DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lrit1 and DIP-delta

DIOPT Version :9

Sequence 1:	NP_666357.2	Gene:	Lrit1 / 239037	MGIID:	2385320	Length:	624	Species:	Mus musculus
Sequence 2:	NP_001097508.2	Gene:	DIP-delta / 5740816	FlyBaseID:	FBgn0085420	Length:	469	Species:	Drosophila melanogaster

Alignment Length:	366	Identity:	74/366 - (20%)
Similarity:	126/366 - (34%)	Gaps:	114/366 - (31%)

- Green bases have known domain annotations that are detailed below.

Mouse   178 WAHLKTGPFLSGHH------ARLILGLQDNPWVC-------DCRLYDL-----------VHLLDG 218
            |.|:.....|:.|.      .|..:...||.|:.       |.|.|.:           |..|..
  Fly    77 WIHIDRQMILTIHRHVISRIPRYSITYTDNTWLLHVNQAHQDDRGYYMCQVNTNPMISQVGYLQV 141

Mouse   219 WVSSNLIFIEARLRCASPRSLAGVAFSQLELRKCQSPELRPGVTSIISPLGSTVLLRCGATGIPG 283
            .|..|::.||     ::|.|:|        :|:.|:                 :.:.|.|.|.|.
  Fly   142 VVPPNILDIE-----STPSSVA--------VRENQN-----------------INMTCRADGFPA 176

Mouse   284 PEMSWRRANGRPLNGTVHQEVSSDGSSWTL------LDLPVVSLFDSGDYICQAKNFL--GASET 340
            |::.|||.:|        :|::.:.....|      |.|..||..:.|.|:|.|.|.:  ..|:.
  Fly   177 PKIIWRREDG--------EEIAVEKKKKVLVYDADVLPLTKVSRNEMGAYLCIATNGVPPSVSKR 233

Mouse   341 LI-----SLIVTEPQTSTGY-SGIPGVLWARTGEGAEAA---AYNNKLVARHVPHMPEHVALATK 396
            :|     |.::..|....|. ||....:...|....:|.   .||:.:|.....:..::...:.:
  Fly   234 IILDVEFSPMIWVPNQLVGAPSGTDVTIDCHTEAHPKAIIYWVYNSVMVLPSKKYKTDYTENSYR 298

Mouse   397 PSMPSIKEELALQNFQMDVPGEFSREPSEHQEAQMVRSLKVVGDTYHSVSLVWKAP-------QA 454
            ..|     :|.::|.|.   |:|..        ....|...:|:|..|:. |::.|       |.
  Fly   299 AHM-----KLTIRNLQY---GDFGN--------YRCISKNSLGETEGSIR-VYEIPLPSTPSKQV 346

Mouse   455 GNTTAFSVLYAVFGHRDMRRMTVEPGKTSVTIEGLAPKTKY 495
            .:||.           :.|...:.|...:.|.:.|.....|
  Fly   347 THTTV-----------ESRENNIIPSSRNDTTKSLQTDVGY 376

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lrit1	NP_666357.2	LRRNT	23..61	CDD:214470
		LRR 1	60..81
		LRR_8	63..143	CDD:290566
		leucine-rich repeat	64..84	CDD:275378
		LRR 2	84..105
		leucine-rich repeat	85..132	CDD:275378
		LRR 3	108..129
		LRR_8	131..>176	CDD:290566
		LRR_4	131..172	CDD:289563
		LRR 4	132..153
		leucine-rich repeat	133..156	CDD:275378
		LRR 5	156..177
		leucine-rich repeat	157..180	CDD:275378	1/1 (100%)
		leucine-rich repeat	181..205	CDD:275378	6/29 (21%)
		TPKR_C2	201..>241	CDD:301599	13/57 (23%)
		Ig	258..346	CDD:299845	23/100 (23%)
		IG_like	268..346	CDD:214653	23/90 (26%)
		FN3	432..502	CDD:214495	14/71 (20%)
		LRR 6	526..549
DIP-delta	NP_001097508.2	IG	51..143	CDD:214652	13/65 (20%)
		Ig	145..238	CDD:416386	30/130 (23%)
		Ig strand A	145..149	CDD:409353	1/3 (33%)
		Ig strand A'	154..159	CDD:409353	3/12 (25%)
		Ig strand B	165..172	CDD:409353	1/6 (17%)
		Ig strand C	178..183	CDD:409353	1/4 (25%)
		Ig strand C'	185..187	CDD:409353	1/9 (11%)
		Ig strand D	195..199	CDD:409353	0/3 (0%)
		Ig strand E	203..209	CDD:409353	2/5 (40%)
		Ig strand F	216..223	CDD:409353	3/6 (50%)
		Ig strand G	230..238	CDD:409353	2/7 (29%)
		Ig	242..333	CDD:416386	19/107 (18%)
		Ig strand A'	250..253	CDD:409353	0/2 (0%)
		Ig strand B	259..266	CDD:409353	0/6 (0%)
		Ig strand C	272..277	CDD:409353	0/4 (0%)
		Ig strand C'	281..283	CDD:409353	0/1 (0%)
		Ig strand D	289..293	CDD:409353	0/3 (0%)
		Ig strand E	295..305	CDD:409353	2/14 (14%)
		Ig strand F	314..322	CDD:409353	1/15 (7%)
		Ig strand G	325..334	CDD:409353	3/9 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900