DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fbln5 and frac

DIOPT Version :9

Sequence 1:	NP_001348916.1	Gene:	Fbln5 / 23876	MGIID:	1346091	Length:	461	Species:	Mus musculus
Sequence 2:	NP_001137905.1	Gene:	frac / 38850	FlyBaseID:	FBgn0035798	Length:	1618	Species:	Drosophila melanogaster

Alignment Length:	385	Identity:	127/385 - (32%)
Similarity:	169/385 - (43%)	Gaps:	88/385 - (22%)

- Green bases have known domain annotations that are detailed below.

Mouse    30 LPHPGNAQQQCTN-----------GFD---LDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYL 80
            |.:.|..||.|.|           |::   ||...|.|.|||||......|...|:|.|.||.|.
  Fly   637 LVNNGGCQQVCRNLPGSYGCICAAGYELLKLDGIRGYCFDIDECSQRTHGCSDQMLCENLNGSYT 701

Mouse    81 CIPRTNPVYRGPYSNPYSTSYSGPYPAAAPPVPASNYPTISRPLVCRFGYQMDEGNQCVDVDECA 145
            |:  ..|.|.....|...||.:            |::.|.|.      ..:....:.|:|:|||:
  Fly   702 CL--CPPGYALGLDNHIVTSLN------------SSFITDST------SSETPSAHTCLDIDECS 746

Mouse   146 TDSHQCNPTQICINTEGGYTCSCTDGYWLLEGQ--CLDIDEC--RYGYCQQLCANVPGSYSCTCN 206
            ..:..|  :..|.|..||:.|:|..||.|.|..  |.|||||  ..|.|.|||.|.||.::|.|.
  Fly   747 LANGNC--SHFCQNEPGGFQCACPLGYALSEDMRTCQDIDECLDSNGQCSQLCLNQPGGFACACE 809

Mouse   207 PGFTLNDDGRSCQDVNECETE-NPCVQTCVNTYGSFICRCDPGYELEEDGIHCSDMDECS-FSEF 269
            .||.|..||..|.|::||..: ..|...|:|..|:..|.|:.||||.:|.:.|.|:|||: ....
  Fly   810 TGFELTPDGFGCADIDECSQDYGNCSDICINLLGTHACACERGYELAKDKLSCLDVDECAGLLSG 874

Mouse   270 LCQHECVNQPGSYFCSCPPGYVLLDDNRSCQ---------------------------------- 300
            .|.|||:|:.|::.|.||.||:|.||.|||.
  Fly   875 GCSHECINKAGTFECGCPLGYILNDDGRSCSPALVGCPPGTQRSADGCAPIECNPGYTLGSDDKC 939

Mouse   301 -DINECEHRNHTCTSLQTCYNLQGGFKCIDPISCEEPYLLIGENR-CM----CPAEHTSC 354
             ||:||:.:|..|:  ..|.|.:|.|||    ||...|.|..:.: |.    |..:.|||
  Fly   940 VDIDECQKQNGGCS--HRCSNTEGSFKC----SCPPGYELDSDQKTCQDIDECDQDKTSC 993

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fbln5	NP_001348916.1	vWFA	<134..178	CDD:320736	16/43 (37%)
		cEGF	200..223	CDD:315355	9/22 (41%)
		EGF_CA	220..258	CDD:214542	14/38 (37%)
		FXa_inhibition	271..299	CDD:317114	15/27 (56%)
frac	NP_001137905.1	FXa_inhibition	296..331	CDD:291342
		cEGF	396..415	CDD:289433
		FXa_inhibition	425..458	CDD:291342
		FXa_inhibition	476..505	CDD:291342
		vWFA	<550..586	CDD:294047
		FXa_inhibition	596..630	CDD:291342
		FXa_inhibition	636..>664	CDD:291342	7/26 (27%)
		EGF_CA	676..715	CDD:284955	15/40 (38%)
		FXa_inhibition	745..780	CDD:291342	12/36 (33%)
		FXa_inhibition	786..821	CDD:291342	16/34 (47%)
		FXa_inhibition	827..862	CDD:291342	12/34 (35%)
		FXa_inhibition	874..904	CDD:291342	15/29 (52%)
		FXa_inhibition	945..980	CDD:291342	13/40 (33%)
		CCP	1110..1170	CDD:153056
		CCP	1183..1235	CDD:153056
		DUF5011	1468..1536	CDD:295940
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24034
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	3	2.970