DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gpr34 and AstC-R1

DIOPT Version :9

Sequence 1:	NP_035953.3	Gene:	Gpr34 / 23890	MGIID:	1346334	Length:	375	Species:	Mus musculus
Sequence 2:	NP_649040.2	Gene:	AstC-R1 / 40020	FlyBaseID:	FBgn0036790	Length:	483	Species:	Drosophila melanogaster

Alignment Length:	402	Identity:	97/402 - (24%)
Similarity:	161/402 - (40%)	Gaps:	64/402 - (15%)

- Green bases have known domain annotations that are detailed below.

Mouse     2 TTTSVDSWLCSSHGMHFITNYSDQASQNFSG--VPNVTSCPMDEKLLSTVLT-TFYSVIFLVGLV 63
            ||.....|:..|..:        |..::..|  :|....|.......:.:.| ..|..:.::||.
  Fly    37 TTELNHRWISGSSTI--------QPEESLYGTDLPTYQHCIATRNSFADLFTVVLYGFVCIIGLF 93

Mouse    64 GNIIALYVFLGIHRKRNSIQIYLLNVAVADLLLIFCLPFRIMYHINQNKWTLGVILCKVVGTLFY 128
            ||.:.:||.|...:.:....||:||:||||...:..:|| ::|.:....|..|..:||.......
  Fly    94 GNTLVIYVVLRFSKMQTVTNIYILNLAVADECFLIGIPF-LLYTMRICSWRFGEFMCKAYMVSTS 157

Mouse   129 MNMYISIILLGFISLDRYIKINRSIQQRRAITTKQSIYVCCIVWTVALAGFLTMIILTL---KKG 190
            :..:.|.|.|..:|.||||.:...|...|..|...:..|..|.|:.:....|.:|:...   ::.
  Fly   158 ITSFTSSIFLLIMSADRYIAVCHPISSPRYRTLHIAKVVSAIAWSTSAVLMLPVILYASTVEQED 222

Mouse   191 GHNSTMCFHYRDRHNAKGEAIFNFVLVVMFWLIF---LLIILSYIKIGKNLLRISKRRSKFPNSG 252
            |.|.:....:.|.:.......|   ::..|:|.|   |..|||:.     .|.|.|.||..|..|
  Fly   223 GINYSCNIMWPDAYKKHSGTTF---ILYTFFLGFATPLCFILSFY-----YLVIRKLRSVGPKPG 279

Mouse   253 KYATTARNS--------FIVLIIFTICFVPYHAFRFIYISS---QLNVSSCYWKEIIHKTNEIM- 305
            ..:...|.:        ..|:.::.:|::|:...:...|.|   |.::|..          ||:
  Fly   280 TKSKEKRRAHRKVTRLVLTVISVYILCWLPHWISQVALIHSNPAQRDLSRL----------EILI 334

Mouse   306 ------LVFSSFNSCLDPVMYFLMSSNIRK-----IMC---QLLFRRFQSEASRSESTSEFKPGH 356
                  ||:|  ||.::|::|..:|.|.||     ..|   |.:..:.|.|.|........|.|.
  Fly   335 FLLLGALVYS--NSAVNPILYAFLSENFRKSFFKAFTCMNKQDINAQLQLEPSVFTKQGSKKRGG 397

Mouse   357 SLHDLSVTVKMP 368
            |...|:...::|
  Fly   398 SKRLLTSNPQIP 409

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gpr34	NP_035953.3	7tmA_GPR34-like	48..331	CDD:320276	79/312 (25%)
		TM helix 1	50..74	CDD:320276	8/24 (33%)
		TM helix 2	83..104	CDD:320276	10/20 (50%)
		TM helix 3	121..143	CDD:320276	4/21 (19%)
		TM helix 4	166..182	CDD:320276	4/15 (27%)
		TM helix 5	209..232	CDD:320276	8/25 (32%)
		TM helix 6	258..280	CDD:320276	4/29 (14%)
		TM helix 7	299..324	CDD:320276	9/31 (29%)
AstC-R1	NP_649040.2	7tm_4	88..368	CDD:304433	77/300 (26%)
AstC-R1	NP_649040.2	7tm_1	94..353	CDD:278431	70/279 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000