DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mapk7 and Drak

DIOPT Version :9

Sequence 1:NP_001277963.1 Gene:Mapk7 / 23939 MGIID:1346347 Length:806 Species:Mus musculus
Sequence 2:NP_001162723.1 Gene:Drak / 32097 FlyBaseID:FBgn0052666 Length:674 Species:Drosophila melanogaster


Alignment Length:675 Identity:143/675 - (21%)
Similarity:235/675 - (34%) Gaps:200/675 - (29%)


- Green bases have known domain annotations that are detailed below.


Mouse    50 DVGDEYEIIET-IGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKH-- 111
            |:.:.||:.:| ...|.:..|..|..:.||...|.|.:          ||..|.....|..||  
  Fly    31 DINEIYEVEQTPFARGKFAAVRRAIHKNTGSHFAAKFL----------KRRRRAQSSDKEIKHEI 85

Mouse   112 ---------DNIIAIKDILKPTVPYGEFRS-VYVVLDLME-SDLHQIIHSSQPLTLEHVRYFLYQ 165
                     |||:.:..:       .|.|| ..::|:|.. .:|..|:.:.:.||....|:.:.:
  Fly    86 AVLMLCEGEDNIVNLNAV-------HETRSDTALLLELATGGELQTILDNEECLTEAQARHCMRE 143

Mouse   166 LLRGLKYMHSAQVIHRDLKPSN-LLVNENCE--LKIGDFGMARGLCTSPAEHQYFMTEYVATRWY 227
            :|:.||::|...:.|.||||.| ||..|..|  ||:.|||::|.:|..     ..:.|...|..|
  Fly   144 VLKALKFLHDRSIAHLDLKPQNILLAGERIEDGLKLCDFGISRVVCEG-----INVREMAGTPDY 203

Mouse   228 RAPELM----LSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQ-LQLIMMVLGTPSPAVIQ 287
            .|||::    |||     ..|:||||.:...:|:....|.|...... |.:....|..|      
  Fly   204 VAPEVLQYEPLSL-----LTDIWSVGVLTYVLLSGFSPFGGDTKQETFLNISQCALTFP------ 257

Mouse   288 AVGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFLAKYHD 352
                                  :.::.|....|:..:.|.||.:|:.|::|...|.|.:|     
  Fly   258 ----------------------DNLFGGVSPVAIDFIRRALRIKPNDRMNATGCLDHIWL----- 295

Mouse   353 PDDEPDCAPPFDFAFDREALTRERIKEAIVAEIEDFHARREGIRQQIRFQPSLQPVASEPVCPDV 417
               :.||:.........::...|..:|.:..::||     |...:|:.        ..|....:|
  Fly   296 ---KDDCSLDRQIYLQPQSDAEEEEEEDVDDDVED-----EEEEEQVE--------EEEEETQNV 344

Mouse   418 EMPSPWAP-------------------------------SGDCAMESPPPALPPCSDPAPDTVDL 451
            |.|:..||                               ||....:.|.......|.|:.:|...
  Fly   345 EEPTTEAPQQQQQPVQQHQLAKSGQIHSKPTHNGHHRANSGGSISKIPIATSKLQSTPSSETTTA 409

Mouse   452 --TL---------QPAPPASELAPPKREGAISD--NTKAA-----------------LKAALLKS 486
              ||         :|    :::..|.|..:.||  ||..|                 ::.|.:.:
  Fly   410 IHTLTSNSNGHVHKP----TQIVTPTRRASDSDKENTYTATFVKKPVATIQLGSSNGIEDATVVA 470

Mouse   487 LRSRLRDGPSAPL--------EAPEPRKPVTAQERQREREEK----------------------- 520
            ..:...|.|:.|.        |:......|.|..::.:.|:.                       
  Fly   471 TLTLFPDAPTTPKVIRKTPTGESNGSATSVKALVKKFQLEDSSGSAVARRSGGAVTSSSGLHSPT 535

Mouse   521 ----RRRRQERAKEREKRRQERERKERGAGTLGGPSTDPLAGLVLSDNDRSLLERWTRMARPPAP 581
                |.....||.|......:::..:.|..:...||:.|.:....|.:..:||....|:....||
  Fly   536 TTSVRLNSIRRASEPLTTVYKKQTSQNGCSSTSNPSSSPGSSPTTSGSTATLLIHSQRLGNSTAP 600

Mouse   582 AP--APAPAPAPAPSSAQPTSTPTG 604
            |.  ...||.|.|.|||..:::.:|
  Fly   601 ASHCVAVPATATATSSASSSNSSSG 625

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mapk7NP_001277963.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..23
Required for cytoplasmic targeting 2..77 7/27 (26%)
STKc_ERK5 49..384 CDD:270842 86/355 (24%)
Required for binding to MAP2K5 78..139 16/72 (22%)
Necessary for oligomerization 140..406 65/274 (24%)
TXY 219..221 0/1 (0%)
May not be required for kinase activity, required to stimulate MEF2C activity 407..806 53/296 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 424..473 13/90 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 488..727 30/154 (19%)
Nuclear localization signal 505..539 7/60 (12%)
DrakNP_001162723.1 STKc_DRAK 28..295 CDD:271008 81/318 (25%)
S_TKc 45..295 CDD:214567 77/304 (25%)
PHA03255 379..>554 CDD:165513 28/178 (16%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
00.000

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