DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cdh20 and CadN

DIOPT Version :9

Sequence 1:	NP_035930.1	Gene:	Cdh20 / 23836	MGIID:	1346069	Length:	801	Species:	Mus musculus
Sequence 2:	NP_001027277.1	Gene:	CadN / 35070	FlyBaseID:	FBgn0015609	Length:	3101	Species:	Drosophila melanogaster

Alignment Length:	573	Identity:	183/573 - (31%)
Similarity:	282/573 - (49%)	Gaps:	73/573 - (12%)

- Green bases have known domain annotations that are detailed below.

Mouse    71 EYTGTDPLYVGKLHSDMDRGDGSIKYILSGEG------AGIVFTIDDTTGDIHAIQRLDREE--- 126
            :.|.||        .|.||.. :|.|.|:|:|      |...|.|:.|||:|..::.|||::
  Fly  1541 QVTATD--------GDKDRPQ-NIVYFLTGQGIDPDNPANSKFDINRTTGEIFVLKPLDRDQPNG 1596

Mouse   127 RAQYTLRAQALDRRTGRPMEPESEFIIKIQDINDNEPKFLDGPYIATVPEMSPVGTSVIQVTATD 191
            |.|:.....|.| ..|..:...::..:.::|||||.|.|..|.|...|.|....|..|:.:||.|
  Fly  1597 RPQWRFTVFAQD-EGGEGLVGYADVQVNLKDINDNAPIFPQGVYFGNVTENGTAGMVVMTMTAVD 1660

Mouse   192 ADDPTYGNSARVVYSILQ-------GQPYFSVDSKTGVIRTALMNMDREAKEYYEVIIQAKDMGG 249
            .|||..|::||:||||.:       |.|.|.::..||||:||:..:|||....|.:.:.|.|.
  Fly  1661 YDDPNEGSNARLVYSIEKNVIEEETGSPIFEIEPDTGVIKTAVCCLDRERTPDYSIQVVAMDG-- 1723

Mouse   250 QLGGLAGTTTVNITLSDVNDNPPRFPQKHYQMSV-------LESAPISSTVGRVFAKDLDEGINA 307
              |||.||.|.:|.:.|:||.||:|.:..:...|       |...||.:    |...|.||  ..
  Fly  1724 --GGLKGTGTASIRVKDINDMPPQFTKDEWFTEVDETDGTALPEMPILT----VTVHDEDE--TN 1780

Mouse   308 EMKYTIVD--GDGADAFDINTDQNFQVGIITVKKPLSFESKKSYTLKVEGSNPHLEMRFLNLGPF 370
            :.:|.::|  |.|||.|.: ...|...|.:.:.:||.:|.:    |:..|....:::.  :.|..
  Fly  1781 KFQYKVIDNSGYGADKFTM-VRNNDGTGSLKIVQPLDYEDQ----LQSNGFRFRIQVN--DKGED 1838

Mouse   371 QDTTTVHIS-------VEDV-DEPPVFEPGFYFVEVPEDVTIGTTIQIISAKDPDVTNNS-IRYS 426
            .|....|::       :.|: |..|.||.....|.|.||..:||.::...|.|||....| :.||
  Fly  1839 NDNDKYHVAYSWVVVKLRDINDNKPHFERANVEVSVFEDTKVGTELEKFKATDPDQGGKSKVSYS 1903

Mouse   427 IDRGSDPGRFFYVDITTGALMTARPLDREEFSWHNITVLAMEMNNPSQVGSVAVTIKVLDVNDNA 491
            |||.||..|.|.:: ..|::...|.||||....|.:.:||::..:|.:..:..:|:.|.|:||||
  Fly  1904 IDRSSDRQRQFAIN-QNGSVTIQRSLDREVVPRHQVKILAIDDGSPPKTATATLTVIVQDINDNA 1967

Mouse   492 PEFPRFYEAFICENAKAGQLIQTVSAVDQDD--PHNGQHFYYSLAPEAAN--NPNFTVRDNQ--- 549
            |:|.:.|...:.|:....:::: :.|.|.||  ..||..|.:.|.|.|.:  ..:|.|..:|
  Fly  1968 PKFLKDYRPVLPEHVPPRKVVE-ILATDDDDRSKSNGPPFQFRLDPSADDIIRASFKVEQDQKGA 2031

Mouse   550 --DNTARILTRRSGFRQQEQSVFYLPILIADSGQPVLSSTGTLTIQVCSCNDD 600
              |..|.|.:.|| |.:::|..:.:||:|.|.|.|.::.|.|||:.:...||:
  Fly  2032 NGDGMAVISSLRS-FDREQQKEYMIPIVIKDHGSPAMTGTSTLTVIIGDVNDN 2083

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cdh20	NP_035930.1	CA	85..163	CDD:214520	28/86 (33%)
		Cadherin_repeat	169..270	CDD:206637	42/107 (39%)
		Cadherin_repeat	278..385	CDD:206637	26/123 (21%)
		Cadherin_repeat	394..490	CDD:206637	34/96 (35%)
		Cadherin_repeat	498..599	CDD:206637	32/109 (29%)
		Cadherin_C	643..794	CDD:366437
CadN	NP_001027277.1	Cadherin_repeat	178..301	CDD:206637
		Cadherin_repeat	337..396	CDD:206637
		E_set	449..541	CDD:298831
		Cadherin_repeat	549..>625	CDD:206637
		Cadherin_repeat	655..752	CDD:206637
		Cadherin_repeat	765..853	CDD:206637
		Cadherin_repeat	862..964	CDD:206637
		Cadherin_repeat	973..1074	CDD:206637
		Cadherin_repeat	1083..1166	CDD:206637
		Cadherin_repeat	<1219..1298	CDD:206637
		Cadherin_repeat	1310..1414	CDD:206637
		Cadherin_repeat	1423..1514	CDD:206637
		Cadherin_repeat	1522..1630	CDD:206637	29/98 (30%)
		Cadherin_repeat	1638..1741	CDD:206637	41/106 (39%)
		Cadherin_repeat	1762..1861	CDD:206637	25/111 (23%)
		Cadherin_repeat	1871..1966	CDD:206637	34/95 (36%)
		Cadherin_repeat	1974..2083	CDD:206637	33/110 (30%)
		EGF	2350..2380	CDD:278437
		LamG	2385..2570	CDD:238058
		EGF_2	<2605..2631	CDD:285248
		Laminin_G_2	2665..2800	CDD:280389
		EGF_CA	2869..2907	CDD:238011
		Cadherin_C	2952..3088	CDD:279398
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	130	1.000	Domainoid score	I5176
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910