DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Lamc3 and LanA

DIOPT Version :9

Sequence 1:NP_035966.2 Gene:Lamc3 / 23928 MGIID:1344394 Length:1581 Species:Mus musculus
Sequence 2:NP_476617.1 Gene:LanA / 38723 FlyBaseID:FBgn0002526 Length:3712 Species:Drosophila melanogaster


Alignment Length:2740 Identity:521/2740 - (19%)
Similarity:792/2740 - (28%) Gaps:1308/2740 - (47%)


- Green bases have known domain annotations that are detailed below.


Mouse    46 PEFENAAFGRRAEASHTCGRP---PEDFCPHVGAPG----------AGLQCQRCDDADPGRRHDA 97
            |.:.|.|.||:..|:.|||:.   ||.:|..|||..          .|..|..||...|.|.|..
  Fly    26 PPYFNLATGRKIYATATCGQDTDGPELYCKLVGANTEHDHIDYSVIQGQVCDYCDPTVPERNHPP 90

Mouse    98 SYLTDFHSPDDSTWWQSPSMAFGVQYPTSVNLTLSLGKAYEITYVRLKFHTS-RPESFAIYKRTY 161
            ....|    ....|||||.::.|::: ..||||::..:.:.:.|:.::...| ||..:.:.|.|.
  Fly    91 ENAID----GTEAWWQSPPLSRGMKF-NEVNLTINFEQEFHVAYLFIRMGNSPRPGLWTLEKSTD 150

Mouse   162 ASGPWEPYQYYS---ASCQKTYGRPEGHYLRPGEDERVAFCTSEFSDISPLNGGNVAFSTLEGRP 223
            ....|.|:|::|   |.|:..:|:.....:...:|   ..||:|:|.|.||..|.:....|..||
  Fly   151 YGKTWTPWQHFSDTPADCETYFGKDTYKPITRDDD---VICTTEYSKIVPLENGEIPVMLLNERP 212

Mouse   224 SAYNFEESPVLQEWVTSTDILISLDRLNTFGDDIF----KDPRVLQSYYYAVSDFSVGGRCKCNG 284
            |:.|:..|.|||||..:|::.|.|.|.......:.    :||.|.:.|:|::.|.|:||||.|||
  Fly   213 SSTNYFNSTVLQEWTRATNVRIRLLRTKNLLGHLMSVARQDPTVTRRYFYSIKDISIGGRCMCNG 277

Mouse   285 HASEC---EPNAAGQ-LACRCQHNTTGVDCERCLPFFQDRPWARGTAEDANECLPCNCSGHSEEC 345
            ||..|   :|.:..: |||||||:|.|:.|..|.|.|:.:.|.:.|......|.||||.|||.||
  Fly   278 HADTCDVKDPKSPVRILACRCQHHTCGIQCNECCPGFEQKKWRQNTNARPFNCEPCNCHGHSNEC 342

Mouse   346 TFDRELYRS------TGH---GGHCQRCRDHTTGPHCERCEKNYYR-----WSPKTPCQP----- 391
            .:|.|:.|.      .||   ||.||.|:.:|.|.:|.:|:..|||     |:....|.|     
  Fly   343 KYDEEVNRKGLSLDIHGHYDGGGVCQNCQHNTVGINCNKCKPKYYRPKGKHWNETDVCSPCQCDY 407

Mouse   392 ----------------------------------------------------------------- 391
                                                                             
  Fly   408 FFSTGHCEEETGNCECRAAFQPPSCDSCAYGYYGYPNCRECECNLNGTNGYHCEAESGQQCPCKI 472

Mouse   392 ----------------------CDCHPAGSLS--------------------------------- 401
                                  |:|:..||::                                 
  Fly   473 NFAGAYCKQCAEGYYGFPECKACECNKIGSITNDCNVTTGECKCLTNFGGDNCERCKHGYFNYPT 537

Mouse   402 ---LQCDN-----------SGVCPCKPTVTGWKCDRCLPGFHSLSEGGCRPCACNVAGS------ 446
               ..|||           ||.|.|:....|.:||:|||||::..:  |:||.|:..||      
  Fly   538 CSYCDCDNQGTESEICNKQSGQCICREGFGGPRCDQCLPGFYNYPD--CKPCNCSSTGSSAITCD 600

Mouse   447 ----------------------------------------------------------------- 446
                                                                             
  Fly   601 NTGKCNCLNNFAGKQCTLCTAGYYSYPDCLPCHCDSHGSQGVSCNSDGQCLCQPNFDGRQCDSCK 665

Mouse   447 ----------------------------------------------------------------- 446
                                                                             
  Fly   666 EGFYNFPSCEDCNCDPAGVIDKFAGCGSVPVGELCKCKERVTGRICNECKPLYWNLNISNTEGCE 730

Mouse   447 ------------LGTCDPRSGNCPCKENVEGSLCDRCRPGTFNLQPHNPVGCSSCFC-YGHS--K 496
                        |.||..:||.||||.:.:|..|..||.|||:|...:..||..|.| .|.|  .
  Fly   731 ICDCWTDGTISALDTCTSKSGQCPCKPHTQGRRCQECRDGTFDLDSASLFGCKDCSCDVGGSWQS 795

Mouse   497 VCSPAAGFQE----------------------HHIRSDFRHGA--GGWQIR------------SM 525
            ||...:|..:                      |..:.::..|:  .|.|:|            |.
  Fly   796 VCDKISGQCKCHPRITGLACTQPLTTHFFPTLHQFQYEYEDGSLPSGTQVRYDYDEAAFPGFSSK 860

Mouse   526 G-------------------------------------------VSKRPLQ-------------- 533
            |                                           .|..||:              
  Fly   861 GYVVFNAIQNDVRNEVNVFKSSLYRIVLRYVNPNAENVTATISVTSDNPLEVDQHVKVLLQPTSE 925

Mouse   534 ---------------------------------------------WSQSGLL---------LG-- 542
                                                         :.::|:|         ||  
  Fly   926 PQFVTVAGPLGVKPSAIVLDPGRYVFTTKANKNVMLDYFVLLPAAYYEAGILTRHISNPCELGNM 990

Mouse   543 -----------------------------------------------------LRGGEE-----L 549
                                                                 |.|.:.     :
  Fly   991 ELCRHYKYASVEVFSPAATPFVIGENSKPTNPVETYTDPEHLQIVSHVGDIPVLSGSQNELHYIV 1055

Mouse   550 SAPKK--------FLGDQRL--SYG---------------------------------------- 564
            ..|:.        ::.|:..  ||.                                        
  Fly  1056 DVPRSGRYIFVIDYISDRNFPDSYYINLKLKDNPDSETSVLLYPCLYSTICRTSVNEDGMEKSFY 1120

Mouse   565 ------QPVILTLQVPPGG----------------------SP---------------------- 579
                  ||||::..:..|.                      ||                      
  Fly  1121 INKEDLQPVIISADIEDGSRFPIISVTAIPVDQWSIDYINPSPVCVIHDQQCATPKFRSVPDSKK 1185

Mouse   580 ---------------PP------------------------------------------------ 581
                           ||                                                
  Fly  1186 IEFETDHEDRIATNKPPYASLDERVKLVHLDSQNEATIVIESKVDATKPNLFVILVKYYQPSHPK 1250

Mouse   582 -------------------IQLRLEGAGLALSLRPSSLPSPQ---------DTRQPRRVQLQF-- 616
                               ||.....:|....:||:...|.:         .|.:.:.|.|.:  
  Fly  1251 YQVYYTLTAGKNQYDGKFDIQHCPSSSGCRGVIRPAGEGSFEIDDEFKFTITTDRSQSVWLDYLV 1315

Mouse   617 -----------LLQETSEEAESPLPT-----FHFQRLLSNLTALSIW------------------ 647
                       |::||.::.:..:..     ||.....|:....|::                  
  Fly  1316 VVPLKQYNDDLLVEETFDQTKEFIQNCGHDHFHITHNASDFCKKSVFSLTADYNSGALPCNCDYA 1380

Mouse   648 ---------------------------------------------------TSGQ---------- 651
                                                               |:|:          
  Fly  1381 GSTSFECHPFGGQCQCKPNVIERTCGACRSRYYGFPDCKPCKCPNSAMCEPTTGECMCPPNVIGD 1445

Mouse   652 -----GPGHSG--QVLLCE---------------------------------------------- 663
                 .|...|  ||:.||                                              
  Fly  1446 LCEKCAPNTYGFHQVIGCEECACNPMGIANGNSQCDLFNGTCECRQNIEGRACDVCSNGYFNFPH 1510

Mouse   664 ----------------------------------------------------------------- 663
                                                                             
  Fly  1511 CEQCSCHKPGTELEVCDKIDGACFCKKNVVGRDCDQCVDGTYNLQESNPDGCTTCFCFGKTSRCD 1575

Mouse   664 --------------VQLTS-----------AWP------------------QRE----------- 674
                          |.:|:           .||                  .||           
  Fly  1576 SAYLRVYNVSLLKHVSITTPEFHEESIKFDMWPVPADEILLNETTLKADFTLREVNDERPAYFGV 1640

Mouse   675 ---------------------------------LAP----------------------------- 677
                                             :||                             
  Fly  1641 LDYLLNQNNHISAYGGDLAYTLHFTSGFDGKYIVAPDVILFSEHNALVHTSYEQPSRNEPFTNRV 1705

Mouse   678 -------------PAS--------------------W---------------------------- 681
                         |.|                    |                            
  Fly  1706 NIVESNFQTISGKPVSRADFMMVLRDLKVIFIRANYWEQTLVTHLSDVYLTLADEDADGTGEYQF 1770

Mouse   682 --VETCLCPQGYTGQFCEFCALGYKREIPHGGPYAN-CIPCTCNQHG-TCDPNTGIC-LCGHHTE 741
              ||.|.||.||:|..||.||.||.|:  ..|||.. ||||.||.|. |||..|||| .|.|.||
  Fly  1771 LAVERCSCPPGYSGHSCEDCAPGYYRD--PSGPYGGYCIPCECNGHSETCDCATGICSKCQHGTE 1833

Mouse   742 GPSCERCMPGFYGNAFSGRADDCQPCPCP------GQSACATIPESGDVVCTHCPPGQRGRRCES 800
            |..||||:.|:||||.:|...||..|.||      ..:....|.||||.:...|.||..|.||||
  Fly  1834 GDHCERCVSGYYGNATNGTPGDCMICACPLPFDSNNFATSCEISESGDQIHCECKPGYTGPRCES 1898

Mouse   801 CEDGFFGDPLGLSGAPQPCRRCQCSGNVDLNAVGNCDPHSGHCLRCLYNTTGAHCEHCREGFYGS 865
            |.:||:|:|..:.   |.|:.|:||||::....|:||..:|.|||||.||.||.|..|..||||.
  Fly  1899 CANGFYGEPESIG---QVCKPCECSGNINPEDQGSCDTRTGECLRCLNNTFGAACNLCAPGFYGD 1960

Mouse   866 AVATRPVDKCAPCSCDLRGSVSEKTCNPVTGQCVCLPYVSGRDCSRCSPGFYDLQSGRGCQSCKC 930
            |:..:   .|..|.||..|:   :||:|..|.|.|...|.|..|.||.|..|..:||.||::|.|
  Fly  1961 AIKLK---NCQSCDCDDLGT---QTCDPFVGVCTCHENVIGDRCDRCKPDHYGFESGVGCRACDC 2019

Mouse   931 HPLGSLEN--KCHPKTGQCPCRPGVTGQACDRCQLGFFGFSIKGCRDCRCSPLGAASSQCHENS- 992
               |:..|  :|.|.||.|.|:.||||:.||||.:..:.:...||..|.|:...:....|:.|: 
  Fly  2020 ---GAASNSTQCDPHTGHCACKSGVTGRQCDRCAVDHWKYEKDGCTPCNCNQGYSRGFGCNPNTG 2081

Mouse   993 TCVCRPGFVGYKCDRCQDNFFLADGDTGCQECPTCYALVKEEAAKLKARLMLMEGWLQRSDCGSP 1057
            .|.|.||.:|.:||.|.:.:.|.. |.|||||..|:..:.:...:::                  
  Fly  2082 KCQCLPGVIGDRCDACPNRWVLIK-DEGCQECNNCHHALLDVTDRMR------------------ 2127

Mouse  1058 WGPLDILQGEAPLGDVYQGHHLLQE----TRGTFLQQMVGLEDSVKATWEQLQVLRGHVHCAQAG 1118
                            ||...:|::    |...|..|.:...|.:....|....|........:.
  Fly  2128 ----------------YQIDSVLEDFNSVTLAFFTSQKLNYYDQLADELEPKVKLLDPNSVDLSP 2176

Mouse  1119 AQKTCIQLAELEETLQSSEEEVLRA-ASALSFLASLQKGSSTPTNWSHLASEAQILARSHRDTAT 1182
            ::|.   .:|||...:|..::|.:. |:|...   .::.|:|..|.:....||...|...::...
  Fly  2177 SKKA---NSELESDAKSYAKQVNQTLANAFDI---RERSSTTLGNITVAYDEAVKSADQAKEAIA 2235

Mouse  1183 KIEATSERALLAS----NASYELLKLMEGRVASEA------QQELEDR---YQEVQAAQTALGIA 1234
            .:||.|:....|:    :|:.|..:.:.|::...:      :|.||..   |:||...       
  Fly  2236 SVEALSKNLEAAASTKIDAALEQAQHILGQINGTSIELTPNEQVLEKARKLYEEVNTL------- 2293

Mouse  1235 VAEALP-KAE-KALATVKQVIGDAAPHLGLLVT------PEAMNFQARGLSWKVKAL-------- 1283
               .|| ||: |:|..:|..||:.:.||..|..      .::.:.:.|.:: ..||.        
  Fly  2294 ---VLPIKAQNKSLNALKNDIGEFSDHLEDLFNWSEASQAKSADVERRNVA-NQKAFDNSKFDTV 2354

Mouse  1284 -EQKLEQKE----------------PEVGQSVGALQVEAGRALEKME----------PFMQLRNK 1321
             ||||:.::                .::.|.:..|:    .||.::.          |..:.::|
  Fly  2355 SEQKLQAEKNIKDAGNFLINGDLTLNQINQKLDNLR----DALNELNSFNKNVDEELPVREDQHK 2415

Mouse  1322 TTAAFTRASSAVQAAKVTVIGAETLLADLEGMKLRSPLPKEQAALKKKAGSIRTRLLEDTKRKTK 1386
            ...|.|  ..|.|.|....|.|:.|.|....|...:    |.|.....|.|.....:|..::.::
  Fly  2416 EADALT--DQAEQKAAELAIKAQDLAAQYTDMTASA----EPAIKAATAYSGIVEAVEAAQKLSQ 2474

Mouse  1387 QAERMLGNAASLSSSTKKKSKEAELMSKDNAKLSRALLREGKQGYRHA-SRLASQTQATLRRASR 1450
            .|....|||...:...::::..|:..|.|       ||:..:|..:.. ..|..:..|:..:..:
  Fly  2475 DAISAAGNATDKTDGIEERAHLADTGSTD-------LLQRARQSLQKVQDDLEPRLNASAGKVQK 2532

Mouse  1451 LLLTSEAHKQELEEAKQVTSGL-STVERQI-RESRISLEKDTKVLSELLVKLGSLGVHQAPAQ-- 1511
            :...:.|.:.:|::..::...| :..:|.: :.|..:.....::|..:|..|..:.| |.|.:  
  Fly  2533 ISAVNNATEHQLKDINKLIDQLPAESQRDMWKNSNANASDALEILKNVLEILEPVSV-QTPKELE 2596

Mouse  1512 -------TLNETQRALESLRLQLDSHGALHHKLRQLEEESARQELQI--------QSFEDDLAEI 1561
                   .|:.|.:.:.....|||.......||.:|.|:...|:.::        |..|:..|::
  Fly  2597 KAHGINRDLDLTNKDVSQANKQLDDVEGSVSKLSELAEDIEEQQHRVGSQSRQLGQEIENLKAQV 2661

Mouse  1562 RADKHNLETI 1571
            .|.:....:|
  Fly  2662 EAARQLANSI 2671

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Lamc3NP_035966.2 Laminin_N 53..278 CDD:278484 74/245 (30%)
EGF_Lam 279..326 CDD:238012 23/50 (46%)
Laminin_EGF 336..392 CDD:278482 28/161 (17%)
EGF_Lam 391..437 CDD:238012 20/184 (11%)
Laminin_EGF 439..486 CDD:278482 21/194 (11%)
Laminin_B 550..669 CDD:278481 39/549 (7%)
EGF_Lam 718..765 CDD:238012 28/48 (58%)
EGF_Lam 766..814 CDD:238012 21/53 (40%)
Laminin_EGF 822..>864 CDD:278482 22/41 (54%)
Laminin_EGF 878..925 CDD:278482 19/46 (41%)
Laminin_EGF 928..976 CDD:278482 20/49 (41%)
EGF_Lam 976..1022 CDD:238012 15/46 (33%)
Domain II and I 1025..1581 115/628 (18%)
Laminin_I 1225..1470 CDD:283627 54/288 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1382..1413 5/30 (17%)
GluZincin 1433..>1506 CDD:301352 10/75 (13%)
LanANP_476617.1 LamNT 18..271 CDD:214532 77/252 (31%)
EGF_Lam 272..>314 CDD:238012 21/41 (51%)
EGF_Lam 332..389 CDD:238012 25/56 (45%)
EGF_Lam 402..443 CDD:238012 1/40 (3%)
EGF_Lam 448..491 CDD:238012 0/42 (0%)
Laminin_EGF 495..543 CDD:278482 4/47 (9%)
Laminin_EGF 541..589 CDD:278482 18/49 (37%)
Laminin_EGF 587..634 CDD:278482 4/46 (9%)
EGF_Lam 631..673 CDD:238012 0/41 (0%)
Laminin_EGF 677..729 CDD:278482 0/51 (0%)
Laminin_EGF 732..782 CDD:278482 17/49 (35%)
EGF_Lam 785..828 CDD:238012 7/42 (17%)
CBM6-CBM35-CBM36_like 831..966 CDD:271143 9/134 (7%)
Laminin_EGF 1375..1423 CDD:278482 0/47 (0%)
EGF_Lam 1420..1457 CDD:238012 3/36 (8%)
Laminin_EGF 1466..1516 CDD:278482 0/49 (0%)
Laminin_EGF 1514..1562 CDD:278482 0/47 (0%)
LamB 1632..1760 CDD:214597 5/127 (4%)
Laminin_EGF <1775..1801 CDD:278482 13/27 (48%)
EGF_Lam 1808..1851 CDD:238012 26/42 (62%)
EGF_Lam 1859..1907 CDD:214543 20/47 (43%)
EGF_Lam 1916..1968 CDD:238012 25/54 (46%)
EGF_Lam 1969..2015 CDD:238012 20/48 (42%)
EGF_Lam 2016..>2054 CDD:238012 18/40 (45%)
EGF_Lam 2063..>2097 CDD:238012 11/33 (33%)
Laminin_I 2129..2385 CDD:283627 54/272 (20%)
Tar 2278..2662 CDD:223910 82/412 (20%)
Laminin_II 2566..2700 CDD:283628 22/107 (21%)
LamG 2674..2843 CDD:238058
LamG 2878..3029 CDD:238058
LamG 3078..3205 CDD:214598
LamG 3349..3512 CDD:238058
LamG 3535..3689 CDD:238058
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1836
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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