DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Dido1 and upSET

DIOPT Version :9

Sequence 1:NP_780760.2 Gene:Dido1 / 23856 MGIID:1344352 Length:2256 Species:Mus musculus
Sequence 2:NP_001261819.1 Gene:upSET / 39551 FlyBaseID:FBgn0036398 Length:3146 Species:Drosophila melanogaster


Alignment Length:2498 Identity:449/2498 - (17%)
Similarity:780/2498 - (31%) Gaps:824/2498 - (32%)


- Green bases have known domain annotations that are detailed below.


Mouse    86 NVPVSLEDSSEPTSSTVTDVETASEGSVESSSEIRSGPVSDSLGKEHPASSEKAKGGEEEEDTSD 150
            ||||.:| ::.|:|..:          |:.||:..:.| .....:.||....:....:||     
  Fly   671 NVPVHVE-AAPPSSPAL----------VKGSSQPPAQP-QQQQQQAHPLGPNQLNANDEE----- 718

Mouse   151 SDSDGLTLKE------LQNRLRRKREQEPVERSLRGSQNRLRKKRREEDSAETGSVQIGSAEQDR 209
                 |.::|      |...||.::....::.....||    :::::...|...:...|:|:|  
  Fly   719 -----LYIEEVRPVPVLTQDLRLQQLHAIMQDHTYASQ----QQQQQPQQAAGDTTNPGAAQQ-- 772

Mouse   210 PLCKQEPE------------ASQG--------------PVSQSET-DDIENQLEGKATQG--NTE 245
               .|:|:            .|||              .:::|:. ||..:.:...:..|  :|:
  Fly   773 ---VQQPQQWSLGGIGVTVSGSQGTPTAVGGYCSYFGQQIARSQADDDAHSAISSSSRMGLASTD 834

Mouse   246 ENPREAGKPKPECEVYDPNALYCICRQPHNNRFMICCDRCEEWFHGDCVGISEARGRLLERNGED 310
            .:|.|..:..||.|..|.:...|||...|::.:|||||:|..|.|.||:||..      :...|:
  Fly   835 IDPGEETETAPEAEAEDDSVTRCICELTHDDGYMICCDKCSAWQHVDCMGIDR------QNIPEE 893

Mouse   311 YICPNCTILQVQDETNGSATDEQD-------------SGCRSVGADGTDCTSIGTVEQKSGEDQ- 361
            |:|..|....| |:....|...|.             :|..:|.|..|....:|:....|.|.| 
  Fly   894 YMCELCQPRAV-DKARARALQRQKRKEHMLLVATQAANGAAAVAAGTTLSGGLGSGLPMSEELQH 957

Mouse   362 ----GIKGRI--------------EKAANPSGKKKLKIFQPVVEAPGAPKCIGPGCSSVAQPDSV 408
                |:.|..              |.:.:.|..||.|  :..|...|.....|.|..:.      
  Fly   958 RLASGLNGGFATGTGMSKKSKKTKENSGSTSTLKKTK--KSAVGMGGEKNASGSGTPTG------ 1014

Mouse   409 YCSNDCILKHAAATMRFLSSGKEQKTKPKEKVKTKPEKFSLPKCSVQVGIKISSVHKRLASEKRE 473
                              ||||..|...|.|.|:..:..|....|..:          .|:||..
  Fly  1015 ------------------SSGKTSKKSSKRKSKSGGDGSSGGGSSPAL----------TAAEKHA 1051

Mouse   474 NPVKKVMLASRSETSGKEAACESSTPSWASDHNYNAVKPEKPEKPTAL-----SPTLLSKSMKDD 533
            ..:::                      |..::.|.......||....|     .|:||    :..
  Fly  1052 ANLRQ----------------------WIENYEYAVTNHYSPELRARLHAIQKQPSLL----QSI 1090

Mouse   534 RRVEDRTMAAVTIPKKALPSASLVGRQTSPRNLVPKKLPPYSNMAGAKPAIKK------------ 586
            :..|::.:..:   ::.|.:|....:......|:|        .||||..|..            
  Fly  1091 QNTENKALRQI---QQQLSTAGSAEQLEQRAQLIP--------YAGAKVLISSVDLSPHAPIHEL 1144

Mouse   587 -----LPSGFKGTIP----KRPWPSATLSGTSARQAGPTP-MTAASKKLPGSAAVVGVTRKPMSA 641
                 |.:.|:...|    ..|.||..|:...|.:   || ......:|||..|.:...|...|.
  Fly  1145 RGKYMLTTQFRTQNPTVNMNTPPPSNYLNSFKAHK---TPGQFVFFYQLPGVEAPMQTLRPDGSV 1206

Mouse   642 NVPAASPAPGRLGPVSPAPSQPNSQIRQNIRRSLKEILWKRVNDSDDLIMTENEVGKIALHIEKE 706
            ...|..|.....||.....::......:.:|||.      |.|            .::..:.||.
  Fly  1207 PQVAQQPPSYLKGPEVCVDTRTYGNDARFVRRSC------RPN------------AELQHYFEKG 1253

Mouse   707 MFNLFQVTDNRYKSKYRSIMFNLKDPKNQGLFHRVLREEISLAKLVRMKPEELVSKELSMWTEKP 771
            ..:|:.|                      .|.|...:.||:    :|.:|.:|.:.|    .:|.
  Fly  1254 TLHLYIV----------------------ALTHIRAQTEIT----IRHEPHDLTAVE----QKKS 1288

Mouse   772 TKSVIE-SRTKLLNESKKNT--TKPETIPDMEDSPPVSDSEEQQESVRAAPEKSAAPLLDVFSSM 833
            ..:||: :.|:...:...:.  ..|..:.....:||.......:....||...:||         
  Fly  1289 HAAVIQPTSTRCACDMGSDCLFALPLAVQQQLQAPPTQPRSSHRNKAAAAAAAAAA--------- 1344

Mouse   834 LKDTTSQHRAHLFDLNCKICTGQVPSSEDEPAPKKQKLSASSKKEDFKPRHDSSPPNAVPNTADE 898
                                                                ::...|:..|...
  Fly  1345 ----------------------------------------------------ANSAAAIQLTMGL 1357

Mouse   899 GIADTLPENASE-PDPESTSSLNQERKCFPESPGDSHPEPSSLGGLSPSSASGGSGVVTTVTMSG 962
            |:..|:...||. |:..:.|:         .|.|:|    |.:|..||.......|..|:||   
  Fly  1358 GVGATVAAGASVLPNSRNRST---------SSSGES----SQMGLNSPQLGQLNLGFKTSVT--- 1406

Mouse   963 RDPRTALSGSCTVTASM-AAHLDNSQASETKLDMIKPALTSAVVPKSILAKPSSSPDPRYLSVPP 1026
                     :.::||.: ..|.:||..|.:..:.......|:|:..|.:...||||.   :|: |
  Fly  1407 ---------ATSLTAPVPGVHCNNSGGSSSSSNNSCSVSMSSVLHDSGICTSSSSPS---VSI-P 1458

Mouse  1027 SPSISESRSP---------PEGDTTLFLSRLNTIWKGFINMQSVAKFVTKAYPVSGCLDYLSEDL 1082
            ||:.::.:||         |:...:| |.|..|        |...:.:..|.|.......||..|
  Fly  1459 SPTPTQMQSPTLQQHPQQIPQQQLSL-LQRSPT--------QQHQQQILAALPTPMLTPMLSPQL 1514

Mouse  1083 P----DTIHIGGRIAPKTVWDYVGKLKSSVSKELCLIRFHPATEEEE-VAYIS--------LYSY 1134
            |    ...|:   :.|:             |::..|::...:.:.:| :|.|:        :.:|
  Fly  1515 PKPAQQQAHV---VLPQ-------------SQQTSLLQQQQSQQSQEPLAVIAAAAAAQQPMATY 1563

Mouse  1135 F------------------SSRGRFGVVANNNRH------------VKDLYLIPLSAKDPVPSKL 1169
            |                  .::.:..|.|...:|            :.|...:.:||...:.:  
  Fly  1564 FVRQPQQQQQQQSPKPQALVAQQQHVVGAQQQQHFLQQQQKQQQQQMADEARMAVSALQTLHA-- 1626

Mouse  1170 LPFEGPGLESPRPNII--LGLVICQKVKRPSSAGE--------LDKTDEKRTRLQQEELETSVYP 1224
                     :|..:|:  :.:...|:..:|....:        .....::..:|||::.:...||
  Fly  1627 ---------APTSHIVSPIKVAAVQQQSQPQQQQQNTHQQPHNQQAVQQQSNQLQQQQSQQPNYP 1682

Mouse  1225 K-------------------------VTAALPSEKKPPKYSV------HSIDTAATST------T 1252
            :                         :.|.:|::...|..|.      ::|..:|.|:      |
  Fly  1683 QSPQRQQKPQPVQHQPQIVISTGAQAIPATMPTKLSSPTKSAAPVISNNNITVSAQSSVVGGKKT 1747

Mouse  1253 PPGSPPPPPPLPEPPVLKILSSLKPGSTSTVTA----PTTAAITTTASPVTAATSKTAS-----P 1308
            |...|.......:.||..:.::..|.:|.:.:.    ..:|:.|||.:..|.|..|...     .
  Fly  1748 PAKHPQQQQQQQQQPVTPVSAATAPAATPSSSESKEDDVSASSTTTPTTRTPAKDKPKQSREDRK 1812

Mouse  1309 LEHIL--------QTLFGKKKSFEPSG--KESVGSTLSPHQ--DSKAKGED------TMSAAPLL 1355
            ||.||        |...|||.:.:.||  :::..|..||::  .|.:..||      |.|||...
  Fly  1813 LEAILRAIEKMEKQEARGKKDTRQSSGGKRQASNSPASPNKRNSSNSISEDVETPTSTNSAAAAA 1877

Mouse  1356 DP---------------------------------IVQQFGQFSKDKALEEEEEDDRPYDPEEEY 1387
            ..                                 :|:..|:   ..||...|.:|:...|:..:
  Fly  1878 QRRNKKKRKVSRSLNNNTNGLGSGGGSNNKRRKSIVVESDGE---SHALTNSESEDQGQHPQSHH 1939

Mouse  1388 --NPDRAFHTLLA------EPGRPHDVQSVSETAEREEVAYDPEDET----ILEEAKVTIDDLPN 1440
              :.|:|...|||      .|..|..    |..::...:...|...:    ::|.|...:...| 
  Fly  1940 SGSEDQAAGLLLALAHNNSSPNEPFK----SPLSQSHSLPATPASVSSACLLIEAAMGPLQQQP- 1999

Mouse  1441 RMCMKVSATERPADFTTDASSA----SLVE------QQKMLEELNKQIEEQKRQLEEQEEALRQQ 1495
               ...||:...|:|......|    ||:.      :|:....|:..::....::..:.|.|  |
  Fly  2000 ---APASASPSLAEFKYPPGGAKTKKSLMSSWFQQAEQQHASGLDSLVQAAMSEINGEREQL--Q 2059

Mouse  1496 RAAVGVSMAHFSVSDALMSPPPKSSLGKTELFSQEQQAPDPSQGAPNTNHNLDSRQSRDPRQARR 1560
            |...|.|:             |..:|.|.|.|..:.::..........:..|.:..|...|..|:
  Fly  2060 RQPQGESL-------------PAPALLKVEQFIHQAESTTAVPAREQLHLPLQNNSSVKKRWLRQ 2111

Mouse  1561 LAAENT---------ENESLPRAPTGSTPGPQGTLPARETPAGTAVVQGPGLAAEAKESMAVPWA 1616
            ..:|.|         :|:|:.     :||.||        |..|......|.:...|:...|..:
  Fly  2112 AISEETTPVDELQQSQNQSVT-----ATPSPQ--------PVPTVSPLANGFSTPLKKRRLVVVS 2163

Mouse  1617 PGENAVLRPEHDIQKCEHPGNP------------VSLPLDTSHLPTAGDG--AARPAPPRRV--- 1664
            .|.|.    |.|....:..|.|            :.:.::..|.....|.  ...|:|....   
  Fly  2164 NGTNV----ESDETHIDVIGEPKDEAEENVAMTELKVEIENHHQEQDDDVDILRSPSPGTHQIVA 2224

Mouse  1665 ---LLPTPPSTTFPPSFPLQPKAQNFSSGSREPFSGPTFMSQETS----------LGSSQYEDPR 1716
               |:...|..|...:..::...:...|.:.:.|.....:.:|..          ....::|.|:
  Fly  2225 EDNLVKIEPEDTSAAADDVKIDVEREESQACDKFEEMVKVKREEEEQREKEIKQLQERQEHEQPK 2289

Mouse  1717 --GAQSAGKNDSPVADMEDSREP-------------QPRPGES------------------TTSF 1748
              .|....|.::.||..|...||             :|:||||                  .|:.
  Fly  2290 VEPAPVEPKLENTVAKAEPKVEPSQEIVSKKEPTKVEPKPGESLLRSTATVTATPTAATIAATTL 2354

Mouse  1749 PQPGQRGGGPQPQFPGQREPAPRTFGMSGHHGPSFPGPRGPVPPYSEENLVPNSDGPRGPPPARF 1813
            ....:.....:|....:.||..:...:..    ..|.|...|||.|    ||       |.||..
  Fly  2355 LDVSKVAFKTRPPLKLEDEPQKKKPKLES----ILPAPVATVPPVS----VP-------PIPAAS 2404

Mouse  1814 GAQKPPI-------------PS-------------LFSGQHGPPPYGDNR---------GLSPSY 1843
            .|....:             ||             |.|.......|..:|         ..|||.
  Fly  2405 NATTSAVTNTAAASLTTTTAPSSTKNLTEHDIQERLLSFHAANISYLQSRNKKATAALTSASPSQ 2469

Mouse  1844 LGGPRGGAPAQFEDRKDPHGEKREFQDTPYNEMTGAPAQCEGPDQAQFMGNRAPFQFGGQRRPLL 1908
            ......|...  .:.|....:|.|.:|...........:.:..|:.:   .:|........:.:.
  Fly  2470 KSNSSSGGSG--TESKKSSKDKDEKRDKEKQLKKSKKEKKKSKDKEK---QKAAVNVNSTSQIVD 2529

Mouse  1909 TQMKGPRGGPPPSQFGAQRGP---PPGHFVGPRGPHPSQFENSRGTHPGQFEGARGQAPGFMPGP 1970
            |:.|..:...|.|:  :...|   ||.        .|....|.:..|...               
  Fly  2530 TKKKTTQPSKPDSK--SSIAPVLVPPS--------LPVATANGKTKHTAY--------------- 2569

Mouse  1971 RGIQPQQFEEQRVNSPPRFAGQRASAPLPYGGPRGPAPFPEKNEQPPSRFHFQGPSSQ------- 2028
            ..:..||.::.|..:...........|:....|....|...|..|.........|:||       
  Fly  2570 NNVDQQQQQQMRRRTMSMCITPVTPTPVVTPSPLHGTPPSTKKRQTNFEQELTKPNSQILSSSIL 2634

Mouse  2029 ---------PVKPPPRPLLELPS--HPPQHRKDRWDEAGPATALPSSAGPGQGHEADGQWATSEF 2082
                     |:..|  .::.:|:  ...||||    |.....|.|:|.||        ....:..
  Fly  2635 LNSSKGLGLPLAAP--TVVSVPTAVQQQQHRK----ENNHQEATPASGGP--------MSLAAAI 2685

Mouse  2083 REGKGHEYRSPAFEGRQRERFEAGSKEKPLDEPEAQGLESRQGRAFEDRRRERERGRNWSRERDW 2147
            ..||.:..      .|:||.. .||:::          ::....|.:..::|:::    |:::|.
  Fly  2686 ASGKLNAI------SRRRESM-CGSRQQ----------QALIAAALKKEKKEKKK----SKKKDR 2729

Mouse  2148 ERSRDWDRHREWDKGRDRSSNRDRERDN 2175
            |:.:     .:..||:::...:|:|:||
  Fly  2730 EKQK-----HDKQKGKEKEREKDKEKDN 2752

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dido1NP_780760.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..256 38/204 (19%)
TNG2 <157..299 CDD:227367 42/176 (24%)
Nuclear localization signal. /evidence=ECO:0000255 162..170 2/7 (29%)
Nuclear localization signal. /evidence=ECO:0000255 182..190 1/7 (14%)
PHD_DIDO1_like 263..316 CDD:277109 19/52 (37%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 481..535 8/58 (14%)
PHA03247 <483..663 CDD:223021 38/206 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 598..624 7/26 (27%)
PRK14954 <600..>665 CDD:184918 16/65 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 641..668 4/26 (15%)
TFS2M 669..770 CDD:128786 17/100 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 778..822 6/45 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 856..970 19/114 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1011..1039 11/36 (31%)
SPOC 1045..1190 CDD:369497 27/189 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1197..1218 4/28 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1245..1288 9/52 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1320..1347 7/30 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1362..1421 14/66 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1509..1609 20/108 (19%)
PHA03247 <1571..2083 CDD:223021 105/630 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1630..2256 110/665 (17%)
SF-CC1 2142..>2180 CDD:273721 9/34 (26%)
upSETNP_001261819.1 PHD_MLL5 856..899 CDD:277025 19/48 (40%)
SET <1221..1273 CDD:214614 13/95 (14%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4489
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.030

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