DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Insrr and Eph

DIOPT Version :9

Sequence 1:XP_006501514.1 Gene:Insrr / 23920 MGIID:1346037 Length:1313 Species:Mus musculus
Sequence 2:NP_524625.3 Gene:Eph / 43803 FlyBaseID:FBgn0025936 Length:1096 Species:Drosophila melanogaster


Alignment Length:716 Identity:189/716 - (26%)
Similarity:292/716 - (40%) Gaps:175/716 - (24%)


- Green bases have known domain annotations that are detailed below.


Mouse   689 PCQHSPPGQALP-----------------ALEAQEVTFQKKFENFLHHAITIPKAPWKVTSIN-- 734
            || :|||  |.|                 :..|:..:|..:..:.::|:..:.|....:.|.|  
  Fly   382 PC-YSPP--AAPTNLTLLFVDQTSAIISWSAPAKNESFSSETNSKIYHSDIVYKIKCNICSPNVV 443

Mouse   735 KNPQRDSERHRREAGLLRLGKNNSDFEIQEDKVPRERAILSGLRHFTEYRIDIHACNHAAH---- 795
            .||..|:                    ..|.|:     .|:.|...|.|.:.|||.|..:|    
  Fly   444 YNPSTDT--------------------FNETKI-----TLTNLEPVTTYTVQIHAINSVSHINEF 483

Mouse   796 ------TVGCSAATFVFARTMPHREADGIPGKVAWKAAGKSSVT--------------------- 833
                  :...:.:..||:.|    ....||..:.....|::.:.                     
  Fly   484 KRHSNESSLVAVSDIVFSNT----SLLNIPLDLNEVKTGQAEIVFTTESVLLSTVFNLRILAITN 544

Mouse   834 ----LHWLEPPDPNGLILKYEIK-YRRLGEEATVLCVSRLRYAKVGGVHLALLPPGNYSAKVRAT 893
                |.|.:|...:..:..||:: :.::  |...:..|.|...:.....:.||....|..:||..
  Fly   545 KDADLEWDKPVQSDFPLEFYEVRWFPKV--ELDAINKSALNTKETKAHIVGLLENTEYGFQVRCK 607

Mouse   894 SLAGNGSWTDGVTFYITDLEE-----EDTGGMRIF--LTVTPVGFMLLVTLAALGFFYSR----- 946
            :..|.||:::.:  |...|:.     :|:..:|..  ..||.|.|:::..:|.:.|..|:     
  Fly   608 TNNGFGSYSNMI--YAQTLQSVGSVYDDSVQIRFIAGAIVTGVLFLVIFIIATVYFMRSKHQDDL 670

Mouse   947 KRNST-------------------------LYTSVNPEYFSASHMYV-PDEWEVPREQI-AIIRE 984
            .:.||                         |:.:|....|..|..|| |..:|.|.:.| ...||
  Fly   671 DKKSTNHLPLPLDYASNEVNSMDTTPIVKKLHLNVTTPLFGNSRSYVDPHTYEDPNQAIREFARE 735

Mouse   985 -----------LGQGSFGMVYEGLARGLEAGEESTPVALKTVNELASARERVEFLKEASVMKAFK 1038
                       :|.|.||.|..|..:......:...||:||:...:|.:.|.:||.|||:|..|.
  Fly   736 IDANYITIEAIIGGGEFGDVCRGRLKIPPNFVQDIDVAIKTLKPGSSEKARCDFLTEASIMGQFD 800

Mouse  1039 CHHVRQEGLPQRSLSSQVRLLGVVSQGQPTLVIMELMTRGDLKSHLRSLRPEAENNPGLPQPALS 1103
            ..:|             :.|.|||::..|.::|.|.|..|.|.:.||.       |.|..|..  
  Fly   801 HPNV-------------IYLQGVVTRSNPVMIITEYMENGSLDTFLRV-------NDGKFQTL-- 843

Mouse  1104 DMIQMAGEIADGMAYLAAKKFVHRDLAARNCMVSQDFTVKIGDFGMTRDVYETD--YYRKGGKGL 1166
            .:|.|...||.||:||:...:|||||||||.:|:.....||.|||::|::....  |..:|||  
  Fly   844 QLIVMLRGIASGMSYLSDMNYVHRDLAARNVLVNAQLICKIADFGLSREIENASDAYTTRGGK-- 906

Mouse  1167 LPVRWMAPESLKDGIFTTHSDVWSFGVVLWEIVTLAEQPYQGLSNEQVLKFVMDGGVLEELENCP 1231
            :||||.|||::....||:.|||||:||||||:::..|:||...||:.|:|.:..|..|....:||
  Fly   907 IPVRWTAPEAIAFRKFTSASDVWSYGVVLWEVMSYGERPYWNWSNQDVIKSIEKGYRLPAPMDCP 971

Mouse  1232 IQLQELMRLCWQHSPRLRPTFVHILDRIQDELRPSFRLCSFYYSPEC--------QRGQASLLPT 1288
            ..|.:||..|||.....||||..|:..:.:..|....|.:...|||.        ||||...:.|
  Fly   972 EALYQLMLDCWQKQRTHRPTFASIVSTLDNLARQPQSLLTTRPSPESDGNHILDGQRGQNIFIST 1036

Mouse  1289 E 1289
            :
  Fly  1037 D 1037

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
InsrrXP_006501514.1 Recep_L_domain 47..157 CDD:366426
Furin-like 173..329 CDD:366287
Recep_L_domain 346..459 CDD:366426
FN3 494..600 CDD:238020
FN3 605..>649 CDD:238020
FN3 819..908 CDD:238020 18/114 (16%)
PTKc_InsR_like 972..1261 CDD:173625 110/302 (36%)
EphNP_524625.3 EphR_LBD 85..260 CDD:198439
FN3 387..476 CDD:238020 21/115 (18%)
FN3 536..623 CDD:238020 17/90 (19%)
EphA2_TM 644..736 CDD:291255 20/91 (22%)
PTKc_EphR 736..1002 CDD:270629 105/289 (36%)
Pkinase_Tyr 741..999 CDD:285015 105/281 (37%)
SAM_1 1033..1092 CDD:278937 1/5 (20%)
SAM 1039..1092 CDD:197735
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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