2347..3020 CDD:225750 208/695 (30%)
YD_repeat_2x 2795..2836 CDD:273728 12/43 (28%)
Rhs_assc_core 2905..2980 CDD:274730 32/78 (41%)
Tox-GHH 3193..3268 CDD:292269 28/74 (38%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167837862
Domainoid 1 1.000 72 1.000 Domainoid score I9274
eggNOG 1 0.900 - - E1_KOG1225
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H22672
Inparanoid 1 1.050 1463 1.000 Inparanoid score I112
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG52630
OrthoDB 1 1.010 - - D5817at33208
OrthoFinder 1 1.000 - - FOG0000741
OrthoInspector 1 1.000 - - otm43347
orthoMCL 1 0.900 - - OOG6_100953
Panther 1 1.100 - - O PTHR11219
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X442
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1514.770

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